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000139476 037__ $$aDZNE-2020-05798
000139476 041__ $$aEnglish
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000139476 1001_ $$aLester, Adam W$$b0
000139476 245__ $$aThe Aging Navigational System.
000139476 260__ $$aNew York, NY$$bElsevier$$c2017
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000139476 520__ $$aThe discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.
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000139476 650_2 $$2MeSH$$aAging: physiology
000139476 650_2 $$2MeSH$$aAnimals
000139476 650_2 $$2MeSH$$aHumans
000139476 650_2 $$2MeSH$$aLearning: physiology
000139476 650_2 $$2MeSH$$aNeurodegenerative Diseases: physiopathology
000139476 650_2 $$2MeSH$$aSpatial Memory: physiology
000139476 650_2 $$2MeSH$$aSpatial Navigation: physiology
000139476 650_2 $$2MeSH$$aSpatial Processing: physiology
000139476 7001_ $$aMoffat, Scott D$$b1
000139476 7001_ $$aWiener, Jan M$$b2
000139476 7001_ $$aBarnes, Carol A$$b3
000139476 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b4$$eLast author$$udzne
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000139476 773__ $$0PERI:(DE-600)2001944-0$$a10.1016/j.neuron.2017.06.037$$gVol. 95, no. 5, p. 1019 - 1035$$n5$$p1019-1035$$q95:5<1019 - 1035$$tNeuron$$v95$$x0896-6273$$y2017
000139476 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659315
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