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| 001 | 139438 | ||
| 005 | 20240511120145.0 | ||
| 024 | 7 | _ | |a 10.1155/2017/8582740 |2 doi |
| 024 | 7 | _ | |a pmid:28819579 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5551514 |2 pmc |
| 024 | 7 | _ | |a 2042-0080 |2 ISSN |
| 024 | 7 | _ | |a 2090-8083 |2 ISSN |
| 024 | 7 | _ | |a altmetric:24075126 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05760 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Srulijes, Karin |0 P:(DE-2719)9000298 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Dual-Task Performance in GBA Parkinson's Disease. |
| 260 | _ | _ | |a London [u.a.] |c 2017 |b Hindawi |
| 264 | _ | 1 | |3 print |2 Crossref |b Hindawi Limited |c 2017-01-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1715351703_4832 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Parkinson's disease patients carrying a heterozygous mutation in the gene glucocerebrosidase (GBA-PD) show faster motor and cognitive decline than idiopathic Parkinson's disease (iPD) patients, but the mechanisms behind this observation are not well understood. Successful dual tasking (DT) requires a smooth integration of motor and nonmotor operations. This study compared the DT performances between GBA-PD and iPD patients.Eleven GBA-PD patients (p.N370S, p.L444P) and eleven matched iPD patients were included. Clinical characterization included a motor score (Unified PD Rating Scale-III, UPDRS-III) and nonmotor scores (Montreal Cognitive Assessment, MoCA, and Beck's Depression Inventory). Quantitative gait analysis during the single-task (ST) and DT assessments was performed using a wearable sensor unit. These parameters corrected for UPDRS and MoCA were then compared between the groups.Under the DT condition 'walking while checking boxes,' GBA-PD patients showed slower gait and box-checking speeds than iPD patients. GBA-PD and iPD patients did not show significant differences regarding dual-task costs.This pilot study suggests that DT performance with a secondary motor task is worse in GBA-PD than in iPD patients. This finding may be associated with the known enhanced motor and cognitive deficits in GBA-PD compared to iPD and should motivate further studies. |
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| 542 | _ | _ | |i 2017-01-01 |2 Crossref |u http://creativecommons.org/licenses/by/4.0/ |
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| 700 | 1 | _ | |a Brockmann, Kathrin |0 P:(DE-2719)2811916 |b 1 |u dzne |
| 700 | 1 | _ | |a Ogbamicael, Senait |0 P:(DE-2719)9000238 |b 2 |u dzne |
| 700 | 1 | _ | |a Hobert, Markus A |0 P:(DE-2719)9000133 |b 3 |u dzne |
| 700 | 1 | _ | |a Hauser, Ann-Kathrin |0 P:(DE-2719)2351249 |b 4 |u dzne |
| 700 | 1 | _ | |a Schulte, Claudia |0 P:(DE-2719)9000366 |b 5 |u dzne |
| 700 | 1 | _ | |a Fritzen, Jasmin |0 P:(DE-2719)9000084 |b 6 |u dzne |
| 700 | 1 | _ | |a Schwenk, Michael |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Gasser, Thomas |0 P:(DE-2719)2320009 |b 8 |u dzne |
| 700 | 1 | _ | |a Berg, Daniela |0 P:(DE-2719)2000059 |b 9 |u dzne |
| 700 | 1 | _ | |a Maetzler, Walter |0 P:(DE-2719)2810915 |b 10 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1155/2017/8582740 |b : Hindawi Limited, 2017-01-01 |p 1-6 |3 journal-article |2 Crossref |t Parkinson's Disease |v 2017 |y 2017 |x 2090-8083 |
| 773 | _ | _ | |a 10.1155/2017/8582740 |g Vol. 2017, p. 1 - 6 |0 PERI:(DE-600)2573854-9 |q 2017<1 - 6 |p 8582740 |t Parkinson's disease |v 2017 |y 2017 |x 2090-8083 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/139438/files/DZNE-2020-05760.pdf |
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| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5551514 |
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| 914 | 1 | _ | |y 2017 |
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