% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Fukui:139726,
      author       = {Fukui, Hirokazu and Rünker, Annette and Fabel, Klaus and
                      Buchholz, Frank and Kempermann, Gerd},
      title        = {{T}ranscription factor {R}unx1 is pro-neurogenic in adult
                      hippocampal precursor cells.},
      journal      = {PLOS ONE},
      volume       = {13},
      number       = {1},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {DZNE-2020-06048},
      pages        = {e0190789},
      year         = {2018},
      abstract     = {Transcription factor Runx1 (Runt Related Transcription
                      Factor 1), plays an important role in the differentiation of
                      hematopoetic stem cells, angiogenesis and the development of
                      nociceptive neurons. These known functions have in common
                      that they relate to lineage decisions. We thus asked whether
                      such role might also be found for Runx1 in adult hippocampal
                      neurogenesis as a process, in which such decisions have to
                      be regulated lifelong. Runx1 shows a widespread low
                      expression in the adult mouse brain, not particularly
                      prominent in the hippocampus and the resident neural
                      precursor cells. Isoforms 1 and 2 of Runx1 (but not 3 to 5)
                      driven by the proximal promoter were expressed in
                      hippocampal precursor cells ex vivo, albeit again at very
                      low levels, and were markedly increased after stimulation
                      with TGF-β1. Under differentiation conditions (withdrawal
                      of growth factors) Runx1 became down-regulated.
                      Overexpression of Runx1 in vitro reduced proliferation,
                      increased survival of precursor cells by reducing apoptosis,
                      and increased neuronal differentiation, while slightly
                      reducing dendritic morphology and complexity. Transfection
                      with dominant-negative Runx1 in hippocampal precursor cells
                      in vitro did not result in differences in neurogenesis.
                      Hippocampal expression of Runx1 correlated with adult
                      neurogenesis (precursor cell proliferation) across BXD
                      recombinant strains of mice and covarying transcripts
                      enriched in the GO categories 'neural precursor cell
                      proliferation' and 'neuron differentiation'. Runx1 is thus a
                      plausible candidate gene to be involved in regulating
                      initial differentiation-related steps of adult neurogenesis.
                      It seems, however, that the relative contribution of Runx1
                      to such effect is complementary and will explain only small
                      parts of the cell-autonomous pro-differentiation effect.},
      keywords     = {Alternative Splicing / Animals / Apoptosis: physiology /
                      Cell Survival: physiology / Cells, Cultured / Core Binding
                      Factor Alpha 2 Subunit: genetics / Core Binding Factor Alpha
                      2 Subunit: metabolism / Dendrites: metabolism / Hippocampus:
                      cytology / Hippocampus: metabolism / Mice, Inbred C57BL /
                      Mice, Inbred DBA / Neural Stem Cells: cytology / Neural Stem
                      Cells: metabolism / Neurogenesis: physiology / Protein
                      Isoforms / RNA, Messenger: metabolism / Running: physiology
                      / Species Specificity / Systems Biology / Transcriptome /
                      Transfection / Transforming Growth Factor beta1:
                      administration $\&$ dosage / Transforming Growth Factor
                      beta1: metabolism / Volition / Core Binding Factor Alpha 2
                      Subunit (NLM Chemicals) / Protein Isoforms (NLM Chemicals) /
                      RNA, Messenger (NLM Chemicals) / Runx1 protein, mouse (NLM
                      Chemicals) / Transforming Growth Factor beta1 (NLM
                      Chemicals)},
      cin          = {AG Kempermann 1 / Dresden Pre 2020},
      ddc          = {610},
      cid          = {I:(DE-2719)1710001 / I:(DE-2719)6000013},
      pnm          = {342 - Disease Mechanisms and Model Systems (POF3-342)},
      pid          = {G:(DE-HGF)POF3-342},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29324888},
      pmc          = {pmc:PMC5764282},
      doi          = {10.1371/journal.pone.0190789},
      url          = {https://pub.dzne.de/record/139726},
}