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@ARTICLE{Haussmann:139122,
      author       = {Haussmann, Robert and Werner, Annett and Gruschwitz,
                      Antonia and Osterrath, Antje and Lange, Jan and Donix,
                      Katharina L and Linn, Jennifer and Donix, Markus},
      title        = {{P}recuneus {S}tructure {C}hanges in {A}mnestic {M}ild
                      {C}ognitive {I}mpairment.},
      journal      = {American journal of Alzheimer's disease and other
                      dementias},
      volume       = {32},
      number       = {1},
      issn         = {1533-3175},
      address      = {Thousand Oaks, Calif.},
      publisher    = {Sage},
      reportid     = {DZNE-2020-05444},
      pages        = {22-26},
      year         = {2017},
      abstract     = {Patients with amnestic mild cognitive impairment (aMCI) are
                      at risk for developing Alzheimer's disease. Due to their
                      prominent memory impairment, structural magnetic resonance
                      imaging (MRI) often focuses on the hippocampal region.
                      However, recent positron-emission tomography data suggest
                      that within a network of frontal and temporal changes,
                      patients with aMCI show metabolic alterations in the
                      precuneus, a key region for higher cognitive functions.
                      Using high-resolution MRI and whole-brain cortical thickness
                      analyses in 28 patients with aMCI and 25 healthy
                      individuals, we wanted to investigate whether structural
                      changes in the precuneus would be associated with cortical
                      thickness reductions in frontal and temporal brain regions
                      in patients with aMCI. In contrast to healthy people,
                      patients with aMCI showed an association of cortical
                      thinning in the precuneus with predominantly
                      left-hemispheric thickness reductions in medial temporal and
                      frontal cortices. Our data highlight structural neuronal
                      network characteristics among patients with aMCI.},
      keywords     = {Aged / Aged, 80 and over / Amnesia: pathology / Cerebral
                      Cortex: pathology / Cognitive Dysfunction: pathology /
                      Female / Humans / Magnetic Resonance Imaging: methods / Male
                      / Middle Aged / Parietal Lobe: pathology},
      cin          = {Pre 2020 / AG Garthe / AG Falkenburger},
      ddc          = {610},
      cid          = {I:(DE-2719)999999 / I:(DE-2719)1740001 /
                      I:(DE-2719)1710012},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 344
                      - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28100076},
      doi          = {10.1177/1533317516678087},
      url          = {https://pub.dzne.de/record/139122},
}