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@ARTICLE{Berron:139495,
      author       = {Berron, D. and Vieweg, P. and Hochkeppler, A. and Pluta, J.
                      B. and Ding, S-L and Maaß, Anne and Luther, A. and Xie, L.
                      and Das, S. R. and Wolk, D. A. and Wolbers, T. and
                      Yushkevich, P. A. and Düzel, E. and Wisse, L. E. M.},
      title        = {{A} protocol for manual segmentation of medial temporal
                      lobe subregions in 7 {T}esla {MRI}.},
      journal      = {NeuroImage: Clinical},
      volume       = {15},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {DZNE-2020-05817},
      pages        = {466-482},
      year         = {2017},
      abstract     = {Recent advances in MRI and increasing knowledge on the
                      characterization and anatomical variability of medial
                      temporal lobe (MTL) anatomy have paved the way for more
                      specific subdivisions of the MTL in humans. In addition,
                      recent studies suggest that early changes in many
                      neurodegenerative and neuropsychiatric diseases are better
                      detected in smaller subregions of the MTL rather than with
                      whole structure analyses. Here, we developed a new protocol
                      using 7 Tesla (T) MRI incorporating novel anatomical
                      findings for the manual segmentation of entorhinal cortex
                      (ErC), perirhinal cortex (PrC; divided into area 35 and 36),
                      parahippocampal cortex (PhC), and hippocampus; which
                      includes the subfields subiculum (Sub), CA1, CA2, as well as
                      CA3 and dentate gyrus (DG) which are separated by the
                      endfolial pathway covering most of the long axis of the
                      hippocampus. We provide detailed instructions alongside
                      slice-by-slice segmentations to ease learning for the
                      untrained but also more experienced raters. Twenty-two
                      subjects were scanned (19-32 yrs, mean age = 26 years, 12
                      females) with a turbo spin echo (TSE) T2-weighted MRI
                      sequence with high-resolution oblique coronal slices
                      oriented orthogonal to the long axis of the hippocampus
                      (in-plane resolution 0.44 × 0.44 mm2) and 1.0 mm slice
                      thickness. The scans were manually delineated by two
                      experienced raters, to assess intra- and inter-rater
                      reliability. The Dice Similarity Index (DSI) was above 0.78
                      for all regions and the Intraclass Correlation Coefficients
                      (ICC) were between 0.76 to 0.99 both for intra- and
                      inter-rater reliability. In conclusion, this study presents
                      a fine-grained and comprehensive segmentation protocol for
                      MTL structures at 7 T MRI that closely follows recent
                      knowledge from anatomical studies. More specific
                      subdivisions (e.g. area 35 and 36 in PrC, and the separation
                      of DG and CA3) may pave the way for more precise
                      delineations thereby enabling the detection of early
                      volumetric changes in dementia and neuropsychiatric
                      diseases.},
      keywords     = {Adult / Brain Mapping: methods / Brain Mapping: standards /
                      Dentate Gyrus: diagnostic imaging / Dentate Gyrus:
                      physiology / Female / Hippocampus: diagnostic imaging /
                      Hippocampus: physiology / Humans / Magnetic Resonance
                      Imaging: methods / Magnetic Resonance Imaging: standards /
                      Male / Temporal Lobe: diagnostic imaging / Temporal Lobe:
                      physiology / Young Adult},
      cin          = {AG Düzel / AG Wolbers / Core Technical Staff},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1310002 /
                      I:(DE-2719)1340007},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28652965},
      pmc          = {pmc:PMC5476466},
      doi          = {10.1016/j.nicl.2017.05.022},
      url          = {https://pub.dzne.de/record/139495},
}