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@ARTICLE{Srulijes:139438,
      author       = {Srulijes, Karin and Brockmann, Kathrin and Ogbamicael,
                      Senait and Hobert, Markus A and Hauser, Ann-Kathrin and
                      Schulte, Claudia and Fritzen, Jasmin and Schwenk, Michael
                      and Gasser, Thomas and Berg, Daniela and Maetzler, Walter},
      title        = {{D}ual-{T}ask {P}erformance in {GBA} {P}arkinson's
                      {D}isease.},
      journal      = {Parkinson's disease},
      volume       = {2017},
      issn         = {2090-8083},
      address      = {London [u.a.]},
      publisher    = {Hindawi},
      reportid     = {DZNE-2020-05760},
      pages        = {8582740},
      year         = {2017},
      abstract     = {Parkinson's disease patients carrying a heterozygous
                      mutation in the gene glucocerebrosidase (GBA-PD) show faster
                      motor and cognitive decline than idiopathic Parkinson's
                      disease (iPD) patients, but the mechanisms behind this
                      observation are not well understood. Successful dual tasking
                      (DT) requires a smooth integration of motor and nonmotor
                      operations. This study compared the DT performances between
                      GBA-PD and iPD patients.Eleven GBA-PD patients (p.N370S,
                      p.L444P) and eleven matched iPD patients were included.
                      Clinical characterization included a motor score (Unified PD
                      Rating Scale-III, UPDRS-III) and nonmotor scores (Montreal
                      Cognitive Assessment, MoCA, and Beck's Depression
                      Inventory). Quantitative gait analysis during the
                      single-task (ST) and DT assessments was performed using a
                      wearable sensor unit. These parameters corrected for UPDRS
                      and MoCA were then compared between the groups.Under the DT
                      condition 'walking while checking boxes,' GBA-PD patients
                      showed slower gait and box-checking speeds than iPD
                      patients. GBA-PD and iPD patients did not show significant
                      differences regarding dual-task costs.This pilot study
                      suggests that DT performance with a secondary motor task is
                      worse in GBA-PD than in iPD patients. This finding may be
                      associated with the known enhanced motor and cognitive
                      deficits in GBA-PD compared to iPD and should motivate
                      further studies.},
      cin          = {AG Berg ; AG Berg / AG Gasser / AG Maetzler / Ext UKT},
      ddc          = {610},
      cid          = {I:(DE-2719)5000055 / I:(DE-2719)1210000 /
                      I:(DE-2719)5000024 / I:(DE-2719)5000058},
      pnm          = {345 - Population Studies and Genetics (POF3-345) / 344 -
                      Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-345 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28819579},
      pmc          = {pmc:PMC5551514},
      doi          = {10.1155/2017/8582740},
      url          = {https://pub.dzne.de/record/139438},
}