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@ARTICLE{Maa:139503,
      author       = {Maaß, Anne and Landau, Susan and Baker, Suzanne L and
                      Horng, Andy and Lockhart, Samuel N and La Joie, Renaud and
                      Rabinovici, Gil D and Jagust, William J and Initiative,
                      Alzheimer's Disease Neuroimaging},
      title        = {{C}omparison of multiple tau-{PET} measures as biomarkers
                      in aging and {A}lzheimer's disease.},
      journal      = {NeuroImage},
      volume       = {157},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {DZNE-2020-05825},
      pages        = {448-463},
      year         = {2017},
      abstract     = {The recent development of tau-specific positron emission
                      tomography (PET) tracers enables in vivo quantification of
                      regional tau pathology, one of the key lesions in
                      Alzheimer's disease (AD). Tau PET imaging may become a
                      useful biomarker for clinical diagnosis and tracking of
                      disease progression but there is no consensus yet on how tau
                      PET signal is best quantified. The goal of the current study
                      was to evaluate multiple whole-brain and region-specific
                      approaches to detect clinically relevant tau PET signal. Two
                      independent cohorts of cognitively normal adults and
                      amyloid-positive (Aβ+) patients with mild cognitive
                      impairment (MCI) or AD-dementia underwent [18F]AV-1451 PET.
                      Methods for tau tracer quantification included: (i) in vivo
                      Braak staging, (ii) regional uptake in Braak composite
                      regions, (iii) several whole-brain measures of tracer
                      uptake, (iv) regional uptake in AD-vulnerable voxels, and
                      (v) uptake in a priori defined regions. Receiver operating
                      curves characterized accuracy in distinguishing Aβ-
                      controls from AD/MCI patients and yielded tau positivity
                      cutoffs. Clinical relevance of tau PET measures was assessed
                      by regressions against cognition and MR imaging measures.
                      Key tracer uptake patterns were identified by a factor
                      analysis and voxel-wise contrasts. Braak staging, global and
                      region-specific tau measures yielded similar diagnostic
                      accuracies, which differed between cohorts. While all tau
                      measures were related to amyloid and global cognition,
                      memory and hippocampal/entorhinal volume/thickness were
                      associated with regional tracer retention in the medial
                      temporal lobe. Key regions of tau accumulation included
                      medial temporal and inferior/middle temporal regions,
                      retrosplenial cortex, and banks of the superior temporal
                      sulcus. Our data indicate that whole-brain tau PET measures
                      might be adequate biomarkers to detect AD-related tau
                      pathology. However, regional measures covering AD-vulnerable
                      regions may increase sensitivity to early tau PET signal,
                      atrophy and memory decline.},
      keywords     = {Adult / Age of Onset / Aged / Aged, 80 and over / Aging:
                      metabolism / Alzheimer Disease: diagnostic imaging /
                      Alzheimer Disease: metabolism / Alzheimer Disease: pathology
                      / Alzheimer Disease: physiopathology / Amyloid
                      beta-Peptides: metabolism / Carbolines / Cognitive
                      Dysfunction: diagnostic imaging / Cognitive Dysfunction:
                      metabolism / Cognitive Dysfunction: pathology / Cognitive
                      Dysfunction: physiopathology / Cohort Studies / Female /
                      Humans / Male / Middle Aged / Neocortex: diagnostic imaging
                      / Neocortex: metabolism / Positron-Emission Tomography:
                      methods / Severity of Illness Index / Young Adult / tau
                      Proteins: metabolism / Amyloid beta-Peptides (NLM Chemicals)
                      / Carbolines (NLM Chemicals) / tau Proteins (NLM Chemicals)
                      / 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (NLM
                      Chemicals)},
      cin          = {AG Düzel},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28587897},
      pmc          = {pmc:PMC5814575},
      doi          = {10.1016/j.neuroimage.2017.05.058},
      url          = {https://pub.dzne.de/record/139503},
}