000139531 001__ 139531
000139531 005__ 20240619121038.0
000139531 0247_ $$2doi$$a10.15252/embj.201796821
000139531 0247_ $$2pmid$$apmid:28768717
000139531 0247_ $$2pmc$$apmc:PMC5623844
000139531 0247_ $$2ISSN$$a0261-4189
000139531 0247_ $$2ISSN$$a1460-2075
000139531 0247_ $$2altmetric$$aaltmetric:23369632
000139531 037__ $$aDZNE-2020-05853
000139531 041__ $$aEnglish
000139531 082__ $$a570
000139531 1001_ $$0P:(DE-2719)9000006$$aAgís-Balboa, Roberto Carlos$$b0$$eFirst author$$udzne
000139531 245__ $$aFormin 2 links neuropsychiatric phenotypes at young age to an increased risk for dementia.
000139531 260__ $$aHoboken, NJ [u.a.]$$bWiley$$c2017
000139531 264_1 $$2Crossref$$3online$$bEMBO$$c2017-08-02
000139531 264_1 $$2Crossref$$3print$$bEMBO$$c2017-10-02
000139531 3367_ $$2DRIVER$$aarticle
000139531 3367_ $$2DataCite$$aOutput Types/Journal article
000139531 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1718785111_8362
000139531 3367_ $$2BibTeX$$aARTICLE
000139531 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000139531 3367_ $$00$$2EndNote$$aJournal Article
000139531 520__ $$aAge-associated memory decline is due to variable combinations of genetic and environmental risk factors. How these risk factors interact to drive disease onset is currently unknown. Here we begin to elucidate the mechanisms by which post-traumatic stress disorder (PTSD) at a young age contributes to an increased risk to develop dementia at old age. We show that the actin nucleator Formin 2 (Fmn2) is deregulated in PTSD and in Alzheimer's disease (AD) patients. Young mice lacking the Fmn2 gene exhibit PTSD-like phenotypes and corresponding impairments of synaptic plasticity, while the consolidation of new memories is unaffected. However, Fmn2 mutant mice develop accelerated age-associated memory decline that is further increased in the presence of additional risk factors and is mechanistically linked to a loss of transcriptional homeostasis. In conclusion, our data present a new approach to explore the connection between AD risk factors across life span and provide mechanistic insight to the processes by which neuropsychiatric diseases at a young age affect the risk for developing dementia.
000139531 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000139531 542__ $$2Crossref$$i2017-08-02$$uhttp://creativecommons.org/licenses/by/4.0/
000139531 542__ $$2Crossref$$i2017-08-02$$uhttp://doi.wiley.com/10.1002/tdm_license_1.1
000139531 588__ $$aDataset connected to CrossRef, PubMed,
000139531 650_7 $$2NLM Chemicals$$aFormins
000139531 650_7 $$2NLM Chemicals$$aMicrofilament Proteins
000139531 650_7 $$2NLM Chemicals$$aNerve Tissue Proteins
000139531 650_7 $$2NLM Chemicals$$aNuclear Proteins
000139531 650_7 $$2NLM Chemicals$$aformin 2 protein, mouse
000139531 650_2 $$2MeSH$$aAdult
000139531 650_2 $$2MeSH$$aAge of Onset
000139531 650_2 $$2MeSH$$aAging: genetics
000139531 650_2 $$2MeSH$$aAging: physiology
000139531 650_2 $$2MeSH$$aAnimals
000139531 650_2 $$2MeSH$$aCase-Control Studies
000139531 650_2 $$2MeSH$$aDementia: epidemiology
000139531 650_2 $$2MeSH$$aDementia: genetics
000139531 650_2 $$2MeSH$$aDementia: psychology
000139531 650_2 $$2MeSH$$aFormins
000139531 650_2 $$2MeSH$$aHumans
000139531 650_2 $$2MeSH$$aMale
000139531 650_2 $$2MeSH$$aMemory: physiology
000139531 650_2 $$2MeSH$$aMice
000139531 650_2 $$2MeSH$$aMice, Knockout
000139531 650_2 $$2MeSH$$aMicrofilament Proteins: genetics
000139531 650_2 $$2MeSH$$aMiddle Aged
000139531 650_2 $$2MeSH$$aNerve Tissue Proteins
000139531 650_2 $$2MeSH$$aNeuronal Plasticity: genetics
000139531 650_2 $$2MeSH$$aNuclear Proteins: genetics
000139531 650_2 $$2MeSH$$aPhenotype
000139531 650_2 $$2MeSH$$aRisk Factors
000139531 650_2 $$2MeSH$$aStress Disorders, Post-Traumatic: complications
000139531 650_2 $$2MeSH$$aStress Disorders, Post-Traumatic: epidemiology
000139531 650_2 $$2MeSH$$aStress Disorders, Post-Traumatic: genetics
000139531 7001_ $$0P:(DE-HGF)0$$aPinheiro, Paulo S$$b1
000139531 7001_ $$0P:(DE-HGF)0$$aRebola, Nelson$$b2
000139531 7001_ $$0P:(DE-2719)2812366$$aKerimoglu, Cemil$$b3$$udzne
000139531 7001_ $$0P:(DE-2719)2810482$$aBenito, Eva$$b4$$udzne
000139531 7001_ $$0P:(DE-2719)2810722$$aGertig, Michael$$b5$$udzne
000139531 7001_ $$0P:(DE-HGF)0$$aBahari-Javan, Sanaz$$b6
000139531 7001_ $$0P:(DE-2719)2811223$$aJain, Gaurav$$b7$$udzne
000139531 7001_ $$0P:(DE-2719)2810773$$aBurkhardt, Susanne$$b8$$udzne
000139531 7001_ $$0P:(DE-HGF)0$$aDelalle, Ivana$$b9
000139531 7001_ $$0P:(DE-HGF)0$$aJatzko, Alexander$$b10
000139531 7001_ $$0P:(DE-HGF)0$$aDettenhofer, Markus$$b11
000139531 7001_ $$0P:(DE-HGF)0$$aZunszain, Patricia A$$b12
000139531 7001_ $$0P:(DE-HGF)0$$aSchmitt, Andrea$$b13
000139531 7001_ $$0P:(DE-HGF)0$$aFalkai, Peter$$b14
000139531 7001_ $$0P:(DE-HGF)0$$aPape, Julius C$$b15
000139531 7001_ $$0P:(DE-HGF)0$$aBinder, Elisabeth B$$b16
000139531 7001_ $$0P:(DE-HGF)0$$aMulle, Christophe$$b17
000139531 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b18$$eCorresponding author$$udzne
000139531 7001_ $$0P:(DE-2719)2811099$$aSananbenesi, Farahnaz$$b19$$eLast author$$udzne
000139531 77318 $$2Crossref$$3journal-article$$a10.15252/embj.201796821$$b : EMBO, 2017-08-02$$n19$$p2815-2828$$tThe EMBO Journal$$v36$$x0261-4189$$y2017
000139531 773__ $$0PERI:(DE-600)1467419-1$$a10.15252/embj.201796821$$gVol. 36, no. 19, p. 2815 - 2828$$n19$$p2815-2828$$q36:19<2815 - 2828$$tThe EMBO journal$$v36$$x0261-4189$$y2017
000139531 8564_ $$uhttps://pub.dzne.de/record/139531/files/DZNE-2020-05853.pdf$$yOpenAccess
000139531 8564_ $$uhttps://pub.dzne.de/record/139531/files/DZNE-2020-05853.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000139531 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5623844
000139531 909CO $$ooai:pub.dzne.de:139531$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000139531 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000006$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000139531 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812366$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE
000139531 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810482$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b4$$kDZNE
000139531 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810722$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE
000139531 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811223$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000139531 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810773$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b8$$kDZNE
000139531 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000047$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b18$$kDZNE
000139531 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811099$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b19$$kDZNE
000139531 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000139531 9141_ $$y2017
000139531 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-12
000139531 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-12
000139531 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000139531 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2022-11-12
000139531 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEMBO J : 2021$$d2022-11-12
000139531 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bEMBO J : 2021$$d2022-11-12
000139531 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-12
000139531 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-12
000139531 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000139531 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2022-11-12
000139531 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-12
000139531 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-12
000139531 9201_ $$0I:(DE-2719)1410004$$kAG Sananbenesi$$lGenome Dynamics in Neurodegenerative Diseases$$x0
000139531 9201_ $$0I:(DE-2719)1410002$$kAG Fischer$$lEpigenetics and Systems Medicine in Neurodegenerative Diseases$$x1
000139531 9201_ $$0I:(DE-2719)1440012$$kAG Bonn 2$$lComputational Systems Biology$$x2
000139531 980__ $$ajournal
000139531 980__ $$aVDB
000139531 980__ $$aUNRESTRICTED
000139531 980__ $$aI:(DE-2719)1410004
000139531 980__ $$aI:(DE-2719)1410002
000139531 980__ $$aI:(DE-2719)1440012
000139531 9801_ $$aFullTexts
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ejmg.2013.10.003$$o10.1016/j.ejmg.2013.10.003
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.0079-12.2012$$o10.1523/JNEUROSCI.0079-12.2012
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/nar/gkp335$$o10.1093/nar/gkp335
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1056/NEJMoa1202753$$o10.1056/NEJMoa1202753
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI79942$$o10.1172/JCI79942
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/978-1-4939-6424-6_13$$o10.1007/978-1-4939-6424-6_13
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fnins.2011.00035$$o10.3389/fnins.2011.00035
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M308254200$$o10.1074/jbc.M308254200
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0057826$$o10.1371/journal.pone.0057826
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neubiorev.2016.08.018$$o10.1016/j.neubiorev.2016.08.018
000139531 999C5 $$2Crossref$$oCitron BA 2015$$y2015
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/sj.mp.4001679$$o10.1038/sj.mp.4001679
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fpsyt.2015.00032$$o10.3389/fpsyt.2015.00032
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/pr.2015.19$$o10.1038/pr.2015.19
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.5112-03.2004$$o10.1523/JNEUROSCI.5112-03.2004
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.nlm.2006.08.003$$o10.1016/j.nlm.2006.08.003
000139531 999C5 $$2Crossref$$oFischer A Post traumatic stress disorders basic science and clinical disorder 2008$$tPost traumatic stress disorders basic science and clinical disorder$$y2008
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/embj.201387637$$o10.1002/embj.201387637
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/jts.2490060405$$o10.1002/jts.2490060405
000139531 999C5 $$2Crossref$$o
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuropharm.2016.02.008$$o10.1016/j.neuropharm.2016.02.008
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fnins.2013.00089$$o10.3389/fnins.2013.00089
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3233/JAD-2011-110080$$o10.3233/JAD-2011-110080
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/emmm.201201923$$o10.1002/emmm.201201923
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature07925$$o10.1038/nature07925
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.20-13-j0001.2000$$o10.1523/JNEUROSCI.20-13-j0001.2000
000139531 999C5 $$2Crossref$$oHautzinger M 1991$$y1991
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1460-9568.2009.07004.x$$o10.1111/j.1460-9568.2009.07004.x
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1097/00006842-197905000-00004$$o10.1097/00006842-197905000-00004
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1097/01.WCB.0000125888.56462.A1$$o10.1097/01.WCB.0000125888.56462.A1
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tins.2009.04.001$$o10.1016/j.tins.2009.04.001
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.3356-12.2013$$o10.1523/JNEUROSCI.3356-12.2013
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/npp.2009.197$$o10.1038/npp.2009.197
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0710548105$$o10.1073/pnas.0710548105
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/acel.12012$$o10.1111/acel.12012
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00204-015-1472-2$$o10.1007/s00204-015-1472-2
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1101/lm.037291.114$$o10.1101/lm.037291.114
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.nbd.2016.02.009$$o10.1016/j.nbd.2016.02.009
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.biopsych.2006.05.038$$o10.1016/j.biopsych.2006.05.038
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.ajhg.2014.10.016$$o10.1016/j.ajhg.2014.10.016
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncb880$$o10.1038/ncb880
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/bioinformatics/btr189$$o10.1093/bioinformatics/btr189
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M115.681379$$o10.1074/jbc.M115.681379
000139531 999C5 $$2Crossref$$oMyers KM 2002$$y2002
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.nbd.2006.12.008$$o10.1016/j.nbd.2006.12.008
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrm2890$$o10.1038/nrm2890
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/cercor/bhn101$$o10.1093/cercor/bhn101
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1186088$$o10.1126/science.1186088
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cub.2011.04.029$$o10.1016/j.cub.2011.04.029
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2894-13.2014$$o10.1523/JNEUROSCI.2894-13.2014
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/sj.embor.7400784$$o10.1038/sj.embor.7400784
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1515/REVNEURO.2010.21.1.1$$o10.1515/REVNEURO.2010.21.1.1
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fnmol.2013.00039$$o10.3389/fnmol.2013.00039
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1242/dev.130104$$o10.1242/dev.130104
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.febslet.2007.06.006$$o10.1016/j.febslet.2007.06.006
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1006/mcne.2002.1188$$o10.1006/mcne.2002.1188
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn1943$$o10.1038/nn1943
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1515/BC.2009.131$$o10.1515/BC.2009.131
000139531 999C5 $$2Crossref$$oSchmitt A 2016$$y2016
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1023/A:1020922023090$$o10.1023/A:1020922023090
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/ncb2353$$o10.1038/ncb2353
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.modgep.2003.11.006$$o10.1016/j.modgep.2003.11.006
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/ajmg.b.32278$$o10.1002/ajmg.b.32278
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.3389/fncel.2014.00373$$o10.3389/fncel.2014.00373
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.15252/embj.201487870$$o10.15252/embj.201487870
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.expneurol.2012.10.005$$o10.1016/j.expneurol.2012.10.005
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.conb.2004.04.001$$o10.1016/j.conb.2004.04.001
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.2641-12.2013$$o10.1523/JNEUROSCI.2641-12.2013
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuint.2013.08.011$$o10.1016/j.neuint.2013.08.011
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tins.2011.10.003$$o10.1016/j.tins.2011.10.003
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.4119-07.2007$$o10.1523/JNEUROSCI.4119-07.2007
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s11064-016-1903-3$$o10.1007/s11064-016-1903-3
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2013.03.005$$o10.1016/j.jalz.2013.03.005
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuropharm.2012.06.001$$o10.1016/j.neuropharm.2012.06.001
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1042/BST20130233$$o10.1042/BST20130233
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1001/archgenpsychiatry.2010.61$$o10.1001/archgenpsychiatry.2010.61
000139531 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/sj.mp.4001905$$o10.1038/sj.mp.4001905