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000139438 1001_ $$0P:(DE-2719)9000298$$aSrulijes, Karin$$b0$$eFirst author$$udzne
000139438 245__ $$aDual-Task Performance in GBA Parkinson's Disease.
000139438 260__ $$aLondon [u.a.]$$bHindawi$$c2017
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000139438 520__ $$aParkinson's disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients.Eleven GBA-PD patients (p.N370S, p.L444P) and eleven matched iPD patients were included. Clinical characterization included a motor score (Unified PD Rating Scale-III, UPDRS-III) and nonmotor scores (Montreal Cognitive Assessment, MoCA, and Beck's Depression Inventory). Quantitative gait analysis during the single-task (ST) and DT assessments was performed using a wearable sensor unit. These parameters corrected for UPDRS and MoCA were then compared between the groups.Under the DT condition 'walking while checking boxes,' GBA-PD patients showed slower gait and box-checking speeds than iPD patients. GBA-PD and iPD patients did not show significant differences regarding dual-task costs.This pilot study suggests that DT performance with a secondary motor task is worse in GBA-PD than in iPD patients. This finding may be associated with the known enhanced motor and cognitive deficits in GBA-PD compared to iPD and should motivate further studies.
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000139438 7001_ $$0P:(DE-2719)2811916$$aBrockmann, Kathrin$$b1$$udzne
000139438 7001_ $$0P:(DE-2719)9000238$$aOgbamicael, Senait$$b2$$udzne
000139438 7001_ $$0P:(DE-2719)9000133$$aHobert, Markus A$$b3$$udzne
000139438 7001_ $$0P:(DE-2719)2351249$$aHauser, Ann-Kathrin$$b4$$udzne
000139438 7001_ $$0P:(DE-2719)9000366$$aSchulte, Claudia$$b5$$udzne
000139438 7001_ $$0P:(DE-2719)9000084$$aFritzen, Jasmin$$b6$$udzne
000139438 7001_ $$0P:(DE-HGF)0$$aSchwenk, Michael$$b7
000139438 7001_ $$0P:(DE-2719)2320009$$aGasser, Thomas$$b8$$udzne
000139438 7001_ $$0P:(DE-2719)2000059$$aBerg, Daniela$$b9$$udzne
000139438 7001_ $$0P:(DE-2719)2810915$$aMaetzler, Walter$$b10$$eLast author$$udzne
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