TY  - JOUR
AU  - Kilimann, Ingo
AU  - Thyrian, Jochen René
AU  - Hoffmann, Wolfgang
AU  - Teipel, Stefan J
TI  - Translation of imaging biomarkers from clinical research to healthcare.
JO  - Zeitschrift für Gerontologie und Geriatrie
VL  - 50
IS  - S2
SN  - 0948-6704
CY  - Heidelberg
PB  - Springer Medizin
M1  - DZNE-2020-05944
SP  - 84-88
PY  - 2017
AB  - The use of biomarkers for diagnostics of Alzheimer's disease (AD) has increased over the last years in specialized care and experimental settings. With the possibly upcoming availability of disease-modifying therapeutic agents, the diagnostics and treatment of patients with cognitive impairment will change. Biomarkers will be used as theranostic markers for case finding. The development and evaluation of biomarkers can be framed in a phase model from preclinical studies through trials in expert center settings to the evaluation of biomarkers in primary care, up to testing the efficacy and the impact of biomarkers on the healthcare system. Hippocampal volumetry is the most accepted and in-depth tested biomarker for AD diagnostics and prediction of the course. Therefore, hippocampus volumetry is used to illustrate the phase model of biomarker development and present the milestones already achieved and questions still to be resolved.
KW  - Alzheimer Disease: diagnostic imaging
KW  - Alzheimer Disease: metabolism
KW  - Alzheimer Disease: pathology
KW  - Biomarkers: cerebrospinal fluid
KW  - Brain: diagnostic imaging
KW  - Brain: metabolism
KW  - Brain: pathology
KW  - Health Services Research: organization & administration
KW  - Humans
KW  - Molecular Imaging: methods
KW  - Positron-Emission Tomography: methods
KW  - Reproducibility of Results
KW  - Sensitivity and Specificity
KW  - Translational Medical Research: organization & administration
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:28405748
DO  - DOI:10.1007/s00391-017-1225-3
UR  - https://pub.dzne.de/record/139622
ER  -