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001     139476
005     20240321220627.0
024 7 _ |a 10.1016/j.neuron.2017.06.037
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024 7 _ |a pmid:28858613
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024 7 _ |a pmc:PMC5659315
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024 7 _ |a 0896-6273
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024 7 _ |a 1097-4199
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024 7 _ |a altmetric:24533895
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037 _ _ |a DZNE-2020-05798
041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Lester, Adam W
|b 0
245 _ _ |a The Aging Navigational System.
260 _ _ |a New York, NY
|c 2017
|b Elsevier
264 _ 1 |3 print
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|b Elsevier BV
|c 2017-08-01
336 7 _ |a article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a The discovery of neuronal systems dedicated to computing spatial information, composed of functionally distinct cell types such as place and grid cells, combined with an extensive body of human-based behavioral and neuroimaging research has provided us with a detailed understanding of the brain's navigation circuit. In this review, we discuss emerging evidence from rodents, non-human primates, and humans that demonstrates how cognitive aging affects the navigational computations supported by these systems. Critically, we show 1) that navigational deficits cannot solely be explained by general deficits in learning and memory, 2) that there is no uniform decline across different navigational computations, and 3) that navigational deficits might be sensitive markers for impending pathological decline. Following an introduction to the mechanisms underlying spatial navigation and how they relate to general processes of learning and memory, the review discusses how aging affects the perception and integration of spatial information, the creation and storage of memory traces for spatial information, and the use of spatial information during navigational behavior. The closing section highlights the clinical potential of behavioral and neural markers of spatial navigation, with a particular emphasis on neurodegenerative disorders.
536 _ _ |a 344 - Clinical and Health Care Research (POF3-344)
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542 _ _ |i 2017-08-01
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|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2018-08-30
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|u http://www.elsevier.com/open-access/userlicense/1.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 2 |a Aging: physiology
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Learning: physiology
|2 MeSH
650 _ 2 |a Neurodegenerative Diseases: physiopathology
|2 MeSH
650 _ 2 |a Spatial Memory: physiology
|2 MeSH
650 _ 2 |a Spatial Navigation: physiology
|2 MeSH
650 _ 2 |a Spatial Processing: physiology
|2 MeSH
700 1 _ |a Moffat, Scott D
|b 1
700 1 _ |a Wiener, Jan M
|b 2
700 1 _ |a Barnes, Carol A
|b 3
700 1 _ |a Wolbers, Thomas
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773 1 8 |a 10.1016/j.neuron.2017.06.037
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|t Neuron
|v 95
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773 _ _ |a 10.1016/j.neuron.2017.06.037
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856 7 _ |2 Pubmed Central
|u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5659315
856 4 _ |u https://pub.dzne.de/record/139476/files/DZNE-2020-05798_Restricted.pdf
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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