%0 Journal Article
%A Srulijes, Karin
%A Brockmann, Kathrin
%A Ogbamicael, Senait
%A Hobert, Markus A
%A Hauser, Ann-Kathrin
%A Schulte, Claudia
%A Fritzen, Jasmin
%A Schwenk, Michael
%A Gasser, Thomas
%A Berg, Daniela
%A Maetzler, Walter
%T Dual-Task Performance in GBA Parkinson's Disease.
%J Parkinson's disease
%V 2017
%@ 2090-8083
%C London [u.a.]
%I Hindawi
%M DZNE-2020-05760
%P 8582740
%D 2017
%X Parkinson's disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients.Eleven GBA-PD patients (p.N370S, p.L444P) and eleven matched iPD patients were included. Clinical characterization included a motor score (Unified PD Rating Scale-III, UPDRS-III) and nonmotor scores (Montreal Cognitive Assessment, MoCA, and Beck's Depression Inventory). Quantitative gait analysis during the single-task (ST) and DT assessments was performed using a wearable sensor unit. These parameters corrected for UPDRS and MoCA were then compared between the groups.Under the DT condition 'walking while checking boxes,' GBA-PD patients showed slower gait and box-checking speeds than iPD patients. GBA-PD and iPD patients did not show significant differences regarding dual-task costs.This pilot study suggests that DT performance with a secondary motor task is worse in GBA-PD than in iPD patients. This finding may be associated with the known enhanced motor and cognitive deficits in GBA-PD compared to iPD and should motivate further studies.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:28819579
%2 pmc:PMC5551514
%R 10.1155/2017/8582740
%U https://pub.dzne.de/record/139438