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| 001 | 139622 | ||
| 005 | 20250415125852.0 | ||
| 024 | 7 | _ | |a 10.1007/s00391-017-1225-3 |2 doi |
| 024 | 7 | _ | |a pmid:28405748 |2 pmid |
| 024 | 7 | _ | |a 0044-281X |2 ISSN |
| 024 | 7 | _ | |a 0948-6704 |2 ISSN |
| 024 | 7 | _ | |a 1435-1269 |2 ISSN |
| 037 | _ | _ | |a DZNE-2020-05944 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 150 |
| 100 | 1 | _ | |a Kilimann, Ingo |0 P:(DE-2719)2810394 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Translation of imaging biomarkers from clinical research to healthcare. |
| 260 | _ | _ | |a Heidelberg |c 2017 |b Springer Medizin |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2017-04-12 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2017-05-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1744714694_17922 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a The use of biomarkers for diagnostics of Alzheimer's disease (AD) has increased over the last years in specialized care and experimental settings. With the possibly upcoming availability of disease-modifying therapeutic agents, the diagnostics and treatment of patients with cognitive impairment will change. Biomarkers will be used as theranostic markers for case finding. The development and evaluation of biomarkers can be framed in a phase model from preclinical studies through trials in expert center settings to the evaluation of biomarkers in primary care, up to testing the efficacy and the impact of biomarkers on the healthcare system. Hippocampal volumetry is the most accepted and in-depth tested biomarker for AD diagnostics and prediction of the course. Therefore, hippocampus volumetry is used to illustrate the phase model of biomarker development and present the milestones already achieved and questions still to be resolved. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 542 | _ | _ | |i 2017-04-12 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Biomarkers |2 NLM Chemicals |
| 650 | _ | 2 | |a Alzheimer Disease: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: metabolism |2 MeSH |
| 650 | _ | 2 | |a Alzheimer Disease: pathology |2 MeSH |
| 650 | _ | 2 | |a Biomarkers: cerebrospinal fluid |2 MeSH |
| 650 | _ | 2 | |a Brain: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Brain: metabolism |2 MeSH |
| 650 | _ | 2 | |a Brain: pathology |2 MeSH |
| 650 | _ | 2 | |a Health Services Research: organization & administration |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Molecular Imaging: methods |2 MeSH |
| 650 | _ | 2 | |a Positron-Emission Tomography: methods |2 MeSH |
| 650 | _ | 2 | |a Reproducibility of Results |2 MeSH |
| 650 | _ | 2 | |a Sensitivity and Specificity |2 MeSH |
| 650 | _ | 2 | |a Translational Medical Research: organization & administration |2 MeSH |
| 700 | 1 | _ | |a Thyrian, Jochen René |0 P:(DE-2719)2290613 |b 1 |u dzne |
| 700 | 1 | _ | |a Hoffmann, Wolfgang |0 P:(DE-2719)2000040 |b 2 |u dzne |
| 700 | 1 | _ | |a Teipel, Stefan J |0 P:(DE-2719)2000026 |b 3 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1007/s00391-017-1225-3 |b : Springer Science and Business Media LLC, 2017-04-12 |n S2 |p 84-88 |3 journal-article |2 Crossref |t Zeitschrift für Gerontologie und Geriatrie |v 50 |y 2017 |x 0948-6704 |
| 773 | _ | _ | |a 10.1007/s00391-017-1225-3 |g Vol. 50, no. Suppl 2, p. 84 - 88 |0 PERI:(DE-600)1463317-6 |n S2 |q 50:Suppl 2<84 - 88 |p 84-88 |t Zeitschrift für Gerontologie und Geriatrie |v 50 |y 2017 |x 0948-6704 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/139622/files/DZNE-2020-05944_Restricted.pdf |
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| 910 | 1 | _ | |a Deutsches Zentrum für Neurodegenerative Erkrankungen |0 I:(DE-588)1065079516 |k DZNE |b 0 |6 P:(DE-2719)2810394 |
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| 914 | 1 | _ | |y 2017 |
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| 920 | 1 | _ | |0 I:(DE-2719)1510100 |k AG Teipel |l Clinical Dementia Research (Rostock /Greifswald) |x 0 |
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| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.jalz.2011.03.008 |2 Crossref |o 10.1016/j.jalz.2011.03.008 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1067/mcp.2001.113989 |2 Crossref |o 10.1067/mcp.2001.113989 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/BF00692056 |2 Crossref |o 10.1007/BF00692056 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0306-4522(99)00476-5 |2 Crossref |o 10.1016/S0306-4522(99)00476-5 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3233/JAD-2011-0004 |2 Crossref |o 10.3233/JAD-2011-0004 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/BF00308809 |2 Crossref |o 10.1007/BF00308809 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3233/JAD-150063 |2 Crossref |o 10.3233/JAD-150063 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.neurobiolaging.2013.02.002 |2 Crossref |o 10.1016/j.neurobiolaging.2013.02.002 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S0140-6736(89)90911-2 |2 Crossref |o 10.1016/S0140-6736(89)90911-2 |
| 999 | C | 5 | |y 1993 |2 Crossref |o MJ Leon De 1993 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.jalz.2014.05.1756 |2 Crossref |o 10.1016/j.jalz.2014.05.1756 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1007/s00415-010-5650-0 |2 Crossref |o 10.1007/s00415-010-5650-0 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.58.10.1476 |2 Crossref |o 10.1212/WNL.58.10.1476 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.pneurobio.2011.11.008 |2 Crossref |o 10.1016/j.pneurobio.2011.11.008 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.58.5.750 |2 Crossref |o 10.1212/WNL.58.5.750 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1212/WNL.41.1.51 |2 Crossref |o 10.1212/WNL.41.1.51 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.jalz.2011.03.005 |2 Crossref |o 10.1016/j.jalz.2011.03.005 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1080/14728214.2016.1241232 |2 Crossref |o 10.1080/14728214.2016.1241232 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1111/j.1541-0420.2005.00420.x |2 Crossref |o 10.1111/j.1541-0420.2005.00420.x |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/jnci/93.14.1054 |2 Crossref |o 10.1093/jnci/93.14.1054 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.2174/156720509788929273 |2 Crossref |o 10.2174/156720509788929273 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1093/brain/awp007 |2 Crossref |o 10.1093/brain/awp007 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/S1474-4422(15)00093-9 |2 Crossref |o 10.1016/S1474-4422(15)00093-9 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.3233/JAD-160778 |2 Crossref |o 10.3233/JAD-160778 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1186/1745-6215-13-56 |2 Crossref |o 10.1186/1745-6215-13-56 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1002/gps.4126 |2 Crossref |o 10.1002/gps.4126 |
| 999 | C | 5 | |9 -- missing cx lookup -- |a 10.1016/j.jalz.2017.01.009 |2 Crossref |o 10.1016/j.jalz.2017.01.009 |
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