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| Home > Publications Database > The natural Disc1-deletion present in several inbred mouse strains does not affect sleep. > print |
| 001 | 139389 | ||
| 005 | 20240514120212.0 | ||
| 024 | 7 | _ | |a 10.1038/s41598-017-06015-3 |2 doi |
| 024 | 7 | _ | |a pmid:28720848 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5515846 |2 pmc |
| 024 | 7 | _ | |a altmetric:22185497 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05711 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 600 |
| 100 | 1 | _ | |a Dittrich, Lars |0 P:(DE-2719)2811120 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a The natural Disc1-deletion present in several inbred mouse strains does not affect sleep. |
| 260 | _ | _ | |a [London] |c 2017 |b Macmillan Publishers Limited, part of Springer Nature |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2017-07-18 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2017-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1715604081_2123 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The gene Disrupted in Schizophrenia-1 (DISC1) is linked to a range of psychiatric disorders. Two recent transgenic studies suggest DISC1 is also involved in homeostatic sleep regulation. Several strains of inbred mice commonly used for genome manipulation experiments, including several Swiss and likely all 129 substrains, carry a natural deletion mutation of Disc1. This constitutes a potential confound for studying sleep in genetically modified mice. Since disturbed sleep can also influence psychiatric and neurodegenerative disease models, this putative confound might affect a wide range of studies in several fields. Therefore, we asked to what extent the natural Disc1 deletion affects sleep. To this end, we first compared sleep and electroencephalogram (EEG) phenotypes of 129S4 mice carrying the Disc1 deletion and C57BL/6N mice carrying the full-length version. We then bred Disc1 from C57BL/6N into the 129S4 background, resulting in S4-Disc1 mice. The differences between 129S4 and C57BL/6N were not detected in the 129S4 to S4-Disc1 comparison. We conclude that the mutation has no effect on the measured sleep and EEG characteristics. Thus, it is unlikely the widespread Disc1 deletion has led to spurious results in previous sleep studies or that it alters sleep in mouse models of psychiatric or neurodegenerative diseases. |
| 536 | _ | _ | |a 899H - Addenda (POF3-899H) |0 G:(DE-HGF)POF3-899H |c POF3-899H |f POF III |x 0 |
| 542 | _ | _ | |i 2017-07-18 |2 Crossref |u http://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Disc1 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Nerve Tissue Proteins |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Breeding |2 MeSH |
| 650 | _ | 2 | |a Electroencephalography |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred Strains |2 MeSH |
| 650 | _ | 2 | |a Nerve Tissue Proteins: genetics |2 MeSH |
| 650 | _ | 2 | |a Sequence Deletion |2 MeSH |
| 650 | _ | 2 | |a Sleep: genetics |2 MeSH |
| 650 | _ | 2 | |a Sleep: physiology |2 MeSH |
| 700 | 1 | _ | |a Petese, Alessandro |0 P:(DE-2719)2811366 |b 1 |u dzne |
| 700 | 1 | _ | |a Jackson, Walker S |0 P:(DE-2719)2810253 |b 2 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1038/s41598-017-06015-3 |b : Springer Science and Business Media LLC, 2017-07-18 |n 1 |p 5665 |3 journal-article |2 Crossref |t Scientific Reports |v 7 |y 2017 |x 2045-2322 |
| 773 | _ | _ | |a 10.1038/s41598-017-06015-3 |g Vol. 7, no. 1, p. 5665 |0 PERI:(DE-600)2615211-3 |n 1 |q 7:1<5665 |p 5665 |t Scientific reports |v 7 |y 2017 |x 2045-2322 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/139389/files/DZNE-2020-05711.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/139389/files/DZNE-2020-05711.pdf?subformat=pdfa |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5515846 |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2811120 |
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| 914 | 1 | _ | |y 2017 |
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