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| Home > Publications Database > Reversal learning reveals cognitive deficits and altered prediction error encoding in the ventral striatum in Huntington's disease. > print |
| 001 | 139641 | ||
| 005 | 20240409133042.0 | ||
| 024 | 7 | _ | |a 10.1007/s11682-016-9660-0 |2 doi |
| 024 | 7 | _ | |a pmid:27917451 |2 pmid |
| 024 | 7 | _ | |a 1931-7557 |2 ISSN |
| 024 | 7 | _ | |a 1931-7565 |2 ISSN |
| 037 | _ | _ | |a DZNE-2020-05963 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 150 |
| 100 | 1 | _ | |a Nickchen, Katharina |b 0 |
| 245 | _ | _ | |a Reversal learning reveals cognitive deficits and altered prediction error encoding in the ventral striatum in Huntington's disease. |
| 260 | _ | _ | |a New York, NY [u.a.] |c 2017 |b Springer |
| 264 | _ | 1 | |3 online |2 Crossref |b Springer Science and Business Media LLC |c 2016-12-05 |
| 264 | _ | 1 | |3 print |2 Crossref |b Springer Science and Business Media LLC |c 2017-12-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1712662180_12208 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Huntington's disease (HD) is an autosomal dominant neurodegenerative condition characterized by a triad of movement disorder, neuropsychiatric symptoms and cognitive deficits. The striatum is particularly vulnerable to the effects of mutant huntingtin, and cell loss can already be found in presymptomatic stages. Since the striatum is well known for its role in reinforcement learning, we hypothesized to find altered behavioral and neural responses in HD patients in a probabilistic reinforcement learning task performed during functional magnetic resonance imaging. We studied 24 HD patients without central nervous system (CNS)-active medication and 25 healthy controls. Twenty HD patients and 24 healthy controls were able to complete the task. Computational modeling was used to calculate prediction error values and estimate individual parameters. We observed that gray matter density and prediction error signals during the learning task were related to disease stage. HD patients in advanced disease stages appear to use a less complex strategy in the reversal learning task. In contrast, HD patients in early disease stages show intact encoding of learning signals in the degenerating left ventral striatum. This effect appears to be lost with disease progression. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 542 | _ | _ | |i 2016-12-05 |2 Crossref |u http://www.springer.com/tdm |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Algorithms |2 MeSH |
| 650 | _ | 2 | |a Brain Mapping |2 MeSH |
| 650 | _ | 2 | |a Cognitive Dysfunction: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Cognitive Dysfunction: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Cohort Studies |2 MeSH |
| 650 | _ | 2 | |a Computer Simulation |2 MeSH |
| 650 | _ | 2 | |a Disease Progression |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Functional Laterality |2 MeSH |
| 650 | _ | 2 | |a Gray Matter: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Gray Matter: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Huntington Disease: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Huntington Disease: genetics |2 MeSH |
| 650 | _ | 2 | |a Huntington Disease: physiopathology |2 MeSH |
| 650 | _ | 2 | |a Huntington Disease: psychology |2 MeSH |
| 650 | _ | 2 | |a Magnetic Resonance Imaging |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Middle Aged |2 MeSH |
| 650 | _ | 2 | |a Neuropsychological Tests |2 MeSH |
| 650 | _ | 2 | |a Probability Learning |2 MeSH |
| 650 | _ | 2 | |a Reversal Learning: physiology |2 MeSH |
| 650 | _ | 2 | |a Ventral Striatum: diagnostic imaging |2 MeSH |
| 650 | _ | 2 | |a Ventral Striatum: physiopathology |2 MeSH |
| 700 | 1 | _ | |a Boehme, Rebecca |b 1 |
| 700 | 1 | _ | |a Del Mar Amador, Maria |b 2 |
| 700 | 1 | _ | |a Hälbig, Thomas D |b 3 |
| 700 | 1 | _ | |a Dehnicke, Katharina |b 4 |
| 700 | 1 | _ | |a Panneck, Patricia |b 5 |
| 700 | 1 | _ | |a Behr, Joachim |b 6 |
| 700 | 1 | _ | |a Prass, Konstantin |b 7 |
| 700 | 1 | _ | |a Heinz, Andreas |b 8 |
| 700 | 1 | _ | |a Deserno, Lorenz |b 9 |
| 700 | 1 | _ | |a Schlagenhauf, Florian |b 10 |
| 700 | 1 | _ | |a Priller, Josef |0 P:(DE-2719)2811122 |b 11 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1007/s11682-016-9660-0 |b : Springer Science and Business Media LLC, 2016-12-05 |n 6 |p 1862-1872 |3 journal-article |2 Crossref |t Brain Imaging and Behavior |v 11 |y 2016 |x 1931-7557 |
| 773 | _ | _ | |a 10.1007/s11682-016-9660-0 |g Vol. 11, no. 6, p. 1862 - 1872 |0 PERI:(DE-600)2377165-3 |n 6 |q 11:6<1862 - 1872 |p 1862-1872 |t Brain imaging and behavior |v 11 |y 2017 |x 1931-7557 |
| 856 | 4 | _ | |u https://pub.dzne.de/record/139641/files/DZNE-2020-05963_Restricted.pdf |
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