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000139570 037__ $$aDZNE-2020-05892
000139570 041__ $$aEnglish
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000139570 1001_ $$aMentrup, Torben$$b0
000139570 245__ $$aSignal peptide peptidase and SPP-like proteases - Possible therapeutic targets?
000139570 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2017
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000139570 520__ $$aSignal peptide peptidase (SPP) and the four homologous SPP-like proteases SPPL2a, SPPL2b, SPPL2c and SPPL3 are GxGD-type intramembrane-cleaving proteases (I-CLIPs). In addition to divergent subcellular localisations, distinct differences in the mechanistic properties and substrate requirements of individual family members have been unravelled. SPP/SPPL proteases employ a catalytic mechanism related to that of the γ-secretase complex. Nevertheless, differential targeting of SPP/SPPL proteases and γ-secretase by inhibitors has been demonstrated. Furthermore, also within the SPP/SPPL family significant differences in the sensitivity to currently available inhibitory compounds have been reported. Though far from complete, our knowledge on pathophysiological functions of SPP/SPPL proteases, in particular based on studies in mice, has been significantly increased over the last years. Based on this, inhibition of distinct SPP/SPPL proteases has been proposed as a novel therapeutic concept e.g. for the treatment of autoimmunity and viral or protozoal infections, as we will discuss in this review. This article is part of a Special Issue entitled: Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John.
000139570 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000139570 542__ $$2Crossref$$i2017-11-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
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000139570 650_7 $$2NLM Chemicals$$aMembrane Proteins
000139570 650_7 $$2NLM Chemicals$$aPeptides
000139570 650_7 $$2NLM Chemicals$$adermcidin
000139570 650_7 $$0EC 3.4.-$$2NLM Chemicals$$aAmyloid Precursor Protein Secretases
000139570 650_7 $$0EC 3.4.23.-$$2NLM Chemicals$$aAspartic Acid Endopeptidases
000139570 650_7 $$0EC 3.4.23.-$$2NLM Chemicals$$aSPPL2a protein, human
000139570 650_7 $$0EC 3.4.23.-$$2NLM Chemicals$$aSPPL2b protein, human
000139570 650_2 $$2MeSH$$aAmino Acid Sequence: genetics
000139570 650_2 $$2MeSH$$aAmyloid Precursor Protein Secretases: antagonists & inhibitors
000139570 650_2 $$2MeSH$$aAmyloid Precursor Protein Secretases: genetics
000139570 650_2 $$2MeSH$$aAspartic Acid Endopeptidases: antagonists & inhibitors
000139570 650_2 $$2MeSH$$aAspartic Acid Endopeptidases: genetics
000139570 650_2 $$2MeSH$$aHumans
000139570 650_2 $$2MeSH$$aMembrane Proteins: antagonists & inhibitors
000139570 650_2 $$2MeSH$$aMembrane Proteins: genetics
000139570 650_2 $$2MeSH$$aPeptides: antagonists & inhibitors
000139570 650_2 $$2MeSH$$aPeptides: genetics
000139570 650_2 $$2MeSH$$aPeptides: metabolism
000139570 650_2 $$2MeSH$$aProteolysis
000139570 650_2 $$2MeSH$$aSubstrate Specificity
000139570 7001_ $$aLoock, Ann-Christine$$b1
000139570 7001_ $$0P:(DE-2719)2000007$$aFluhrer, Regina$$b2$$udzne
000139570 7001_ $$0P:(DE-HGF)0$$aSchröder, Bernd$$b3$$eCorresponding author
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000139570 773__ $$0PERI:(DE-600)2209512-3$$a10.1016/j.bbamcr.2017.06.007$$gVol. 1864, no. 11 Pt B, p. 2169 - 2182$$n11$$p2169-2182$$q1864:11 Pt B<2169 - 2182$$tBiochimica et biophysica acta / Molecular cell research$$v1864$$x0167-4889$$y2017
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