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@ARTICLE{Lerche:139678,
      author       = {Lerche, Stefanie and Schulte, Claudia and Srulijes, Karin
                      and Pilotto, Andrea and Rattay, Tim W and Hauser,
                      Ann-Kathrin and Stransky, Elke and Deuschle, Christian and
                      Csoti, Ilona and Lachmann, Ingolf and Zetterberg, Henrik and
                      Liepelt-Scarfone, Inga and Gasser, Thomas and Maetzler,
                      Walter and Berg, Daniela and Brockmann, Kathrin},
      title        = {{C}ognitive impairment in {G}lucocerebrosidase
                      ({GBA})-associated {PD}: {N}ot primarily associated with
                      cerebrospinal fluid {A}beta and {T}au profiles.},
      journal      = {Movement disorders},
      volume       = {32},
      number       = {12},
      issn         = {0885-3185},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {DZNE-2020-06000},
      pages        = {1780-1783},
      year         = {2017},
      abstract     = {A proportion of idiopathic Parkinson's disease patients
                      (PDidiopathic ) with dementia show altered CSF profiles of
                      amyloid β (Aβ) and Tau. PD patients with
                      Glucocerebrosidase (GBA) mutations (PDGBA ) present with
                      even more cognitive decline than seen in PDidiopathic .The
                      objective of this study was to evaluate whether CSF profiles
                      of Aβ and tau are associated with the prominent cognitive
                      impairment in PDGBA .CSF levels of Aβ1-42 , t-Tau, p-Tau,
                      and total alpha-synuclein were assessed in 479 participants
                      (50 PDGBA , 308 PDidiopathic , 121 healthy controls).Older
                      age was associated with cognitive impairment in PDGBA and
                      PDidiopathic . Despite prominent cognitive impairment, PDGBA
                      showed similar CSF levels of Aβ1-42 , t-Tau, and p-Tau as
                      seen in healthy controls. In contrast, lower levels of
                      Aβ1-42 and higher levels of t-Tau and p-Tau were associated
                      with worse cognitive performance in PDidiopathic .The
                      prominent cognitive impairment in PDGBA seems not primarily
                      associated with Aβ and Tau profiles in CSF. © 2017
                      International Parkinson and Movement Disorder Society.},
      keywords     = {Adolescent / Adult / Aged / Aged, 80 and over / Amyloid
                      beta-Peptides: cerebrospinal fluid / Cognition Disorders:
                      etiology / Female / Glucosylceramidase: genetics / Humans /
                      Male / Middle Aged / Mutation: genetics / Neuropsychological
                      Tests / Parkinson Disease: cerebrospinal fluid / Parkinson
                      Disease: complications / Parkinson Disease: genetics /
                      Peptide Fragments: cerebrospinal fluid / Retrospective
                      Studies / Severity of Illness Index / Statistics,
                      Nonparametric / Young Adult / tau Proteins: cerebrospinal
                      fluid / Amyloid beta-Peptides (NLM Chemicals) / Peptide
                      Fragments (NLM Chemicals) / amyloid beta-protein (1-42) (NLM
                      Chemicals) / tau Proteins (NLM Chemicals) /
                      Glucosylceramidase (NLM Chemicals)},
      cin          = {Tübingen Pre 2020 / AG Berg / AG Gasser 1 / AG Maetzler},
      ddc          = {610},
      cid          = {I:(DE-2719)6000018 / I:(DE-2719)5000055 /
                      I:(DE-2719)1210000 / I:(DE-2719)5000024},
      pnm          = {344 - Clinical and Health Care Research (POF3-344) / 345 -
                      Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-344 / G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29094781},
      doi          = {10.1002/mds.27199},
      url          = {https://pub.dzne.de/record/139678},
}