000139746 001__ 139746
000139746 005__ 20240321220657.0
000139746 0247_ $$2doi$$a10.1016/j.ydbio.2017.09.028
000139746 0247_ $$2pmid$$apmid:29291970
000139746 0247_ $$2ISSN$$a0012-1606
000139746 0247_ $$2ISSN$$a1095-564X
000139746 0247_ $$2altmetric$$aaltmetric:30975626
000139746 037__ $$aDZNE-2020-06068
000139746 041__ $$aEnglish
000139746 082__ $$a570
000139746 1001_ $$aLlonch, Sílvia$$b0
000139746 245__ $$aOrganoid technology for retinal repair.
000139746 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2018
000139746 264_1 $$2Crossref$$3print$$bElsevier BV$$c2018-01-01
000139746 3367_ $$2DRIVER$$aarticle
000139746 3367_ $$2DataCite$$aOutput Types/Journal article
000139746 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1685004228_32154$$xReview Article
000139746 3367_ $$2BibTeX$$aARTICLE
000139746 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000139746 3367_ $$00$$2EndNote$$aJournal Article
000139746 520__ $$aA major cause for vision impairment and blindness in industrialized countries is the loss of the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main characteristics found in retinal degeneration diseases, such as Retinitis Pigmentosa or age-related macular degeneration. The lack of effective therapies to stop photoreceptor loss together with the absence of significant intrinsic regeneration in the human retina converts such degenerative diseases into permanent conditions that are currently irreversible. Cell replacement by means of photoreceptor transplantation has been proposed as a potential approach to tackle cell loss in the retina. Since the first attempt of photoreceptor transplantation in humans, about twenty years ago, several research groups have focused in the development and improvement of technologies necessary to bring cell transplantation for retinal degeneration diseases to reality. Progress in recent years in the generation of human tissue derived from pluripotent stem cells (PSCs) has significantly improved our tools to study human development and disease in the dish. Particularly the availability of 3D culture systems for the generation of PSC-derived organoids, including the human retina, has dramatically increased access to human material for basic and medical research. In this review, we focus on important milestones towards the generation of transplantable photoreceptor precursors from PSC-derived retinal organoids and discuss recent pre-clinical transplantation studies using organoid-derived photoreceptors in context to related in vivo work using primary photoreceptors as donor material. Additionally, we summarize remaining challenges for developing photoreceptor transplantation towards clinical application.
000139746 536__ $$0G:(DE-HGF)POF3-342$$a342 - Disease Mechanisms and Model Systems (POF3-342)$$cPOF3-342$$fPOF III$$x0
000139746 542__ $$2Crossref$$i2018-01-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000139746 542__ $$2Crossref$$i2017-10-06$$uhttp://creativecommons.org/licenses/by-nc-nd/4.0/
000139746 588__ $$aDataset connected to CrossRef, PubMed,
000139746 650_7 $$2NLM Chemicals$$aCulture Media, Serum-Free
000139746 650_2 $$2MeSH$$aTranslational Research, Biomedical
000139746 650_2 $$2MeSH$$aAnimals
000139746 650_2 $$2MeSH$$aCellular Reprogramming Techniques
000139746 650_2 $$2MeSH$$aCulture Media, Serum-Free: pharmacology
000139746 650_2 $$2MeSH$$aEmbryonic Stem Cells: cytology
000139746 650_2 $$2MeSH$$aEmbryonic Stem Cells: drug effects
000139746 650_2 $$2MeSH$$aHumans
000139746 650_2 $$2MeSH$$aInduced Pluripotent Stem Cells: transplantation
000139746 650_2 $$2MeSH$$aMice
000139746 650_2 $$2MeSH$$aMorphogenesis
000139746 650_2 $$2MeSH$$aOrganoids: transplantation
000139746 650_2 $$2MeSH$$aPhotoreceptor Cells, Vertebrate: transplantation
000139746 650_2 $$2MeSH$$aPluripotent Stem Cells: transplantation
000139746 650_2 $$2MeSH$$aRetina: cytology
000139746 650_2 $$2MeSH$$aRetinal Degeneration: therapy
000139746 650_2 $$2MeSH$$aSpecies Specificity
000139746 650_2 $$2MeSH$$aTissue Culture Techniques
000139746 650_2 $$2MeSH$$aTranslational Medical Research
000139746 7001_ $$0P:(DE-2719)9000042$$aCarido, Magdalena$$b1$$udzne
000139746 7001_ $$0P:(DE-HGF)0$$aAder, Marius$$b2$$eCorresponding author
000139746 77318 $$2Crossref$$3journal-article$$a10.1016/j.ydbio.2017.09.028$$b : Elsevier BV, 2018-01-01$$n2$$p132-143$$tDevelopmental Biology$$v433$$x0012-1606$$y2018
000139746 773__ $$0PERI:(DE-600)1463203-2$$a10.1016/j.ydbio.2017.09.028$$gVol. 433, no. 2, p. 132 - 143$$n2$$p132-143$$q433:2<132 - 143$$tDevelopmental biology$$v433$$x0012-1606$$y2018
000139746 8564_ $$uhttps://pub.dzne.de/record/139746/files/DZNE-2020-06068.pdf$$yOpenAccess
000139746 8564_ $$uhttps://pub.dzne.de/record/139746/files/DZNE-2020-06068.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000139746 909CO $$ooai:pub.dzne.de:139746$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000139746 9101_ $$0I:(DE-588)1065079516$$6P:(DE-2719)9000042$$aDeutsches Zentrum für Neurodegenerative Erkrankungen$$b1$$kDZNE
000139746 9131_ $$0G:(DE-HGF)POF3-342$$1G:(DE-HGF)POF3-340$$2G:(DE-HGF)POF3-300$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bGesundheit$$lErkrankungen des Nervensystems$$vDisease Mechanisms and Model Systems$$x0
000139746 9141_ $$y2018
000139746 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000139746 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000139746 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz$$d2023-03-30$$wger
000139746 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bDEV BIOL : 2021$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record$$d2023-03-30
000139746 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5$$d2023-03-30
000139746 9201_ $$0I:(DE-2719)1710004$$kAG Karl$$lRetinal Regeneration and Degeneration$$x0
000139746 980__ $$ajournal
000139746 980__ $$aVDB
000139746 980__ $$aUNRESTRICTED
000139746 980__ $$aI:(DE-2719)1710004
000139746 9801_ $$aFullTexts