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@ARTICLE{Lester:139476,
      author       = {Lester, Adam W and Moffat, Scott D and Wiener, Jan M and
                      Barnes, Carol A and Wolbers, Thomas},
      title        = {{T}he {A}ging {N}avigational {S}ystem.},
      journal      = {Neuron},
      volume       = {95},
      number       = {5},
      issn         = {0896-6273},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-05798},
      pages        = {1019-1035},
      year         = {2017},
      abstract     = {The discovery of neuronal systems dedicated to computing
                      spatial information, composed of functionally distinct cell
                      types such as place and grid cells, combined with an
                      extensive body of human-based behavioral and neuroimaging
                      research has provided us with a detailed understanding of
                      the brain's navigation circuit. In this review, we discuss
                      emerging evidence from rodents, non-human primates, and
                      humans that demonstrates how cognitive aging affects the
                      navigational computations supported by these systems.
                      Critically, we show 1) that navigational deficits cannot
                      solely be explained by general deficits in learning and
                      memory, 2) that there is no uniform decline across
                      different navigational computations, and 3) that
                      navigational deficits might be sensitive markers for
                      impending pathological decline. Following an introduction to
                      the mechanisms underlying spatial navigation and how they
                      relate to general processes of learning and memory, the
                      review discusses how aging affects the perception and
                      integration of spatial information, the creation and storage
                      of memory traces for spatial information, and the use of
                      spatial information during navigational behavior. The
                      closing section highlights the clinical potential of
                      behavioral and neural markers of spatial navigation, with a
                      particular emphasis on neurodegenerative disorders.},
      subtyp        = {Review Article},
      keywords     = {Aging: physiology / Animals / Humans / Learning: physiology
                      / Neurodegenerative Diseases: physiopathology / Spatial
                      Memory: physiology / Spatial Navigation: physiology /
                      Spatial Processing: physiology},
      cin          = {AG Wolbers},
      ddc          = {610},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28858613},
      pmc          = {pmc:PMC5659315},
      doi          = {10.1016/j.neuron.2017.06.037},
      url          = {https://pub.dzne.de/record/139476},
}