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@ARTICLE{AgsBalboa:139531,
      author       = {Agís-Balboa, Roberto Carlos and Pinheiro, Paulo S and
                      Rebola, Nelson and Kerimoglu, Cemil and Benito, Eva and
                      Gertig, Michael and Bahari-Javan, Sanaz and Jain, Gaurav and
                      Burkhardt, Susanne and Delalle, Ivana and Jatzko, Alexander
                      and Dettenhofer, Markus and Zunszain, Patricia A and
                      Schmitt, Andrea and Falkai, Peter and Pape, Julius C and
                      Binder, Elisabeth B and Mulle, Christophe and Fischer, Andre
                      and Sananbenesi, Farahnaz},
      title        = {{F}ormin 2 links neuropsychiatric phenotypes at young age
                      to an increased risk for dementia.},
      journal      = {The EMBO journal},
      volume       = {36},
      number       = {19},
      issn         = {0261-4189},
      address      = {Hoboken, NJ [u.a.]},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-05853},
      pages        = {2815-2828},
      year         = {2017},
      abstract     = {Age-associated memory decline is due to variable
                      combinations of genetic and environmental risk factors. How
                      these risk factors interact to drive disease onset is
                      currently unknown. Here we begin to elucidate the mechanisms
                      by which post-traumatic stress disorder (PTSD) at a young
                      age contributes to an increased risk to develop dementia at
                      old age. We show that the actin nucleator Formin 2 (Fmn2) is
                      deregulated in PTSD and in Alzheimer's disease (AD)
                      patients. Young mice lacking the Fmn2 gene exhibit PTSD-like
                      phenotypes and corresponding impairments of synaptic
                      plasticity, while the consolidation of new memories is
                      unaffected. However, Fmn2 mutant mice develop accelerated
                      age-associated memory decline that is further increased in
                      the presence of additional risk factors and is
                      mechanistically linked to a loss of transcriptional
                      homeostasis. In conclusion, our data present a new approach
                      to explore the connection between AD risk factors across
                      life span and provide mechanistic insight to the processes
                      by which neuropsychiatric diseases at a young age affect the
                      risk for developing dementia.},
      keywords     = {Adult / Age of Onset / Aging: genetics / Aging: physiology
                      / Animals / Case-Control Studies / Dementia: epidemiology /
                      Dementia: genetics / Dementia: psychology / Formins / Humans
                      / Male / Memory: physiology / Mice / Mice, Knockout /
                      Microfilament Proteins: genetics / Middle Aged / Nerve
                      Tissue Proteins / Neuronal Plasticity: genetics / Nuclear
                      Proteins: genetics / Phenotype / Risk Factors / Stress
                      Disorders, Post-Traumatic: complications / Stress Disorders,
                      Post-Traumatic: epidemiology / Stress Disorders,
                      Post-Traumatic: genetics / Formins (NLM Chemicals) /
                      Microfilament Proteins (NLM Chemicals) / Nerve Tissue
                      Proteins (NLM Chemicals) / Nuclear Proteins (NLM Chemicals)
                      / formin 2 protein, mouse (NLM Chemicals)},
      cin          = {AG Sananbenesi / AG Fischer / AG Bonn 2},
      ddc          = {570},
      cid          = {I:(DE-2719)1410004 / I:(DE-2719)1410002 /
                      I:(DE-2719)1440012},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28768717},
      pmc          = {pmc:PMC5623844},
      doi          = {10.15252/embj.201796821},
      url          = {https://pub.dzne.de/record/139531},
}