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000139622 0247_ $$2doi$$a10.1007/s00391-017-1225-3
000139622 0247_ $$2pmid$$apmid:28405748
000139622 0247_ $$2ISSN$$a0044-281X
000139622 0247_ $$2ISSN$$a0948-6704
000139622 0247_ $$2ISSN$$a1435-1269
000139622 037__ $$aDZNE-2020-05944
000139622 041__ $$aEnglish
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000139622 1001_ $$0P:(DE-2719)2810394$$aKilimann, Ingo$$b0$$eFirst author$$udzne
000139622 245__ $$aTranslation of imaging biomarkers from clinical research to healthcare.
000139622 260__ $$aHeidelberg$$bSpringer Medizin$$c2017
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000139622 520__ $$aThe use of biomarkers for diagnostics of Alzheimer's disease (AD) has increased over the last years in specialized care and experimental settings. With the possibly upcoming availability of disease-modifying therapeutic agents, the diagnostics and treatment of patients with cognitive impairment will change. Biomarkers will be used as theranostic markers for case finding. The development and evaluation of biomarkers can be framed in a phase model from preclinical studies through trials in expert center settings to the evaluation of biomarkers in primary care, up to testing the efficacy and the impact of biomarkers on the healthcare system. Hippocampal volumetry is the most accepted and in-depth tested biomarker for AD diagnostics and prediction of the course. Therefore, hippocampus volumetry is used to illustrate the phase model of biomarker development and present the milestones already achieved and questions still to be resolved.
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000139622 650_7 $$2NLM Chemicals$$aBiomarkers
000139622 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging
000139622 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000139622 650_2 $$2MeSH$$aAlzheimer Disease: pathology
000139622 650_2 $$2MeSH$$aBiomarkers: cerebrospinal fluid
000139622 650_2 $$2MeSH$$aBrain: diagnostic imaging
000139622 650_2 $$2MeSH$$aBrain: metabolism
000139622 650_2 $$2MeSH$$aBrain: pathology
000139622 650_2 $$2MeSH$$aHealth Services Research: organization & administration
000139622 650_2 $$2MeSH$$aHumans
000139622 650_2 $$2MeSH$$aMolecular Imaging: methods
000139622 650_2 $$2MeSH$$aPositron-Emission Tomography: methods
000139622 650_2 $$2MeSH$$aReproducibility of Results
000139622 650_2 $$2MeSH$$aSensitivity and Specificity
000139622 650_2 $$2MeSH$$aTranslational Medical Research: organization & administration
000139622 7001_ $$0P:(DE-2719)2290613$$aThyrian, Jochen René$$b1$$udzne
000139622 7001_ $$0P:(DE-2719)2000040$$aHoffmann, Wolfgang$$b2$$udzne
000139622 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan J$$b3$$eLast author$$udzne
000139622 77318 $$2Crossref$$3journal-article$$a10.1007/s00391-017-1225-3$$b : Springer Science and Business Media LLC, 2017-04-12$$nS2$$p84-88$$tZeitschrift für Gerontologie und Geriatrie$$v50$$x0948-6704$$y2017
000139622 773__ $$0PERI:(DE-600)1463317-6$$a10.1007/s00391-017-1225-3$$gVol. 50, no. Suppl 2, p. 84 - 88$$nS2$$p84-88$$q50:Suppl 2<84 - 88$$tZeitschrift für Gerontologie und Geriatrie$$v50$$x0948-6704$$y2017
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000139622 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neurobiolaging.2013.02.002$$o10.1016/j.neurobiolaging.2013.02.002
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000139622 999C5 $$2Crossref$$oMJ Leon De 1993$$y1993
000139622 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.jalz.2014.05.1756$$o10.1016/j.jalz.2014.05.1756
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