000139641 001__ 139641
000139641 005__ 20240409133042.0
000139641 0247_ $$2doi$$a10.1007/s11682-016-9660-0
000139641 0247_ $$2pmid$$apmid:27917451
000139641 0247_ $$2ISSN$$a1931-7557
000139641 0247_ $$2ISSN$$a1931-7565
000139641 037__ $$aDZNE-2020-05963
000139641 041__ $$aEnglish
000139641 082__ $$a150
000139641 1001_ $$aNickchen, Katharina$$b0
000139641 245__ $$aReversal learning reveals cognitive deficits and altered prediction error encoding in the ventral striatum in Huntington's disease.
000139641 260__ $$aNew York, NY [u.a.]$$bSpringer$$c2017
000139641 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2016-12-05
000139641 264_1 $$2Crossref$$3print$$bSpringer Science and Business Media LLC$$c2017-12-01
000139641 3367_ $$2DRIVER$$aarticle
000139641 3367_ $$2DataCite$$aOutput Types/Journal article
000139641 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1712662180_12208
000139641 3367_ $$2BibTeX$$aARTICLE
000139641 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000139641 3367_ $$00$$2EndNote$$aJournal Article
000139641 520__ $$aHuntington's disease (HD) is an autosomal dominant neurodegenerative condition characterized by a triad of movement disorder, neuropsychiatric symptoms and cognitive deficits. The striatum is particularly vulnerable to the effects of mutant huntingtin, and cell loss can already be found in presymptomatic stages. Since the striatum is well known for its role in reinforcement learning, we hypothesized to find altered behavioral and neural responses in HD patients in a probabilistic reinforcement learning task performed during functional magnetic resonance imaging. We studied 24 HD patients without central nervous system (CNS)-active medication and 25 healthy controls. Twenty HD patients and 24 healthy controls were able to complete the task. Computational modeling was used to calculate prediction error values and estimate individual parameters. We observed that gray matter density and prediction error signals during the learning task were related to disease stage. HD patients in advanced disease stages appear to use a less complex strategy in the reversal learning task. In contrast, HD patients in early disease stages show intact encoding of learning signals in the degenerating left ventral striatum. This effect appears to be lost with disease progression.
000139641 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0
000139641 542__ $$2Crossref$$i2016-12-05$$uhttp://www.springer.com/tdm
000139641 588__ $$aDataset connected to CrossRef, PubMed,
000139641 650_2 $$2MeSH$$aAdult
000139641 650_2 $$2MeSH$$aAlgorithms
000139641 650_2 $$2MeSH$$aBrain Mapping
000139641 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging
000139641 650_2 $$2MeSH$$aCognitive Dysfunction: physiopathology
000139641 650_2 $$2MeSH$$aCohort Studies
000139641 650_2 $$2MeSH$$aComputer Simulation
000139641 650_2 $$2MeSH$$aDisease Progression
000139641 650_2 $$2MeSH$$aFemale
000139641 650_2 $$2MeSH$$aFunctional Laterality
000139641 650_2 $$2MeSH$$aGray Matter: diagnostic imaging
000139641 650_2 $$2MeSH$$aGray Matter: physiopathology
000139641 650_2 $$2MeSH$$aHumans
000139641 650_2 $$2MeSH$$aHuntington Disease: diagnostic imaging
000139641 650_2 $$2MeSH$$aHuntington Disease: genetics
000139641 650_2 $$2MeSH$$aHuntington Disease: physiopathology
000139641 650_2 $$2MeSH$$aHuntington Disease: psychology
000139641 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000139641 650_2 $$2MeSH$$aMale
000139641 650_2 $$2MeSH$$aMiddle Aged
000139641 650_2 $$2MeSH$$aNeuropsychological Tests
000139641 650_2 $$2MeSH$$aProbability Learning
000139641 650_2 $$2MeSH$$aReversal Learning: physiology
000139641 650_2 $$2MeSH$$aVentral Striatum: diagnostic imaging
000139641 650_2 $$2MeSH$$aVentral Striatum: physiopathology
000139641 7001_ $$aBoehme, Rebecca$$b1
000139641 7001_ $$aDel Mar Amador, Maria$$b2
000139641 7001_ $$aHälbig, Thomas D$$b3
000139641 7001_ $$aDehnicke, Katharina$$b4
000139641 7001_ $$aPanneck, Patricia$$b5
000139641 7001_ $$aBehr, Joachim$$b6
000139641 7001_ $$aPrass, Konstantin$$b7
000139641 7001_ $$aHeinz, Andreas$$b8
000139641 7001_ $$aDeserno, Lorenz$$b9
000139641 7001_ $$aSchlagenhauf, Florian$$b10
000139641 7001_ $$0P:(DE-2719)2811122$$aPriller, Josef$$b11$$eLast author$$udzne
000139641 77318 $$2Crossref$$3journal-article$$a10.1007/s11682-016-9660-0$$b : Springer Science and Business Media LLC, 2016-12-05$$n6$$p1862-1872$$tBrain Imaging and Behavior$$v11$$x1931-7557$$y2016
000139641 773__ $$0PERI:(DE-600)2377165-3$$a10.1007/s11682-016-9660-0$$gVol. 11, no. 6, p. 1862 - 1872$$n6$$p1862-1872$$q11:6<1862 - 1872$$tBrain imaging and behavior$$v11$$x1931-7557$$y2017
000139641 8564_ $$uhttps://pub.dzne.de/record/139641/files/DZNE-2020-05963_Restricted.pdf
000139641 8564_ $$uhttps://pub.dzne.de/record/139641/files/DZNE-2020-05963_Restricted.pdf?subformat=pdfa$$xpdfa
000139641 909CO $$ooai:pub.dzne.de:139641$$pVDB
000139641 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811122$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b11$$kDZNE
000139641 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0
000139641 9141_ $$y2017
000139641 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bBRAIN IMAGING BEHAV : 2021$$d2023-03-30
000139641 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-03-30
000139641 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-03-30
000139641 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-03-30
000139641 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-03-30
000139641 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2023-03-30
000139641 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-03-30
000139641 9201_ $$0I:(DE-2719)5000007$$kAG Priller$$lTranslational Neuropsychiatry$$x0
000139641 980__ $$ajournal
000139641 980__ $$aVDB
000139641 980__ $$aI:(DE-2719)5000007
000139641 980__ $$aUNRESTRICTED
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1755-5949.2010.00134.x$$o10.1111/j.1755-5949.2010.00134.x
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2005.02.018$$o10.1016/j.neuroimage.2005.02.018
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1136/jnnp.2010.208264$$o10.1136/jnnp.2010.208264
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.biopsych.2011.07.030$$o10.1016/j.biopsych.2011.07.030
000139641 999C5 $$2Crossref$$oR Barker Oxford textbook of movement disorders 2013$$tOxford textbook of movement disorders$$y2013
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1150605$$o10.1126/science.1150605
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.expneurol.2012.02.003$$o10.1016/j.expneurol.2012.02.003
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2010.04.016$$o10.1016/j.neuron.2010.04.016
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/npp.2009.129$$o10.1038/npp.2009.129
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1001/jamapsychiatry.2014.1093$$o10.1001/jamapsychiatry.2014.1093
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1136/jnnp.2004.047993$$o10.1136/jnnp.2004.047993
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0028-3932(99)00035-4$$o10.1016/S0028-3932(99)00035-4
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1053-8119(03)00169-1$$o10.1016/S1053-8119(03)00169-1
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1371/journal.pone.0114569$$o10.1371/journal.pone.0114569
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.16-05-01936.1996$$o10.1523/JNEUROSCI.16-05-01936.1996
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/mds.21137$$o10.1002/mds.21137
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0896-6273(03)00169-7$$o10.1016/S0896-6273(03)00169-7
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuron.2012.10.017$$o10.1016/j.neuron.2012.10.017
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/ana.22105$$o10.1002/ana.22105
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuropsychologia.2007.12.002$$o10.1016/j.neuropsychologia.2007.12.002
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2013.11.034$$o10.1016/j.neuroimage.2013.11.034
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.275.5306.1593$$o10.1126/science.275.5306.1593
000139641 999C5 $$2Crossref$$oR Sutton Reinforcement learning: an introduction 1998$$tReinforcement learning: an introduction$$y1998
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/brain/awf179$$o10.1093/brain/awf179
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/s1474-4422(11)70070-9$$o10.1016/s1474-4422(11)70070-9
000139641 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1176/appi.ajp.163.9.1603$$o10.1176/appi.ajp.163.9.1603