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@ARTICLE{Grothe:139666,
author = {Grothe, Michel J and Barthel, Henryk and Sepulcre, Jorge
and Dyrba, Martin and Sabri, Osama and Teipel, Stefan J and
Initiative, Alzheimer's Disease Neuroimaging and Weiner,
Michael and Aisen, Paul and Weiner, Michael and Aisen, Paul
and Petersen, Ronald and Jack, Clifford R and Jagust,
William and Trojanowki, John Q and Toga, Arthur W and
Beckett, Laurel and Green, Robert C and Saykin, Andrew J and
Morris, John and Liu, Enchi and Green, Robert C and Montine,
Tom and Petersen, Ronald and Aisen, Paul and Gamst, Anthony
and Thomas, Ronald G and Donohue, Michael and Walter, Sarah
and Gessert, Devon and Sather, Tamie and Beckett, Laurel and
Harvey, Danielle and Gamst, Anthony and Donohue, Michael and
Kornak, John and Jack, Clifford R and Dale, Anders and
Bernstein, Matthew and Felmlee, Joel and Fox, Nick and
Thompson, Paul and Schuff, Norbert and Alexander, Gene and
DeCarli, Charles and Jagust, William and Bandy, Dan and
Koeppe, Robert A and Foster, Norm and Reiman, Eric M and
Chen, Kewei and Mathis, Chet and Morris, John and Cairns,
Nigel J and Taylor-Reinwald, Lisa and Trojanowki, J. Q. and
Shaw, Les and Lee, Virginia M Y and Korecka, Magdalena and
Toga, Arthur W and Crawford, Karen and Neu, Scott and
Saykin, Andrew J and Foroud, Tatiana M and Potkin, Steven
and Shen, Li and Kachaturian, Zaven and Frank, Richard and
Snyder, Peter J and Molchan, Susan and Kaye, Jeffrey and
Quinn, Joseph and Lind, Betty and Dolen, Sara and Schneider,
Lon S and Pawluczyk, Sonia and Spann, Bryan M and Brewer,
James and Vanderswag, Helen and Heidebrink, Judith L and
Lord, Joanne L and Petersen, Ronald and Johnson, Kris and
Doody, Rachelle S and Villanueva-Meyer, Javier and
Chowdhury, Munir and Stern, Yaakov and Honig, Lawrence S and
Bell, Karen L and Morris, John C and Ances, Beau and
Carroll, Maria and Leon, Sue and Mintun, Mark A and
Schneider, Stacy and Marson, Daniel and Griffith, Randall
and Clark, David and Grossman, Hillel and Mitsis, Effie and
Romirowsky, Aliza and deToledo-Morrell, Leyla and Shah, Raj
C and Duara, Ranjan and Varon, Daniel and Roberts, Peggy and
Albert, Marilyn and Onyike, Chiadi and Kielb, Stephanie and
Rusinek, Henry and de Leon, Mony J and Glodzik, Lidia and De
Santi, Susan and Doraiswamy, P Murali and Petrella, Jeffrey
R and Coleman, R Edward and Arnold, Steven E and Karlawish,
Jason H and Wolk, David and Smith, Charles D and Jicha, Greg
and Hardy, Peter and Lopez, Oscar L and Oakley, MaryAnn and
Simpson, Donna M and Porsteinsson, Anton P and Goldstein,
Bonnie S and Martin, Kim and Makino, Kelly M and Ismail, M
Saleem and Brand, Connie and Mulnard, Ruth A and Thai, Gaby
and Mc-Adams-Ortiz, Catherine and Womack, Kyle and Mathews,
Dana and Quiceno, Mary and Diaz-Arrastia, Ramon and King,
Richard and Weiner, Myron and Martin-Cook, Kristen and
DeVous, Michael and Levey, Allan I and Lah, James J and
Cellar, Janet S and Burns, Jeffrey M and Anderson, Heather S
and Swerdlow, Russell H and Apostolova, Liana and Lu, Po H
and Bartzokis, George and Silverman, Daniel H S and Parfitt,
Francine and Johnson, Heather and Farlow, Martin R and Hake,
Ann Marie and Matthews, Brandy R and Herring, Scott and van
Dyck, Christopher H and Carson, Richard E and MacAvoy,
Martha G and Chertkow, Howard and Bergman, Howard and
Hosein, Chris and Black, Sandra and Stefanovic, Bojana and
Caldwell, Curtis and Robin Hsiung, Ging-Yuek and Feldman,
Howard and Mudge, Benita and Assaly, Michele and Kertesz,
Andrew and Rogers, John and Trost, Dick and Bernick, Charles
and Munic, Donna and Kerwin, Diana and Mesulam, Marek-Marsel
and Lipowski, Kristina and Wu, Chuang-Kuo and Johnson, Nancy
and Sadowsky, Carl and Martinez, Walter and Villena, Teresa
and Turner, Raymond Scott and Johnson, Kathleen and
Reynolds, Brigid and Sperling, Reisa A and Johnson, Keith A
and Marshall, Gad and Frey, Meghan and Yesavage, Jerome and
Taylor, Joy L and Lane, Barton and Rosen, Allyson and
Tinklenberg, Jared and Sabbagh, Marwan and Belden, Christine
and Jacobson, Sandra and Kowall, Neil and Killiany, Ronald
and Budson, Andrew E and Norbash, Alexander and Johnson,
Patricia Lynn and Obisesan, Thomas O and Wolday, Saba and
Bwayo, Salome K and Lerner, Alan and Hudson, Leon and
Ogrocki, Paula and Fletcher, Evan and Carmichael, Owen and
Olichney, John and DeCarli, Charles and Kittur, Smita and
Borrie, Michael and Lee, T-Y and Bartha, Rob and Johnson,
Sterling and Asthana, Sanjay and Carlsson, Cynthia M and
Potkin, Steven G and Preda, Adrian and Nguyen, Dana and
Tariot, Pierre and Fleisher, Adam and Reeder, Stephanie and
Bates, Vernice and Capote, Horacio and Rainka, Michelle and
Scharre, Douglas W and Kataki, Maria and Zimmerman, Earl A
and Celmins, Dzintra and Brown, Alice D and Pearlson,
Godfrey D and Blank, Karen and Anderson, Karen and Saykin,
Andrew J and Santulli, Robert B and Schwartz, Eben S and
Sink, Kaycee M and Williamson, Jeff D and Garg, Pradeep and
Watkins, Franklin and Ott, Brian R and Querfurth, Henry and
Tremont, Geoffrey and Salloway, Stephen and Malloy, Paul and
Correia, Stephen and Rosen, Howard J and Miller, Bruce L and
Mintzer, Jacobo and Longmire, Crystal Flynn and Spicer,
Kenneth and Finger, Elizabether and Rachinsky, Irina and
Rogers, John and Kertesz, Andrew and Drost, Dick and Pomara,
Nunzio and Hernando, Raymundo and Sarrael, Antero and
Schultz, Susan K and Boles Ponto, Laura L and Shim, Hyungsub
and Smith, Karen Elizabeth and Relkin, Norman and Chaing,
Gloria and Raudin, Lisa and Smith, Amanda and Fargher,
Kristin and Raj, Balebail Ashok},
title = {{I}n vivo staging of regional amyloid deposition.},
journal = {Neurology},
volume = {89},
number = {20},
issn = {0028-3878},
address = {[S.l.]},
publisher = {Ovid},
reportid = {DZNE-2020-05988},
pages = {2031-2038},
year = {2017},
abstract = {To estimate a regional progression pattern of amyloid
deposition from cross-sectional amyloid-sensitive PET data
and evaluate its potential for in vivo staging of an
individual's amyloid pathology.Multiregional analysis of
florbetapir (18F-AV45)-PET data was used to determine
individual amyloid distribution profiles in a sample of 667
participants from the Alzheimer's Disease Neuroimaging
Initiative cohort, including cognitively normal older
individuals (CN) as well as patients with mild cognitive
impairment and Alzheimer disease (AD) dementia. The
frequency of regional amyloid positivity across CN
individuals was used to construct a 4-stage model of
progressing amyloid pathology, and individual distribution
profiles were used to evaluate the consistency of this
hierarchical stage model across the full cohort.According to
a 4-stage model, amyloid deposition begins in temporobasal
and frontomedial areas, and successively affects the
remaining associative neocortex, primary sensory-motor areas
and the medial temporal lobe, and finally the striatum.
Amyloid deposition in these brain regions showed a highly
consistent hierarchical nesting across participants, where
only $2\%$ exhibited distribution profiles that deviated
from the staging scheme. The earliest in vivo amyloid stages
were mostly missed by conventional dichotomous
classification approaches based on global florbetapir-PET
signal, but were associated with significantly reduced CSF
Aβ42 levels. Advanced in vivo amyloid stages were most
frequent in patients with AD and correlated with cognitive
impairment in individuals without dementia.The highly
consistent regional hierarchy of PET-evidenced amyloid
deposition across participants resembles neuropathologic
observations and suggests a predictable regional sequence
that may be used to stage an individual's progress of
amyloid pathology in vivo.},
keywords = {Aged / Aged, 80 and over / Aging: metabolism / Alzheimer
Disease: diagnostic imaging / Alzheimer Disease: metabolism
/ Amyloid beta-Peptides: cerebrospinal fluid / Amyloid
beta-Peptides: metabolism / Aniline Compounds / Biomarkers:
metabolism / Cerebral Cortex: diagnostic imaging / Cerebral
Cortex: metabolism / Cognitive Dysfunction: diagnostic
imaging / Cognitive Dysfunction: metabolism /
Cross-Sectional Studies / Disease Progression / Ethylene
Glycols / Female / Humans / Male / Neostriatum: diagnostic
imaging / Neostriatum: metabolism / Peptide Fragments:
cerebrospinal fluid / Positron-Emission Tomography: methods
/ Amyloid beta-Peptides (NLM Chemicals) / Aniline Compounds
(NLM Chemicals) / Biomarkers (NLM Chemicals) / Ethylene
Glycols (NLM Chemicals) / Peptide Fragments (NLM Chemicals)
/ amyloid beta-protein (1-42) (NLM Chemicals) / florbetapir
(NLM Chemicals)},
cin = {Clinical Dementia Research Rostock /Greifswald ; AG Teipel},
ddc = {610},
cid = {I:(DE-2719)1510100},
pnm = {344 - Clinical and Health Care Research (POF3-344)},
pid = {G:(DE-HGF)POF3-344},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:29046362},
pmc = {pmc:PMC5711511},
doi = {10.1212/WNL.0000000000004643},
url = {https://pub.dzne.de/record/139666},
}
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