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| Home > Publications Database > The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice. > print |
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| 001 | 139529 | ||
| 005 | 20240511120146.0 | ||
| 024 | 7 | _ | |a 10.1038/tp.2017.202 |2 doi |
| 024 | 7 | _ | |a pmid:28949335 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5639246 |2 pmc |
| 024 | 7 | _ | |a altmetric:26607141 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-05851 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Benito, E. |0 P:(DE-2719)2810482 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a The BET/BRD inhibitor JQ1 improves brain plasticity in WT and APP mice. |
| 260 | _ | _ | |a London |c 2017 |b Nature Publishing Group |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2017-09-26 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2017-09-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1715350888_4831 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Histone acetylation is essential for memory formation and its deregulation contributes to the pathogenesis of Alzheimer's disease. Thus, targeting histone acetylation is discussed as a novel approach to treat dementia. The histone acetylation landscape is shaped by chromatin writer and eraser proteins, while readers link chromatin state to cellular function. Chromatin readers emerged novel drug targets in cancer research but little is known about the manipulation of readers in the adult brain. Here we tested the effect of JQ1-a small-molecule inhibitor of the chromatin readers BRD2, BRD3, BRD4 and BRDT-on brain function and show that JQ1 is able to enhance cognitive performance and long-term potentiation in wild-type animals and in a mouse model for Alzheimer's disease. Systemic administration of JQ1 elicited a hippocampal gene expression program that is associated with ion channel activity, transcription and DNA repair. Our findings suggest that JQ1 could be used as a therapy against dementia and should be further tested in the context of learning and memory. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2017-09-01 |2 Crossref |u https://creativecommons.org/licenses/by/4.0 |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a (+)-JQ1 compound |2 NLM Chemicals |
| 650 | _ | 7 | |a Amyloid beta-Protein Precursor |2 NLM Chemicals |
| 650 | _ | 7 | |a Azepines |2 NLM Chemicals |
| 650 | _ | 7 | |a BRDT protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Brd2 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Brd3 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Brd4 protein, mouse |2 NLM Chemicals |
| 650 | _ | 7 | |a Chromosomal Proteins, Non-Histone |2 NLM Chemicals |
| 650 | _ | 7 | |a Nuclear Proteins |2 NLM Chemicals |
| 650 | _ | 7 | |a Transcription Factors |2 NLM Chemicals |
| 650 | _ | 7 | |a Triazoles |2 NLM Chemicals |
| 650 | _ | 2 | |a Alzheimer Disease: genetics |2 MeSH |
| 650 | _ | 2 | |a Amyloid beta-Protein Precursor: genetics |2 MeSH |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Azepines: administration & dosage |2 MeSH |
| 650 | _ | 2 | |a Behavior, Animal: drug effects |2 MeSH |
| 650 | _ | 2 | |a Chromosomal Proteins, Non-Histone: antagonists & inhibitors |2 MeSH |
| 650 | _ | 2 | |a Gene Expression: drug effects |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: drug effects |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: metabolism |2 MeSH |
| 650 | _ | 2 | |a Hippocampus: physiology |2 MeSH |
| 650 | _ | 2 | |a Long-Term Potentiation: drug effects |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Memory: drug effects |2 MeSH |
| 650 | _ | 2 | |a Memory: physiology |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Mice, Transgenic |2 MeSH |
| 650 | _ | 2 | |a Nuclear Proteins: antagonists & inhibitors |2 MeSH |
| 650 | _ | 2 | |a Transcription Factors: antagonists & inhibitors |2 MeSH |
| 650 | _ | 2 | |a Triazoles: administration & dosage |2 MeSH |
| 700 | 1 | _ | |a Ramachandran, B. |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Schroeder, H. |0 P:(DE-2719)2812036 |b 2 |u dzne |
| 700 | 1 | _ | |a Schmidt, G. |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Urbanke, H. |0 P:(DE-2719)2811034 |b 4 |u dzne |
| 700 | 1 | _ | |a Burkhardt, S. |0 P:(DE-2719)2810773 |b 5 |u dzne |
| 700 | 1 | _ | |a Capece, V. |0 P:(DE-2719)2810626 |b 6 |u dzne |
| 700 | 1 | _ | |a Dean, C. |0 P:(DE-HGF)0 |b 7 |
| 700 | 1 | _ | |a Fischer, A. |0 P:(DE-2719)2000047 |b 8 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1038/tp.2017.202 |b : Springer Science and Business Media LLC, 2017-09-01 |n 9 |p e1239-e1239 |3 journal-article |2 Crossref |t Translational Psychiatry |v 7 |y 2017 |x 2158-3188 |
| 773 | _ | _ | |a 10.1038/tp.2017.202 |g Vol. 7, no. 9, p. e1239 - e1239 |0 PERI:(DE-600)2609311-X |n 9 |q 7:9 |t Translational Psychiatry |v 7 |y 2017 |x 2158-3188 |
| 856 | 4 | _ | |y OpenAccess |u https://pub.dzne.de/record/139529/files/DZNE-2020-05851.pdf |
| 856 | 4 | _ | |y OpenAccess |x pdfa |u https://pub.dzne.de/record/139529/files/DZNE-2020-05851.pdf?subformat=pdfa |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5639246 |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2810482 |
| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 2 |6 P:(DE-2719)2812036 |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 8 |6 P:(DE-2719)2000047 |
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| 914 | 1 | _ | |y 2017 |
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| 920 | 1 | _ | |0 I:(DE-2719)1410002 |k AG Fischer |l Epigenetics and Systems Medicine in Neurodegenerative Diseases |x 0 |
| 920 | 1 | _ | |0 I:(DE-2719)1440012 |k AG Bonn 2 |l Computational Systems Biology |x 1 |
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| 980 | 1 | _ | |a FullTexts |
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