TY  - JOUR
AU  - Nickchen, Katharina
AU  - Boehme, Rebecca
AU  - Del Mar Amador, Maria
AU  - Hälbig, Thomas D
AU  - Dehnicke, Katharina
AU  - Panneck, Patricia
AU  - Behr, Joachim
AU  - Prass, Konstantin
AU  - Heinz, Andreas
AU  - Deserno, Lorenz
AU  - Schlagenhauf, Florian
AU  - Priller, Josef
TI  - Reversal learning reveals cognitive deficits and altered prediction error encoding in the ventral striatum in Huntington's disease.
JO  - Brain imaging and behavior
VL  - 11
IS  - 6
SN  - 1931-7557
CY  - New York, NY [u.a.]
PB  - Springer
M1  - DZNE-2020-05963
SP  - 1862-1872
PY  - 2017
AB  - Huntington's disease (HD) is an autosomal dominant neurodegenerative condition characterized by a triad of movement disorder, neuropsychiatric symptoms and cognitive deficits. The striatum is particularly vulnerable to the effects of mutant huntingtin, and cell loss can already be found in presymptomatic stages. Since the striatum is well known for its role in reinforcement learning, we hypothesized to find altered behavioral and neural responses in HD patients in a probabilistic reinforcement learning task performed during functional magnetic resonance imaging. We studied 24 HD patients without central nervous system (CNS)-active medication and 25 healthy controls. Twenty HD patients and 24 healthy controls were able to complete the task. Computational modeling was used to calculate prediction error values and estimate individual parameters. We observed that gray matter density and prediction error signals during the learning task were related to disease stage. HD patients in advanced disease stages appear to use a less complex strategy in the reversal learning task. In contrast, HD patients in early disease stages show intact encoding of learning signals in the degenerating left ventral striatum. This effect appears to be lost with disease progression.
KW  - Adult
KW  - Algorithms
KW  - Brain Mapping
KW  - Cognitive Dysfunction: diagnostic imaging
KW  - Cognitive Dysfunction: physiopathology
KW  - Cohort Studies
KW  - Computer Simulation
KW  - Disease Progression
KW  - Female
KW  - Functional Laterality
KW  - Gray Matter: diagnostic imaging
KW  - Gray Matter: physiopathology
KW  - Humans
KW  - Huntington Disease: diagnostic imaging
KW  - Huntington Disease: genetics
KW  - Huntington Disease: physiopathology
KW  - Huntington Disease: psychology
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Neuropsychological Tests
KW  - Probability Learning
KW  - Reversal Learning: physiology
KW  - Ventral Striatum: diagnostic imaging
KW  - Ventral Striatum: physiopathology
LB  - PUB:(DE-HGF)16
C6  - pmid:27917451
DO  - DOI:10.1007/s11682-016-9660-0
UR  - https://pub.dzne.de/record/139641
ER  -