000139722 001__ 139722
000139722 005__ 20240826163725.0
000139722 0247_ $$2doi$$a10.15252/emmm.201707825
000139722 0247_ $$2pmid$$apmid:29208638
000139722 0247_ $$2pmc$$apmc:PMC5760857
000139722 0247_ $$2ISSN$$a1715-4684
000139722 0247_ $$2ISSN$$a1757-4676
000139722 0247_ $$2ISSN$$a1757-4684
000139722 0247_ $$2altmetric$$aaltmetric:30031306
000139722 037__ $$aDZNE-2020-06044
000139722 041__ $$aEnglish
000139722 082__ $$a610
000139722 1001_ $$0P:(DE-2719)2810770$$aMartinez Hernandez, Ana$$b0$$eFirst author$$udzne
000139722 245__ $$aThe diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology.
000139722 260__ $$aHeidelberg$$bEMBO Press$$c2018
000139722 264_1 $$2Crossref$$3online$$bEMBO$$c2017-12-05
000139722 264_1 $$2Crossref$$3print$$bEMBO$$c2018-01-01
000139722 3367_ $$2DRIVER$$aarticle
000139722 3367_ $$2DataCite$$aOutput Types/Journal article
000139722 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1724675292_22476
000139722 3367_ $$2BibTeX$$aARTICLE
000139722 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000139722 3367_ $$00$$2EndNote$$aJournal Article
000139722 520__ $$aAlzheimer's disease is a devastating neurodegenerative disease eventually leading to dementia. An effective treatment does not yet exist. Here we show that oral application of the compound anle138b restores hippocampal synaptic and transcriptional plasticity as well as spatial memory in a mouse model for Alzheimer's disease, when given orally before or after the onset of pathology. At the mechanistic level, we provide evidence that anle138b blocks the activity of conducting Aβ pores without changing the membrane embedded Aβ-oligomer structure. In conclusion, our data suggest that anle138b is a novel and promising compound to treat AD-related pathology that should be investigated further.
000139722 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000139722 536__ $$0G:(DE-HGF)POF3-344$$a344 - Clinical and Health Care Research (POF3-344)$$cPOF3-344$$fPOF III$$x1
000139722 542__ $$2Crossref$$i2017-12-05$$uhttp://creativecommons.org/licenses/by/4.0/
000139722 542__ $$2Crossref$$i2017-12-05$$uhttp://doi.wiley.com/10.1002/tdm_license_1.1
000139722 588__ $$aDataset connected to CrossRef, PubMed,
000139722 650_7 $$2NLM Chemicals$$a3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole
000139722 650_7 $$2NLM Chemicals$$aAmyloid beta-Peptides
000139722 650_7 $$2NLM Chemicals$$aBenzodioxoles
000139722 650_7 $$2NLM Chemicals$$aPyrazoles
000139722 650_2 $$2MeSH$$aAlzheimer Disease: drug therapy
000139722 650_2 $$2MeSH$$aAlzheimer Disease: genetics
000139722 650_2 $$2MeSH$$aAlzheimer Disease: metabolism
000139722 650_2 $$2MeSH$$aAlzheimer Disease: physiopathology
000139722 650_2 $$2MeSH$$aAmyloid beta-Peptides: genetics
000139722 650_2 $$2MeSH$$aAmyloid beta-Peptides: metabolism
000139722 650_2 $$2MeSH$$aAnimals
000139722 650_2 $$2MeSH$$aBenzodioxoles: pharmacology
000139722 650_2 $$2MeSH$$aBenzodioxoles: therapeutic use
000139722 650_2 $$2MeSH$$aDisease Models, Animal
000139722 650_2 $$2MeSH$$aHippocampus: drug effects
000139722 650_2 $$2MeSH$$aHippocampus: metabolism
000139722 650_2 $$2MeSH$$aHippocampus: physiopathology
000139722 650_2 $$2MeSH$$aMale
000139722 650_2 $$2MeSH$$aMice
000139722 650_2 $$2MeSH$$aMice, Inbred C57BL
000139722 650_2 $$2MeSH$$aNeuronal Plasticity: drug effects
000139722 650_2 $$2MeSH$$aPhenotype
000139722 650_2 $$2MeSH$$aPyrazoles: pharmacology
000139722 650_2 $$2MeSH$$aPyrazoles: therapeutic use
000139722 650_2 $$2MeSH$$aSpatial Memory: drug effects
000139722 650_2 $$2MeSH$$aTranscriptome: drug effects
000139722 7001_ $$0P:(DE-2719)2811034$$aUrbanke, Hendrik$$b1$$udzne
000139722 7001_ $$aGillman, Alan L$$b2
000139722 7001_ $$aLee, Joon$$b3
000139722 7001_ $$aRyazanov, Sergey$$b4
000139722 7001_ $$aAgbemenyah, Hope Y$$b5
000139722 7001_ $$0P:(DE-2719)2810482$$aBenito, Eva$$b6$$udzne
000139722 7001_ $$0P:(DE-2719)2811223$$aJain, Gaurav$$b7$$udzne
000139722 7001_ $$aKaurani, Lalit$$b8
000139722 7001_ $$aGrigorian, Gayane$$b9
000139722 7001_ $$aLeonov, Andrei$$b10
000139722 7001_ $$0P:(DE-2719)9000418$$aRezaei-Ghaleh, Nasrollah$$b11$$udzne
000139722 7001_ $$0P:(DE-2719)2814028$$aWilken, Petra$$b12$$udzne
000139722 7001_ $$aArce, Fernando Teran$$b13
000139722 7001_ $$0P:(DE-2719)2662292$$aWagner, Jens$$b14$$udzne
000139722 7001_ $$0P:(DE-2719)2679991$$aFuhrmann, Martin$$b15$$udzne
000139722 7001_ $$aCaruana, Mario$$b16
000139722 7001_ $$aCamilleri, Angelique$$b17
000139722 7001_ $$aVassallo, Neville$$b18
000139722 7001_ $$0P:(DE-2719)2810591$$aZweckstetter, Markus$$b19$$udzne
000139722 7001_ $$aBenz, Roland$$b20
000139722 7001_ $$0P:(DE-HGF)0$$aGiese, Armin$$b21
000139722 7001_ $$0P:(DE-2719)2812035$$aSchneider, Anja$$b22$$udzne
000139722 7001_ $$0P:(DE-HGF)0$$aKorte, Martin$$b23$$eCorresponding author
000139722 7001_ $$aLal, Ratnesh$$b24
000139722 7001_ $$aGriesinger, Christian$$b25
000139722 7001_ $$aEichele, Gregor$$b26
000139722 7001_ $$0P:(DE-2719)2000047$$aFischer, Andre$$b27$$eLast author$$udzne
000139722 77318 $$2Crossref$$3journal-article$$a10.15252/emmm.201707825$$b : EMBO, 2017-12-05$$n1$$p32-47$$tEMBO Molecular Medicine$$v10$$x1757-4676$$y2017
000139722 773__ $$0PERI:(DE-600)2485479-7$$a10.15252/emmm.201707825$$gVol. 10, no. 1, p. 32 - 47$$n1$$p32-47$$q10:1<32 - 47$$tEMBO molecular medicine$$v10$$x1757-4676$$y2018
000139722 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5760857
000139722 8564_ $$uhttps://pub.dzne.de/record/139722/files/DZNE-2020-06044.pdf$$yOpenAccess
000139722 8564_ $$uhttps://pub.dzne.de/record/139722/files/DZNE-2020-06044.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000139722 909CO $$ooai:pub.dzne.de:139722$$popenaire$$popen_access$$pVDB$$pdriver$$pdnbdelivery
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810770$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b0$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811034$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810482$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b6$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2811223$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b7$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000418$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b11$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2814028$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b12$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2662292$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b14$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2679991$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b15$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2810591$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b19$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2812035$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b22$$kDZNE
000139722 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)2000047$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b27$$kDZNE
000139722 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000139722 9131_ $$0G:(DE-HGF)POF3-344$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vClinical and Health Care Research$$x1
000139722 9141_ $$y2018
000139722 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2022-11-29
000139722 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2022-11-29
000139722 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000139722 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bEMBO MOL MED : 2021$$d2022-11-29
000139722 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal$$d2021-07-19T13:19:31Z
000139722 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ$$d2021-07-19T13:19:31Z
000139722 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bEMBO MOL MED : 2021$$d2022-11-29
000139722 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2022-11-29
000139722 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000139722 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review, Double blind peer review$$d2021-07-19T13:19:31Z
000139722 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2022-11-29
000139722 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2022-11-29
000139722 9201_ $$0I:(DE-2719)1410002$$kAG Fischer ; AG Fischer$$lEpigenetics and Systems Medicine in Neurodegenerative Diseases$$x0
000139722 9201_ $$0I:(DE-2719)1410001$$kAG Zweckstetter$$lTranslational Structural Biology$$x1
000139722 9201_ $$0I:(DE-2719)1011004$$kAG Fuhrmann$$lNeuroimmunology and Imaging$$x2
000139722 9201_ $$0I:(DE-2719)1440011$$kAG Schneider Göttingen$$lTranslational Dementia Research Göttingen$$x3
000139722 980__ $$ajournal
000139722 980__ $$aVDB
000139722 980__ $$aI:(DE-2719)1410002
000139722 980__ $$aI:(DE-2719)1410001
000139722 980__ $$aI:(DE-2719)1011004
000139722 980__ $$aI:(DE-2719)1440011
000139722 980__ $$aUNRESTRICTED
000139722 9801_ $$aFullTexts
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1039/c1sm05162h$$o10.1039/c1sm05162h
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.90.2.567$$o10.1073/pnas.90.2.567
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1172/JCI79942$$o10.1172/JCI79942
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0005-2736(78)90269-9$$o10.1016/0005-2736(78)90269-9
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0910723107$$o10.1073/pnas.0910723107
000139722 999C5 $$2Crossref$$oBrand AH 1993$$y1993
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/bi2017427$$o10.1021/bi2017427
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/jp2108126$$o10.1021/jp2108126
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/bi300257e$$o10.1021/bi300257e
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroscience.2004.12.025$$o10.1016/j.neuroscience.2004.12.025
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1083/jcb.201104133$$o10.1083/jcb.201104133
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0813355106$$o10.1073/pnas.0813355106
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature11233$$o10.1038/nature11233
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.sbi.2014.12.004$$o10.1016/j.sbi.2014.12.004
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nsmb.1437$$o10.1038/nsmb.1437
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/embj.201387637$$o10.1002/embj.201387637
000139722 999C5 $$2Crossref$$oFischer A 2014$$y2014
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neuroimage.2015.11.039$$o10.1016/j.neuroimage.2015.11.039
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/jp5040954$$o10.1021/jp5040954
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1471-4159.2011.07575.x$$o10.1111/j.1471-4159.2011.07575.x
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/BF01923594$$o10.1007/BF01923594
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nrm2101$$o10.1038/nrm2101
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1042/bj3110001$$o10.1042/bj3110001
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/anie.200802808$$o10.1002/anie.200802808
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.tibs.2007.10.007$$o10.1016/j.tibs.2007.10.007
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S1389-0344(01)00067-3$$o10.1016/S1389-0344(01)00067-3
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1093/hmg/ddh019$$o10.1093/hmg/ddh019
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.4027-13.2014$$o10.1523/JNEUROSCI.4027-13.2014
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.neulet.2005.08.028$$o10.1016/j.neulet.2005.08.028
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1021/bi500587p$$o10.1021/bi500587p
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1096/fj.01-0377com$$o10.1096/fj.01-0377com
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M605048200$$o10.1074/jbc.M605048200
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s12035-013-8608-2$$o10.1007/s12035-013-8608-2
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1186/s13059-014-0550-8$$o10.1186/s13059-014-0550-8
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.celrep.2014.12.041$$o10.1016/j.celrep.2014.12.041
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1126/science.1089035$$o10.1126/science.1089035
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/0165-0270(84)90007-4$$o10.1016/0165-0270(84)90007-4
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/194979a0$$o10.1038/194979a0
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1056/NEJMra0909142$$o10.1056/NEJMra0909142
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1073/pnas.0502066102$$o10.1073/pnas.0502066102
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/j.1601-183X.2006.00221.x$$o10.1111/j.1601-183X.2006.00221.x
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1002/anie.201402636$$o10.1002/anie.201402636
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.15252/emmm.201606210$$o10.15252/emmm.201606210
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nature19323$$o10.1038/nature19323
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1523/JNEUROSCI.4970-06.2007$$o10.1523/JNEUROSCI.4970-06.2007
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1515/REVNEURO.2004.15.4.267$$o10.1515/REVNEURO.2004.15.4.267
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/j.cell.2013.02.004$$o10.1016/j.cell.2013.02.004
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1177/002215540205000403$$o10.1177/002215540205000403
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1038/nn0805-977$$o10.1038/nn0805-977
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1074/jbc.M109.062422$$o10.1074/jbc.M109.062422
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1111/jnc.12715$$o10.1111/jnc.12715
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00401-013-1114-9$$o10.1007/s00401-013-1114-9
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1007/s00401-015-1483-3$$o10.1007/s00401-015-1483-3
000139722 999C5 $$2Crossref$$9-- missing cx lookup --$$a10.1016/S0006-3495(72)86095-8$$o10.1016/S0006-3495(72)86095-8