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@ARTICLE{MartinezHernandez:139722,
      author       = {Martinez Hernandez, Ana and Urbanke, Hendrik and Gillman,
                      Alan L and Lee, Joon and Ryazanov, Sergey and Agbemenyah,
                      Hope Y and Benito, Eva and Jain, Gaurav and Kaurani, Lalit
                      and Grigorian, Gayane and Leonov, Andrei and Rezaei-Ghaleh,
                      Nasrollah and Wilken, Petra and Arce, Fernando Teran and
                      Wagner, Jens and Fuhrmann, Martin and Caruana, Mario and
                      Camilleri, Angelique and Vassallo, Neville and Zweckstetter,
                      Markus and Benz, Roland and Giese, Armin and Schneider, Anja
                      and Korte, Martin and Lal, Ratnesh and Griesinger, Christian
                      and Eichele, Gregor and Fischer, Andre},
      title        = {{T}he diphenylpyrazole compound anle138b blocks {A}β
                      channels and rescues disease phenotypes in a mouse model for
                      amyloid pathology.},
      journal      = {EMBO molecular medicine},
      volume       = {10},
      number       = {1},
      issn         = {1757-4676},
      address      = {Heidelberg},
      publisher    = {EMBO Press},
      reportid     = {DZNE-2020-06044},
      pages        = {32-47},
      year         = {2018},
      abstract     = {Alzheimer's disease is a devastating neurodegenerative
                      disease eventually leading to dementia. An effective
                      treatment does not yet exist. Here we show that oral
                      application of the compound anle138b restores hippocampal
                      synaptic and transcriptional plasticity as well as spatial
                      memory in a mouse model for Alzheimer's disease, when given
                      orally before or after the onset of pathology. At the
                      mechanistic level, we provide evidence that anle138b blocks
                      the activity of conducting Aβ pores without changing the
                      membrane embedded Aβ-oligomer structure. In conclusion, our
                      data suggest that anle138b is a novel and promising compound
                      to treat AD-related pathology that should be investigated
                      further.},
      keywords     = {Alzheimer Disease: drug therapy / Alzheimer Disease:
                      genetics / Alzheimer Disease: metabolism / Alzheimer
                      Disease: physiopathology / Amyloid beta-Peptides: genetics /
                      Amyloid beta-Peptides: metabolism / Animals / Benzodioxoles:
                      pharmacology / Benzodioxoles: therapeutic use / Disease
                      Models, Animal / Hippocampus: drug effects / Hippocampus:
                      metabolism / Hippocampus: physiopathology / Male / Mice /
                      Mice, Inbred C57BL / Neuronal Plasticity: drug effects /
                      Phenotype / Pyrazoles: pharmacology / Pyrazoles: therapeutic
                      use / Spatial Memory: drug effects / Transcriptome: drug
                      effects /
                      3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazole (NLM
                      Chemicals) / Amyloid beta-Peptides (NLM Chemicals) /
                      Benzodioxoles (NLM Chemicals) / Pyrazoles (NLM Chemicals)},
      cin          = {AG Fischer ; AG Fischer / AG Zweckstetter / AG Fuhrmann /
                      AG Schneider Göttingen},
      ddc          = {610},
      cid          = {I:(DE-2719)1410002 / I:(DE-2719)1410001 /
                      I:(DE-2719)1011004 / I:(DE-2719)1440011},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342) / 344
                      - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-342 / G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29208638},
      pmc          = {pmc:PMC5760857},
      doi          = {10.15252/emmm.201707825},
      url          = {https://pub.dzne.de/record/139722},
}