%0 Journal Article
%A Grothe, Michel J
%A Barthel, Henryk
%A Sepulcre, Jorge
%A Dyrba, Martin
%A Sabri, Osama
%A Teipel, Stefan J
%A Initiative, Alzheimer's Disease Neuroimaging
%A Weiner, Michael
%A Aisen, Paul
%A Weiner, Michael
%A Aisen, Paul
%A Petersen, Ronald
%A Jack, Clifford R
%A Jagust, William
%A Trojanowki, John Q
%A Toga, Arthur W
%A Beckett, Laurel
%A Green, Robert C
%A Saykin, Andrew J
%A Morris, John
%A Liu, Enchi
%A Green, Robert C
%A Montine, Tom
%A Petersen, Ronald
%A Aisen, Paul
%A Gamst, Anthony
%A Thomas, Ronald G
%A Donohue, Michael
%A Walter, Sarah
%A Gessert, Devon
%A Sather, Tamie
%A Beckett, Laurel
%A Harvey, Danielle
%A Gamst, Anthony
%A Donohue, Michael
%A Kornak, John
%A Jack, Clifford R
%A Dale, Anders
%A Bernstein, Matthew
%A Felmlee, Joel
%A Fox, Nick
%A Thompson, Paul
%A Schuff, Norbert
%A Alexander, Gene
%A DeCarli, Charles
%A Jagust, William
%A Bandy, Dan
%A Koeppe, Robert A
%A Foster, Norm
%A Reiman, Eric M
%A Chen, Kewei
%A Mathis, Chet
%A Morris, John
%A Cairns, Nigel J
%A Taylor-Reinwald, Lisa
%A Trojanowki, J. Q.
%A Shaw, Les
%A Lee, Virginia M Y
%A Korecka, Magdalena
%A Toga, Arthur W
%A Crawford, Karen
%A Neu, Scott
%A Saykin, Andrew J
%A Foroud, Tatiana M
%A Potkin, Steven
%A Shen, Li
%A Kachaturian, Zaven
%A Frank, Richard
%A Snyder, Peter J
%A Molchan, Susan
%A Kaye, Jeffrey
%A Quinn, Joseph
%A Lind, Betty
%A Dolen, Sara
%A Schneider, Lon S
%A Pawluczyk, Sonia
%A Spann, Bryan M
%A Brewer, James
%A Vanderswag, Helen
%A Heidebrink, Judith L
%A Lord, Joanne L
%A Petersen, Ronald
%A Johnson, Kris
%A Doody, Rachelle S
%A Villanueva-Meyer, Javier
%A Chowdhury, Munir
%A Stern, Yaakov
%A Honig, Lawrence S
%A Bell, Karen L
%A Morris, John C
%A Ances, Beau
%A Carroll, Maria
%A Leon, Sue
%A Mintun, Mark A
%A Schneider, Stacy
%A Marson, Daniel
%A Griffith, Randall
%A Clark, David
%A Grossman, Hillel
%A Mitsis, Effie
%A Romirowsky, Aliza
%A deToledo-Morrell, Leyla
%A Shah, Raj C
%A Duara, Ranjan
%A Varon, Daniel
%A Roberts, Peggy
%A Albert, Marilyn
%A Onyike, Chiadi
%A Kielb, Stephanie
%A Rusinek, Henry
%A de Leon, Mony J
%A Glodzik, Lidia
%A De Santi, Susan
%A Doraiswamy, P Murali
%A Petrella, Jeffrey R
%A Coleman, R Edward
%A Arnold, Steven E
%A Karlawish, Jason H
%A Wolk, David
%A Smith, Charles D
%A Jicha, Greg
%A Hardy, Peter
%A Lopez, Oscar L
%A Oakley, MaryAnn
%A Simpson, Donna M
%A Porsteinsson, Anton P
%A Goldstein, Bonnie S
%A Martin, Kim
%A Makino, Kelly M
%A Ismail, M Saleem
%A Brand, Connie
%A Mulnard, Ruth A
%A Thai, Gaby
%A Mc-Adams-Ortiz, Catherine
%A Womack, Kyle
%A Mathews, Dana
%A Quiceno, Mary
%A Diaz-Arrastia, Ramon
%A King, Richard
%A Weiner, Myron
%A Martin-Cook, Kristen
%A DeVous, Michael
%A Levey, Allan I
%A Lah, James J
%A Cellar, Janet S
%A Burns, Jeffrey M
%A Anderson, Heather S
%A Swerdlow, Russell H
%A Apostolova, Liana
%A Lu, Po H
%A Bartzokis, George
%A Silverman, Daniel H S
%A Parfitt, Francine
%A Johnson, Heather
%A Farlow, Martin R
%A Hake, Ann Marie
%A Matthews, Brandy R
%A Herring, Scott
%A van Dyck, Christopher H
%A Carson, Richard E
%A MacAvoy, Martha G
%A Chertkow, Howard
%A Bergman, Howard
%A Hosein, Chris
%A Black, Sandra
%A Stefanovic, Bojana
%A Caldwell, Curtis
%A Robin Hsiung, Ging-Yuek
%A Feldman, Howard
%A Mudge, Benita
%A Assaly, Michele
%A Kertesz, Andrew
%A Rogers, John
%A Trost, Dick
%A Bernick, Charles
%A Munic, Donna
%A Kerwin, Diana
%A Mesulam, Marek-Marsel
%A Lipowski, Kristina
%A Wu, Chuang-Kuo
%A Johnson, Nancy
%A Sadowsky, Carl
%A Martinez, Walter
%A Villena, Teresa
%A Turner, Raymond Scott
%A Johnson, Kathleen
%A Reynolds, Brigid
%A Sperling, Reisa A
%A Johnson, Keith A
%A Marshall, Gad
%A Frey, Meghan
%A Yesavage, Jerome
%A Taylor, Joy L
%A Lane, Barton
%A Rosen, Allyson
%A Tinklenberg, Jared
%A Sabbagh, Marwan
%A Belden, Christine
%A Jacobson, Sandra
%A Kowall, Neil
%A Killiany, Ronald
%A Budson, Andrew E
%A Norbash, Alexander
%A Johnson, Patricia Lynn
%A Obisesan, Thomas O
%A Wolday, Saba
%A Bwayo, Salome K
%A Lerner, Alan
%A Hudson, Leon
%A Ogrocki, Paula
%A Fletcher, Evan
%A Carmichael, Owen
%A Olichney, John
%A DeCarli, Charles
%A Kittur, Smita
%A Borrie, Michael
%A Lee, T-Y
%A Bartha, Rob
%A Johnson, Sterling
%A Asthana, Sanjay
%A Carlsson, Cynthia M
%A Potkin, Steven G
%A Preda, Adrian
%A Nguyen, Dana
%A Tariot, Pierre
%A Fleisher, Adam
%A Reeder, Stephanie
%A Bates, Vernice
%A Capote, Horacio
%A Rainka, Michelle
%A Scharre, Douglas W
%A Kataki, Maria
%A Zimmerman, Earl A
%A Celmins, Dzintra
%A Brown, Alice D
%A Pearlson, Godfrey D
%A Blank, Karen
%A Anderson, Karen
%A Saykin, Andrew J
%A Santulli, Robert B
%A Schwartz, Eben S
%A Sink, Kaycee M
%A Williamson, Jeff D
%A Garg, Pradeep
%A Watkins, Franklin
%A Ott, Brian R
%A Querfurth, Henry
%A Tremont, Geoffrey
%A Salloway, Stephen
%A Malloy, Paul
%A Correia, Stephen
%A Rosen, Howard J
%A Miller, Bruce L
%A Mintzer, Jacobo
%A Longmire, Crystal Flynn
%A Spicer, Kenneth
%A Finger, Elizabether
%A Rachinsky, Irina
%A Rogers, John
%A Kertesz, Andrew
%A Drost, Dick
%A Pomara, Nunzio
%A Hernando, Raymundo
%A Sarrael, Antero
%A Schultz, Susan K
%A Boles Ponto, Laura L
%A Shim, Hyungsub
%A Smith, Karen Elizabeth
%A Relkin, Norman
%A Chaing, Gloria
%A Raudin, Lisa
%A Smith, Amanda
%A Fargher, Kristin
%A Raj, Balebail Ashok
%T In vivo staging of regional amyloid deposition.
%J Neurology
%V 89
%N 20
%@ 0028-3878
%C [S.l.]
%I Ovid
%M DZNE-2020-05988
%P 2031-2038
%D 2017
%X To estimate a regional progression pattern of amyloid deposition from cross-sectional amyloid-sensitive PET data and evaluate its potential for in vivo staging of an individual's amyloid pathology.Multiregional analysis of florbetapir (18F-AV45)-PET data was used to determine individual amyloid distribution profiles in a sample of 667 participants from the Alzheimer's Disease Neuroimaging Initiative cohort, including cognitively normal older individuals (CN) as well as patients with mild cognitive impairment and Alzheimer disease (AD) dementia. The frequency of regional amyloid positivity across CN individuals was used to construct a 4-stage model of progressing amyloid pathology, and individual distribution profiles were used to evaluate the consistency of this hierarchical stage model across the full cohort.According to a 4-stage model, amyloid deposition begins in temporobasal and frontomedial areas, and successively affects the remaining associative neocortex, primary sensory-motor areas and the medial temporal lobe, and finally the striatum. Amyloid deposition in these brain regions showed a highly consistent hierarchical nesting across participants, where only 2
%K Aged
%K Aged, 80 and over
%K Aging: metabolism
%K Alzheimer Disease: diagnostic imaging
%K Alzheimer Disease: metabolism
%K Amyloid beta-Peptides: cerebrospinal fluid
%K Amyloid beta-Peptides: metabolism
%K Aniline Compounds
%K Biomarkers: metabolism
%K Cerebral Cortex: diagnostic imaging
%K Cerebral Cortex: metabolism
%K Cognitive Dysfunction: diagnostic imaging
%K Cognitive Dysfunction: metabolism
%K Cross-Sectional Studies
%K Disease Progression
%K Ethylene Glycols
%K Female
%K Humans
%K Male
%K Neostriatum: diagnostic imaging
%K Neostriatum: metabolism
%K Peptide Fragments: cerebrospinal fluid
%K Positron-Emission Tomography: methods
%K Amyloid beta-Peptides (NLM Chemicals)
%K Aniline Compounds (NLM Chemicals)
%K Biomarkers (NLM Chemicals)
%K Ethylene Glycols (NLM Chemicals)
%K Peptide Fragments (NLM Chemicals)
%K amyloid beta-protein (1-42) (NLM Chemicals)
%K florbetapir (NLM Chemicals)
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:29046362
%2 pmc:PMC5711511
%R 10.1212/WNL.0000000000004643
%U https://pub.dzne.de/record/139666