TY  - JOUR
AU  - Srulijes, Karin
AU  - Brockmann, Kathrin
AU  - Ogbamicael, Senait
AU  - Hobert, Markus A
AU  - Hauser, Ann-Kathrin
AU  - Schulte, Claudia
AU  - Fritzen, Jasmin
AU  - Schwenk, Michael
AU  - Gasser, Thomas
AU  - Berg, Daniela
AU  - Maetzler, Walter
TI  - Dual-Task Performance in GBA Parkinson's Disease.
JO  - Parkinson's disease
VL  - 2017
SN  - 2090-8083
CY  - London [u.a.]
PB  - Hindawi
M1  - DZNE-2020-05760
SP  - 8582740
PY  - 2017
AB  - Parkinson's disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients.Eleven GBA-PD patients (p.N370S, p.L444P) and eleven matched iPD patients were included. Clinical characterization included a motor score (Unified PD Rating Scale-III, UPDRS-III) and nonmotor scores (Montreal Cognitive Assessment, MoCA, and Beck's Depression Inventory). Quantitative gait analysis during the single-task (ST) and DT assessments was performed using a wearable sensor unit. These parameters corrected for UPDRS and MoCA were then compared between the groups.Under the DT condition 'walking while checking boxes,' GBA-PD patients showed slower gait and box-checking speeds than iPD patients. GBA-PD and iPD patients did not show significant differences regarding dual-task costs.This pilot study suggests that DT performance with a secondary motor task is worse in GBA-PD than in iPD patients. This finding may be associated with the known enhanced motor and cognitive deficits in GBA-PD compared to iPD and should motivate further studies.
LB  - PUB:(DE-HGF)16
C6  - pmid:28819579
C2  - pmc:PMC5551514
DO  - DOI:10.1155/2017/8582740
UR  - https://pub.dzne.de/record/139438
ER  -