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@ARTICLE{Dittrich:139389,
      author       = {Dittrich, Lars and Petese, Alessandro and Jackson, Walker
                      S},
      title        = {{T}he natural {D}isc1-deletion present in several inbred
                      mouse strains does not affect sleep.},
      journal      = {Scientific reports},
      volume       = {7},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {DZNE-2020-05711},
      pages        = {5665},
      year         = {2017},
      abstract     = {The gene Disrupted in Schizophrenia-1 (DISC1) is linked to
                      a range of psychiatric disorders. Two recent transgenic
                      studies suggest DISC1 is also involved in homeostatic sleep
                      regulation. Several strains of inbred mice commonly used for
                      genome manipulation experiments, including several Swiss and
                      likely all 129 substrains, carry a natural deletion mutation
                      of Disc1. This constitutes a potential confound for studying
                      sleep in genetically modified mice. Since disturbed sleep
                      can also influence psychiatric and neurodegenerative disease
                      models, this putative confound might affect a wide range of
                      studies in several fields. Therefore, we asked to what
                      extent the natural Disc1 deletion affects sleep. To this
                      end, we first compared sleep and electroencephalogram (EEG)
                      phenotypes of 129S4 mice carrying the Disc1 deletion and
                      C57BL/6N mice carrying the full-length version. We then bred
                      Disc1 from C57BL/6N into the 129S4 background, resulting in
                      S4-Disc1 mice. The differences between 129S4 and C57BL/6N
                      were not detected in the 129S4 to S4-Disc1 comparison. We
                      conclude that the mutation has no effect on the measured
                      sleep and EEG characteristics. Thus, it is unlikely the
                      widespread Disc1 deletion has led to spurious results in
                      previous sleep studies or that it alters sleep in mouse
                      models of psychiatric or neurodegenerative diseases.},
      keywords     = {Animals / Breeding / Electroencephalography / Female / Male
                      / Mice / Mice, Inbred C57BL / Mice, Inbred Strains / Nerve
                      Tissue Proteins: genetics / Sequence Deletion / Sleep:
                      genetics / Sleep: physiology / Disc1 protein, mouse (NLM
                      Chemicals) / Nerve Tissue Proteins (NLM Chemicals)},
      cin          = {Pre 2020},
      ddc          = {600},
      cid          = {I:(DE-2719)999999},
      pnm          = {899H - Addenda (POF3-899H)},
      pid          = {G:(DE-HGF)POF3-899H},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28720848},
      pmc          = {pmc:PMC5515846},
      doi          = {10.1038/s41598-017-06015-3},
      url          = {https://pub.dzne.de/record/139389},
}