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000139389 1001_ $$0P:(DE-2719)2811120$$aDittrich, Lars$$b0$$eFirst author$$udzne
000139389 245__ $$aThe natural Disc1-deletion present in several inbred mouse strains does not affect sleep.
000139389 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2017
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000139389 520__ $$aThe gene Disrupted in Schizophrenia-1 (DISC1) is linked to a range of psychiatric disorders. Two recent transgenic studies suggest DISC1 is also involved in homeostatic sleep regulation. Several strains of inbred mice commonly used for genome manipulation experiments, including several Swiss and likely all 129 substrains, carry a natural deletion mutation of Disc1. This constitutes a potential confound for studying sleep in genetically modified mice. Since disturbed sleep can also influence psychiatric and neurodegenerative disease models, this putative confound might affect a wide range of studies in several fields. Therefore, we asked to what extent the natural Disc1 deletion affects sleep. To this end, we first compared sleep and electroencephalogram (EEG) phenotypes of 129S4 mice carrying the Disc1 deletion and C57BL/6N mice carrying the full-length version. We then bred Disc1 from C57BL/6N into the 129S4 background, resulting in S4-Disc1 mice. The differences between 129S4 and C57BL/6N were not detected in the 129S4 to S4-Disc1 comparison. We conclude that the mutation has no effect on the measured sleep and EEG characteristics. Thus, it is unlikely the widespread Disc1 deletion has led to spurious results in previous sleep studies or that it alters sleep in mouse models of psychiatric or neurodegenerative diseases.
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000139389 650_7 $$2NLM Chemicals$$aDisc1 protein, mouse
000139389 650_7 $$2NLM Chemicals$$aNerve Tissue Proteins
000139389 650_2 $$2MeSH$$aAnimals
000139389 650_2 $$2MeSH$$aBreeding
000139389 650_2 $$2MeSH$$aElectroencephalography
000139389 650_2 $$2MeSH$$aFemale
000139389 650_2 $$2MeSH$$aMale
000139389 650_2 $$2MeSH$$aMice
000139389 650_2 $$2MeSH$$aMice, Inbred C57BL
000139389 650_2 $$2MeSH$$aMice, Inbred Strains
000139389 650_2 $$2MeSH$$aNerve Tissue Proteins: genetics
000139389 650_2 $$2MeSH$$aSequence Deletion
000139389 650_2 $$2MeSH$$aSleep: genetics
000139389 650_2 $$2MeSH$$aSleep: physiology
000139389 7001_ $$0P:(DE-2719)2811366$$aPetese, Alessandro$$b1$$udzne
000139389 7001_ $$0P:(DE-2719)2810253$$aJackson, Walker S$$b2$$eLast author$$udzne
000139389 77318 $$2Crossref$$3journal-article$$a10.1038/s41598-017-06015-3$$b : Springer Science and Business Media LLC, 2017-07-18$$n1$$p5665$$tScientific Reports$$v7$$x2045-2322$$y2017
000139389 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-017-06015-3$$gVol. 7, no. 1, p. 5665$$n1$$p5665$$q7:1<5665$$tScientific reports$$v7$$x2045-2322$$y2017
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