001     139122
005     20240722104745.0
024 7 _ |a 0888-4897
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024 7 _ |a 10.1177/1533317516678087
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024 7 _ |a pmid:28100076
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024 7 _ |a 0895-5336
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024 7 _ |a 1082-5207
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024 7 _ |a 1533-3175
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024 7 _ |a 1938-2731
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037 _ _ |a DZNE-2020-05444
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Haussmann, Robert
|0 P:(DE-HGF)0
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245 _ _ |a Precuneus Structure Changes in Amnestic Mild Cognitive Impairment.
260 _ _ |a Thousand Oaks, Calif.
|c 2017
|b Sage
264 _ 1 |3 online
|2 Crossref
|b SAGE Publications
|c 2016-11-15
264 _ 1 |3 print
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|b SAGE Publications
|c 2017-02-01
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Patients with amnestic mild cognitive impairment (aMCI) are at risk for developing Alzheimer's disease. Due to their prominent memory impairment, structural magnetic resonance imaging (MRI) often focuses on the hippocampal region. However, recent positron-emission tomography data suggest that within a network of frontal and temporal changes, patients with aMCI show metabolic alterations in the precuneus, a key region for higher cognitive functions. Using high-resolution MRI and whole-brain cortical thickness analyses in 28 patients with aMCI and 25 healthy individuals, we wanted to investigate whether structural changes in the precuneus would be associated with cortical thickness reductions in frontal and temporal brain regions in patients with aMCI. In contrast to healthy people, patients with aMCI showed an association of cortical thinning in the precuneus with predominantly left-hemispheric thickness reductions in medial temporal and frontal cortices. Our data highlight structural neuronal network characteristics among patients with aMCI.
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542 _ _ |i 2016-11-15
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588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Aged
|2 MeSH
650 _ 2 |a Aged, 80 and over
|2 MeSH
650 _ 2 |a Amnesia: pathology
|2 MeSH
650 _ 2 |a Cerebral Cortex: pathology
|2 MeSH
650 _ 2 |a Cognitive Dysfunction: pathology
|2 MeSH
650 _ 2 |a Female
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Magnetic Resonance Imaging: methods
|2 MeSH
650 _ 2 |a Male
|2 MeSH
650 _ 2 |a Middle Aged
|2 MeSH
650 _ 2 |a Parietal Lobe: pathology
|2 MeSH
700 1 _ |a Werner, Annett
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700 1 _ |a Gruschwitz, Antonia
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700 1 _ |a Osterrath, Antje
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700 1 _ |a Lange, Jan
|b 4
700 1 _ |a Donix, Katharina L
|b 5
700 1 _ |a Linn, Jennifer
|b 6
700 1 _ |a Donix, Markus
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773 1 8 |a 10.1177/1533317516678087
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|t American Journal of Alzheimer's Disease & Other Dementiasr
|v 32
|y 2016
|x 1533-3175
773 _ _ |a 10.1177/1533317516678087
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|t American journal of Alzheimer's disease and other dementias
|v 32
|y 2017
|x 1533-3175
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LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21