000139666 001__ 139666 000139666 005__ 20240321220648.0 000139666 0247_ $$2doi$$a10.1212/WNL.0000000000004643 000139666 0247_ $$2pmid$$apmid:29046362 000139666 0247_ $$2pmc$$apmc:PMC5711511 000139666 0247_ $$2ISSN$$a0028-3878 000139666 0247_ $$2ISSN$$a1526-632X 000139666 0247_ $$2altmetric$$aaltmetric:27623296 000139666 037__ $$aDZNE-2020-05988 000139666 041__ $$aEnglish 000139666 082__ $$a610 000139666 1001_ $$0P:(DE-2719)2810708$$aGrothe, Michel J$$b0$$eFirst author$$udzne 000139666 245__ $$aIn vivo staging of regional amyloid deposition. 000139666 260__ $$a[S.l.]$$bOvid$$c2017 000139666 264_1 $$2Crossref$$3online$$bOvid Technologies (Wolters Kluwer Health)$$c2017-10-18 000139666 264_1 $$2Crossref$$3print$$bOvid Technologies (Wolters Kluwer Health)$$c2017-11-14 000139666 3367_ $$2DRIVER$$aarticle 000139666 3367_ $$2DataCite$$aOutput Types/Journal article 000139666 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1592481273_24921 000139666 3367_ $$2BibTeX$$aARTICLE 000139666 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000139666 3367_ $$00$$2EndNote$$aJournal Article 000139666 520__ $$aTo estimate a regional progression pattern of amyloid deposition from cross-sectional amyloid-sensitive PET data and evaluate its potential for in vivo staging of an individual's amyloid pathology.Multiregional analysis of florbetapir (18F-AV45)-PET data was used to determine individual amyloid distribution profiles in a sample of 667 participants from the Alzheimer's Disease Neuroimaging Initiative cohort, including cognitively normal older individuals (CN) as well as patients with mild cognitive impairment and Alzheimer disease (AD) dementia. The frequency of regional amyloid positivity across CN individuals was used to construct a 4-stage model of progressing amyloid pathology, and individual distribution profiles were used to evaluate the consistency of this hierarchical stage model across the full cohort.According to a 4-stage model, amyloid deposition begins in temporobasal and frontomedial areas, and successively affects the remaining associative neocortex, primary sensory-motor areas and the medial temporal lobe, and finally the striatum. Amyloid deposition in these brain regions showed a highly consistent hierarchical nesting across participants, where only 2% exhibited distribution profiles that deviated from the staging scheme. The earliest in vivo amyloid stages were mostly missed by conventional dichotomous classification approaches based on global florbetapir-PET signal, but were associated with significantly reduced CSF Aβ42 levels. Advanced in vivo amyloid stages were most frequent in patients with AD and correlated with cognitive impairment in individuals without dementia.The highly consistent regional hierarchy of PET-evidenced amyloid deposition across participants resembles neuropathologic observations and suggests a predictable regional sequence that may be used to stage an individual's progress of amyloid pathology in vivo. 000139666 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x0 000139666 588__ $$aDataset connected to CrossRef, PubMed, 000139666 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides 000139666 650_7 $$2NLM Chemicals$$aAniline Compounds 000139666 650_7 $$2NLM Chemicals$$aBiomarkers 000139666 650_7 $$2NLM Chemicals$$aEthylene Glycols 000139666 650_7 $$2NLM Chemicals$$aPeptide Fragments 000139666 650_7 $$2NLM Chemicals$$aamyloid beta-protein (1-42) 000139666 650_7 $$06867Q6IKOD$$2NLM Chemicals$$aflorbetapir 000139666 650_2 $$2MeSH$$aAged 000139666 650_2 $$2MeSH$$aAged, 80 and over 000139666 650_2 $$2MeSH$$aAging: metabolism 000139666 650_2 $$2MeSH$$aAlzheimer Disease: diagnostic imaging 000139666 650_2 $$2MeSH$$aAlzheimer Disease: metabolism 000139666 650_2 $$2MeSH$$aAmyloid beta-Peptides: cerebrospinal fluid 000139666 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism 000139666 650_2 $$2MeSH$$aAniline Compounds 000139666 650_2 $$2MeSH$$aBiomarkers: metabolism 000139666 650_2 $$2MeSH$$aCerebral Cortex: diagnostic imaging 000139666 650_2 $$2MeSH$$aCerebral Cortex: metabolism 000139666 650_2 $$2MeSH$$aCognitive Dysfunction: diagnostic imaging 000139666 650_2 $$2MeSH$$aCognitive Dysfunction: metabolism 000139666 650_2 $$2MeSH$$aCross-Sectional Studies 000139666 650_2 $$2MeSH$$aDisease Progression 000139666 650_2 $$2MeSH$$aEthylene Glycols 000139666 650_2 $$2MeSH$$aFemale 000139666 650_2 $$2MeSH$$aHumans 000139666 650_2 $$2MeSH$$aMale 000139666 650_2 $$2MeSH$$aNeostriatum: diagnostic imaging 000139666 650_2 $$2MeSH$$aNeostriatum: metabolism 000139666 650_2 $$2MeSH$$aPeptide Fragments: cerebrospinal fluid 000139666 650_2 $$2MeSH$$aPositron-Emission Tomography: methods 000139666 7001_ $$aBarthel, Henryk$$b1 000139666 7001_ $$aSepulcre, Jorge$$b2 000139666 7001_ $$0P:(DE-2719)2810283$$aDyrba, Martin$$b3$$udzne 000139666 7001_ $$aSabri, Osama$$b4 000139666 7001_ $$0P:(DE-2719)2000026$$aTeipel, Stefan J$$b5$$eLast author$$udzne 000139666 7001_ $$aInitiative, Alzheimer's Disease Neuroimaging$$b6 000139666 7001_ $$aWeiner, Michael$$b7 000139666 7001_ $$aAisen, Paul$$b8 000139666 7001_ $$aWeiner, Michael$$b9 000139666 7001_ $$aAisen, Paul$$b10 000139666 7001_ $$aPetersen, Ronald$$b11 000139666 7001_ $$aJack, Clifford R$$b12 000139666 7001_ $$aJagust, William$$b13 000139666 7001_ $$aTrojanowki, John Q$$b14 000139666 7001_ $$aToga, Arthur W$$b15 000139666 7001_ $$aBeckett, Laurel$$b16 000139666 7001_ $$aGreen, Robert C$$b17 000139666 7001_ $$aSaykin, Andrew J$$b18 000139666 7001_ $$aMorris, John$$b19 000139666 7001_ $$aLiu, Enchi$$b20 000139666 7001_ $$aGreen, Robert C$$b21 000139666 7001_ $$aMontine, Tom$$b22 000139666 7001_ $$aPetersen, Ronald$$b23 000139666 7001_ $$aAisen, Paul$$b24 000139666 7001_ $$aGamst, Anthony$$b25 000139666 7001_ $$aThomas, Ronald G$$b26 000139666 7001_ $$aDonohue, Michael$$b27 000139666 7001_ $$aWalter, Sarah$$b28 000139666 7001_ $$aGessert, Devon$$b29 000139666 7001_ $$aSather, Tamie$$b30 000139666 7001_ $$aBeckett, Laurel$$b31 000139666 7001_ $$aHarvey, Danielle$$b32 000139666 7001_ $$aGamst, Anthony$$b33 000139666 7001_ $$aDonohue, Michael$$b34 000139666 7001_ $$aKornak, John$$b35 000139666 7001_ $$aJack, Clifford R$$b36 000139666 7001_ $$aDale, Anders$$b37 000139666 7001_ $$aBernstein, Matthew$$b38 000139666 7001_ $$aFelmlee, Joel$$b39 000139666 7001_ $$aFox, Nick$$b40 000139666 7001_ $$aThompson, Paul$$b41 000139666 7001_ $$aSchuff, Norbert$$b42 000139666 7001_ $$aAlexander, Gene$$b43 000139666 7001_ $$aDeCarli, Charles$$b44 000139666 7001_ $$aJagust, William$$b45 000139666 7001_ $$aBandy, Dan$$b46 000139666 7001_ $$aKoeppe, Robert A$$b47 000139666 7001_ $$aFoster, Norm$$b48 000139666 7001_ $$aReiman, Eric M$$b49 000139666 7001_ $$aChen, Kewei$$b50 000139666 7001_ $$aMathis, Chet$$b51 000139666 7001_ $$aMorris, John$$b52 000139666 7001_ $$aCairns, Nigel J$$b53 000139666 7001_ $$aTaylor-Reinwald, Lisa$$b54 000139666 7001_ $$aTrojanowki, J. Q.$$b55 000139666 7001_ $$0P:(DE-HGF)0$$aShaw, Les$$b56 000139666 7001_ $$aLee, Virginia M Y$$b57 000139666 7001_ $$aKorecka, Magdalena$$b58 000139666 7001_ $$aToga, Arthur W$$b59 000139666 7001_ $$aCrawford, Karen$$b60 000139666 7001_ $$aNeu, Scott$$b61 000139666 7001_ $$aSaykin, Andrew J$$b62 000139666 7001_ $$aForoud, Tatiana M$$b63 000139666 7001_ $$aPotkin, Steven$$b64 000139666 7001_ $$aShen, Li$$b65 000139666 7001_ $$aKachaturian, Zaven$$b66 000139666 7001_ $$aFrank, Richard$$b67 000139666 7001_ $$aSnyder, Peter J$$b68 000139666 7001_ $$aMolchan, Susan$$b69 000139666 7001_ $$aKaye, Jeffrey$$b70 000139666 7001_ $$aQuinn, Joseph$$b71 000139666 7001_ $$aLind, Betty$$b72 000139666 7001_ $$aDolen, Sara$$b73 000139666 7001_ $$aSchneider, Lon S$$b74 000139666 7001_ $$aPawluczyk, Sonia$$b75 000139666 7001_ $$aSpann, Bryan M$$b76 000139666 7001_ $$aBrewer, James$$b77 000139666 7001_ $$aVanderswag, Helen$$b78 000139666 7001_ $$aHeidebrink, Judith L$$b79 000139666 7001_ $$aLord, Joanne L$$b80 000139666 7001_ $$aPetersen, Ronald$$b81 000139666 7001_ $$aJohnson, Kris$$b82 000139666 7001_ $$aDoody, Rachelle S$$b83 000139666 7001_ $$aVillanueva-Meyer, Javier$$b84 000139666 7001_ $$aChowdhury, Munir$$b85 000139666 7001_ $$aStern, Yaakov$$b86 000139666 7001_ $$aHonig, Lawrence S$$b87 000139666 7001_ $$aBell, Karen L$$b88 000139666 7001_ $$aMorris, John C$$b89 000139666 7001_ $$aAnces, Beau$$b90 000139666 7001_ $$aCarroll, Maria$$b91 000139666 7001_ $$aLeon, Sue$$b92 000139666 7001_ $$aMintun, Mark A$$b93 000139666 7001_ $$aSchneider, Stacy$$b94 000139666 7001_ $$aMarson, Daniel$$b95 000139666 7001_ $$aGriffith, Randall$$b96 000139666 7001_ $$aClark, David$$b97 000139666 7001_ $$aGrossman, Hillel$$b98 000139666 7001_ $$aMitsis, Effie$$b99 000139666 7001_ $$aRomirowsky, Aliza$$b100 000139666 7001_ $$adeToledo-Morrell, Leyla$$b101 000139666 7001_ $$aShah, Raj C$$b102 000139666 7001_ $$aDuara, Ranjan$$b103 000139666 7001_ $$aVaron, Daniel$$b104 000139666 7001_ $$aRoberts, Peggy$$b105 000139666 7001_ $$aAlbert, Marilyn$$b106 000139666 7001_ $$aOnyike, Chiadi$$b107 000139666 7001_ $$aKielb, Stephanie$$b108 000139666 7001_ $$aRusinek, Henry$$b109 000139666 7001_ $$ade Leon, Mony J$$b110 000139666 7001_ $$aGlodzik, Lidia$$b111 000139666 7001_ $$aDe Santi, Susan$$b112 000139666 7001_ $$aDoraiswamy, P Murali$$b113 000139666 7001_ $$aPetrella, Jeffrey R$$b114 000139666 7001_ $$aColeman, R Edward$$b115 000139666 7001_ $$aArnold, Steven E$$b116 000139666 7001_ $$aKarlawish, Jason H$$b117 000139666 7001_ $$aWolk, David$$b118 000139666 7001_ $$aSmith, Charles D$$b119 000139666 7001_ $$aJicha, Greg$$b120 000139666 7001_ $$aHardy, Peter$$b121 000139666 7001_ $$aLopez, Oscar L$$b122 000139666 7001_ $$aOakley, MaryAnn$$b123 000139666 7001_ $$aSimpson, Donna M$$b124 000139666 7001_ $$aPorsteinsson, Anton P$$b125 000139666 7001_ $$aGoldstein, Bonnie S$$b126 000139666 7001_ $$aMartin, Kim$$b127 000139666 7001_ $$aMakino, Kelly M$$b128 000139666 7001_ $$0P:(DE-HGF)0$$aIsmail, M Saleem$$b129 000139666 7001_ $$aBrand, Connie$$b130 000139666 7001_ $$aMulnard, Ruth A$$b131 000139666 7001_ $$aThai, Gaby$$b132 000139666 7001_ $$aMc-Adams-Ortiz, Catherine$$b133 000139666 7001_ $$aWomack, Kyle$$b134 000139666 7001_ $$aMathews, Dana$$b135 000139666 7001_ $$aQuiceno, Mary$$b136 000139666 7001_ $$aDiaz-Arrastia, Ramon$$b137 000139666 7001_ $$aKing, Richard$$b138 000139666 7001_ $$aWeiner, Myron$$b139 000139666 7001_ $$aMartin-Cook, Kristen$$b140 000139666 7001_ $$aDeVous, Michael$$b141 000139666 7001_ $$aLevey, Allan I$$b142 000139666 7001_ $$aLah, James J$$b143 000139666 7001_ $$aCellar, Janet S$$b144 000139666 7001_ $$aBurns, Jeffrey M$$b145 000139666 7001_ $$aAnderson, Heather S$$b146 000139666 7001_ $$aSwerdlow, Russell H$$b147 000139666 7001_ $$aApostolova, Liana$$b148 000139666 7001_ $$aLu, Po H$$b149 000139666 7001_ $$aBartzokis, George$$b150 000139666 7001_ $$aSilverman, Daniel H S$$b151 000139666 7001_ $$aParfitt, Francine$$b152 000139666 7001_ $$aJohnson, Heather$$b153 000139666 7001_ $$aFarlow, Martin R$$b154 000139666 7001_ $$aHake, Ann Marie$$b155 000139666 7001_ $$aMatthews, Brandy R$$b156 000139666 7001_ $$aHerring, Scott$$b157 000139666 7001_ $$avan Dyck, Christopher H$$b158 000139666 7001_ $$aCarson, Richard E$$b159 000139666 7001_ $$aMacAvoy, Martha G$$b160 000139666 7001_ $$aChertkow, Howard$$b161 000139666 7001_ $$aBergman, Howard$$b162 000139666 7001_ $$aHosein, Chris$$b163 000139666 7001_ $$aBlack, Sandra$$b164 000139666 7001_ $$aStefanovic, Bojana$$b165 000139666 7001_ $$aCaldwell, Curtis$$b166 000139666 7001_ $$aRobin Hsiung, Ging-Yuek$$b167 000139666 7001_ $$aFeldman, Howard$$b168 000139666 7001_ $$aMudge, Benita$$b169 000139666 7001_ $$aAssaly, Michele$$b170 000139666 7001_ $$aKertesz, Andrew$$b171 000139666 7001_ $$aRogers, John$$b172 000139666 7001_ $$aTrost, Dick$$b173 000139666 7001_ $$aBernick, Charles$$b174 000139666 7001_ $$aMunic, Donna$$b175 000139666 7001_ $$aKerwin, Diana$$b176 000139666 7001_ $$aMesulam, Marek-Marsel$$b177 000139666 7001_ $$aLipowski, Kristina$$b178 000139666 7001_ $$aWu, Chuang-Kuo$$b179 000139666 7001_ $$aJohnson, Nancy$$b180 000139666 7001_ $$aSadowsky, Carl$$b181 000139666 7001_ $$aMartinez, Walter$$b182 000139666 7001_ $$aVillena, Teresa$$b183 000139666 7001_ $$aTurner, Raymond Scott$$b184 000139666 7001_ $$aJohnson, Kathleen$$b185 000139666 7001_ $$aReynolds, Brigid$$b186 000139666 7001_ $$aSperling, Reisa A$$b187 000139666 7001_ $$aJohnson, Keith A$$b188 000139666 7001_ $$aMarshall, Gad$$b189 000139666 7001_ $$aFrey, Meghan$$b190 000139666 7001_ $$aYesavage, Jerome$$b191 000139666 7001_ $$aTaylor, Joy L$$b192 000139666 7001_ $$aLane, Barton$$b193 000139666 7001_ $$aRosen, Allyson$$b194 000139666 7001_ $$aTinklenberg, Jared$$b195 000139666 7001_ $$aSabbagh, Marwan$$b196 000139666 7001_ $$aBelden, Christine$$b197 000139666 7001_ $$aJacobson, Sandra$$b198 000139666 7001_ $$aKowall, Neil$$b199 000139666 7001_ $$aKilliany, Ronald$$b200 000139666 7001_ $$aBudson, Andrew E$$b201 000139666 7001_ $$aNorbash, Alexander$$b202 000139666 7001_ $$aJohnson, Patricia Lynn$$b203 000139666 7001_ $$aObisesan, Thomas O$$b204 000139666 7001_ $$aWolday, Saba$$b205 000139666 7001_ $$aBwayo, Salome K$$b206 000139666 7001_ $$aLerner, Alan$$b207 000139666 7001_ $$aHudson, Leon$$b208 000139666 7001_ $$aOgrocki, Paula$$b209 000139666 7001_ $$aFletcher, Evan$$b210 000139666 7001_ $$aCarmichael, Owen$$b211 000139666 7001_ $$aOlichney, John$$b212 000139666 7001_ $$aDeCarli, Charles$$b213 000139666 7001_ $$aKittur, Smita$$b214 000139666 7001_ $$aBorrie, Michael$$b215 000139666 7001_ $$aLee, T-Y$$b216 000139666 7001_ $$aBartha, Rob$$b217 000139666 7001_ $$aJohnson, Sterling$$b218 000139666 7001_ $$aAsthana, Sanjay$$b219 000139666 7001_ $$aCarlsson, Cynthia M$$b220 000139666 7001_ $$aPotkin, Steven G$$b221 000139666 7001_ $$aPreda, Adrian$$b222 000139666 7001_ $$aNguyen, Dana$$b223 000139666 7001_ $$aTariot, Pierre$$b224 000139666 7001_ $$aFleisher, Adam$$b225 000139666 7001_ $$aReeder, Stephanie$$b226 000139666 7001_ $$aBates, Vernice$$b227 000139666 7001_ $$aCapote, Horacio$$b228 000139666 7001_ $$aRainka, Michelle$$b229 000139666 7001_ $$aScharre, Douglas W$$b230 000139666 7001_ $$aKataki, Maria$$b231 000139666 7001_ $$aZimmerman, Earl A$$b232 000139666 7001_ $$aCelmins, Dzintra$$b233 000139666 7001_ $$aBrown, Alice D$$b234 000139666 7001_ $$aPearlson, Godfrey D$$b235 000139666 7001_ $$aBlank, Karen$$b236 000139666 7001_ $$aAnderson, Karen$$b237 000139666 7001_ $$aSaykin, Andrew J$$b238 000139666 7001_ $$aSantulli, Robert B$$b239 000139666 7001_ $$aSchwartz, Eben S$$b240 000139666 7001_ $$aSink, Kaycee M$$b241 000139666 7001_ $$aWilliamson, Jeff D$$b242 000139666 7001_ $$aGarg, Pradeep$$b243 000139666 7001_ $$aWatkins, Franklin$$b244 000139666 7001_ $$aOtt, Brian R$$b245 000139666 7001_ $$aQuerfurth, Henry$$b246 000139666 7001_ $$aTremont, Geoffrey$$b247 000139666 7001_ $$aSalloway, Stephen$$b248 000139666 7001_ $$aMalloy, Paul$$b249 000139666 7001_ $$aCorreia, Stephen$$b250 000139666 7001_ $$aRosen, Howard J$$b251 000139666 7001_ $$aMiller, Bruce L$$b252 000139666 7001_ $$aMintzer, Jacobo$$b253 000139666 7001_ $$aLongmire, Crystal Flynn$$b254 000139666 7001_ $$aSpicer, Kenneth$$b255 000139666 7001_ $$aFinger, Elizabether$$b256 000139666 7001_ $$aRachinsky, Irina$$b257 000139666 7001_ $$aRogers, John$$b258 000139666 7001_ $$aKertesz, Andrew$$b259 000139666 7001_ $$aDrost, Dick$$b260 000139666 7001_ $$aPomara, Nunzio$$b261 000139666 7001_ $$aHernando, Raymundo$$b262 000139666 7001_ $$aSarrael, Antero$$b263 000139666 7001_ $$aSchultz, Susan K$$b264 000139666 7001_ $$aBoles Ponto, Laura L$$b265 000139666 7001_ $$aShim, Hyungsub$$b266 000139666 7001_ $$aSmith, Karen Elizabeth$$b267 000139666 7001_ $$aRelkin, Norman$$b268 000139666 7001_ $$aChaing, Gloria$$b269 000139666 7001_ $$aRaudin, Lisa$$b270 000139666 7001_ $$aSmith, Amanda$$b271 000139666 7001_ $$aFargher, Kristin$$b272 000139666 7001_ $$aRaj, Balebail Ashok$$b273 000139666 77318 $$2Crossref$$3journal-article$$a10.1212/wnl.0000000000004643$$b : Ovid Technologies (Wolters Kluwer Health), 2017-10-18$$n20$$p2031-2038$$tNeurology$$v89$$x0028-3878$$y2017 000139666 773__ $$0PERI:(DE-600)1491874-2$$a10.1212/WNL.0000000000004643$$gVol. 89, no. 20, p. 2031 - 2038$$n20$$p2031-2038$$q89:20<2031 - 2038$$tNeurology$$v89$$x0028-3878$$y2017 000139666 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711511 000139666 909CO $$ooai:pub.dzne.de:139666$$pVDB 000139666 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810708$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE 000139666 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810283$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b3$$kDZNE 000139666 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000026$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b5$$kDZNE 000139666 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$aDE-HGF$$bForschungsbereich Gesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x0 000139666 9141_ $$y2017 000139666 915__ $$0StatID:(DE-HGF)0410$$2StatID$$aAllianz-Lizenz$$d2022-11-12$$wger 000139666 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-12 000139666 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-12 000139666 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-12 000139666 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-12 000139666 915__ $$0StatID:(DE-HGF)1110$$2StatID$$aDBCoverage$$bCurrent Contents - Clinical Medicine$$d2022-11-12 000139666 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2022-11-12 000139666 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROLOGY : 2021$$d2022-11-12 000139666 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-12 000139666 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNEUROLOGY : 2021$$d2022-11-12 000139666 9201_ $$0I:(DE-2719)1510100$$kClinical Dementia Research Rostock /Greifswald ; AG Teipel$$lClinical Dementia Research Rostock /Greifswald$$x0 000139666 980__ $$ajournal 000139666 980__ $$aVDB 000139666 980__ $$aI:(DE-2719)1510100 000139666 980__ $$aUNRESTRICTED