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@ARTICLE{Wucherer:139547,
      author       = {Wucherer, D. and Thyrian, J. R. and Eichler, T. and Hertel,
                      J. and Kilimann, I. and Richter, Steffen and Michalowsky, B.
                      and Zwingmann, I. and Dreier-Wolfgramm, A. and Ritter, C. A.
                      and Teipel, S. and Hoffmann, W.},
      title        = {{D}rug-related problems in community-dwelling primary care
                      patients screened positive for dementia.},
      journal      = {International psychogeriatrics},
      volume       = {29},
      number       = {11},
      issn         = {1041-6102},
      address      = {Cambridge},
      publisher    = {Cambridge Univ. Press},
      reportid     = {DZNE-2020-05869},
      pages        = {1857-1868},
      year         = {2017},
      abstract     = {Older people have a higher risk of drug-related problems
                      (DRPs). However, little is known about the prevalence of
                      DRPs in community-dwelling people who screened positive for
                      dementia. Our study aimed to determine (1) the prevalence
                      and types of DRPs and (2) the socio-demographic and clinical
                      variables associated with DRPs in people screened positive
                      for dementia in primary care.The Dementia: life- and
                      person-centered help in Mecklenburg-Western Pomerania
                      (DelpHi-MV) study is a general practitioner (GP)-based
                      cluster-randomized controlled intervention study to
                      implement and evaluate an innovative concept of
                      collaborative dementia care management in the primary care
                      setting in Germany. Medication reviews of 446 study
                      participants were conducted by pharmacists based on a
                      comprehensive baseline assessment that included a
                      computer-based home medication assessment.
                      ClinicalTrials.gov Identifier: NCT01401582.A total of 1,077
                      DRPs were documented. In 414 study participants $(93\%),$ at
                      least one DRP was detected by a pharmacist. The most
                      frequent DRPs were administration and compliance problems
                      $(60\%),$ drug interactions $(17\%),$ and problems with
                      inappropriate drug choice $(15\%).$ The number of DRPs was
                      significantly associated with the total number of drugs
                      taken and with a formal diagnosis of a mental or behavioral
                      disorder.Degree of cognitive impairment (MMSE defined) and
                      formal diagnosis of dementia were not risk factors for an
                      increased number of DRPs. However, the total number of drug
                      taken and the presence of a diagnosis of mental and
                      behavioral disorders were associated with an increased total
                      number of DRPs.},
      keywords     = {Aged / Aged, 80 and over / Cognitive Dysfunction:
                      epidemiology / Cross-Sectional Studies / Dementia:
                      epidemiology / Drug-Related Side Effects and Adverse
                      Reactions: classification / Drug-Related Side Effects and
                      Adverse Reactions: epidemiology / Female / Germany:
                      epidemiology / Humans / Independent Living / Logistic Models
                      / Male / Multivariate Analysis / Primary Health Care:
                      organization $\&$ administration / Psychiatric Status Rating
                      Scales / Randomized Controlled Trials as Topic},
      cin          = {AG Grabe / AG Thyrian / Clinical Dementia Research Rostock
                      /Greifswald ; AG Teipel / Translational Health Care Research
                      / Magdeburg Pre 2020},
      ddc          = {610},
      cid          = {I:(DE-2719)5000001 / I:(DE-2719)1510800 /
                      I:(DE-2719)1510100 / I:(DE-2719)1510600 /
                      I:(DE-2719)6000015},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28780910},
      pmc          = {pmc:PMC5647675},
      doi          = {10.1017/S1041610217001442},
      url          = {https://pub.dzne.de/record/139547},
}