TY  - JOUR
AU  - Hansen, Niels
AU  - Chaieb, Leila
AU  - Derner, Marlene
AU  - Hampel, Kevin G
AU  - Elger, Christian E
AU  - Surges, Rainer
AU  - Staresina, Bernhard
AU  - Axmacher, Nikolai
AU  - Fell, Juergen
TI  - Memory encoding-related anterior hippocampal potentials are modulated by deep brain stimulation of the entorhinal area.
JO  - Hippocampus
VL  - 28
IS  - 1
SN  - 1050-9631
CY  - New York, NY [u.a.]
PB  - Wiley
M1  - DZNE-2020-06010
SP  - 12-17
PY  - 2018
AB  - Deep brain stimulation (DBS) of the human entorhinal area using 50 Hz pulses has revealed conflicting results regarding memory performance. Moreover, its impact on memory-related hippocampal potentials has not yet been investigated.We recorded data from seven epilepsy patients implanted with depth electrodes in the entorhinal cortex, hippocampus, amygdala, and parahippocampal cortex. Entorhinal DBS (bipolar, biphasic 50 Hz pulses, on- and off-cycles of 15 s) was applied with low amplitude (0.1 mA) to resemble physiologic conditions. During DBS on- and off-periods, patients learned noun-color associations that were later tested.During entorhinal DBS we observed more positive deflections of event-related potentials (ranging from 700 to 950 ms) in the anterior hippocampus for the on- vs. off-condition. We detected no effects in the amygdala, mid hippocampus and parahippocampal cortex. On the behavioral level, no differences in memory performance (item and source memory) were apparent in the on- vs. off-condition, neither across all trials nor across patients.Our findings indicate that entorhinal DBS with low amplitude has an impact on memory encoding-related potentials within the anterior hippocampus, but not on memory performance per se.
KW  - Adult
KW  - Amygdala: physiology
KW  - Amygdala: physiopathology
KW  - Association Learning: physiology
KW  - Deep Brain Stimulation: methods
KW  - Entorhinal Cortex: physiology
KW  - Entorhinal Cortex: physiopathology
KW  - Epilepsy, Temporal Lobe: physiopathology
KW  - Epilepsy, Temporal Lobe: psychology
KW  - Epilepsy, Temporal Lobe: therapy
KW  - Evoked Potentials
KW  - Female
KW  - Hippocampus: physiology
KW  - Hippocampus: physiopathology
KW  - Humans
KW  - Male
KW  - Memory: physiology
LB  - PUB:(DE-HGF)16
C6  - pmid:29034573
DO  - DOI:10.1002/hipo.22808
UR  - https://pub.dzne.de/record/139688
ER  -