Home > Publications Database > Organoid technology for retinal repair. > print

001     139746
005     20240321220657.0
024 7 _ |a 10.1016/j.ydbio.2017.09.028
|2 doi
024 7 _ |a pmid:29291970
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024 7 _ |a 0012-1606
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024 7 _ |a 1095-564X
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024 7 _ |a altmetric:30975626
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037 _ _ |a DZNE-2020-06068
041 _ _ |a English
082 _ _ |a 570
100 1 _ |a Llonch, Sílvia
|b 0
245 _ _ |a Organoid technology for retinal repair.
260 _ _ |a Amsterdam [u.a.]
|c 2018
|b Elsevier
264 _ 1 |3 print
|2 Crossref
|b Elsevier BV
|c 2018-01-01
336 7 _ |a article
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336 7 _ |a Output Types/Journal article
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336 7 _ |a Journal Article
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|s 1685004228_32154
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a A major cause for vision impairment and blindness in industrialized countries is the loss of the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main characteristics found in retinal degeneration diseases, such as Retinitis Pigmentosa or age-related macular degeneration. The lack of effective therapies to stop photoreceptor loss together with the absence of significant intrinsic regeneration in the human retina converts such degenerative diseases into permanent conditions that are currently irreversible. Cell replacement by means of photoreceptor transplantation has been proposed as a potential approach to tackle cell loss in the retina. Since the first attempt of photoreceptor transplantation in humans, about twenty years ago, several research groups have focused in the development and improvement of technologies necessary to bring cell transplantation for retinal degeneration diseases to reality. Progress in recent years in the generation of human tissue derived from pluripotent stem cells (PSCs) has significantly improved our tools to study human development and disease in the dish. Particularly the availability of 3D culture systems for the generation of PSC-derived organoids, including the human retina, has dramatically increased access to human material for basic and medical research. In this review, we focus on important milestones towards the generation of transplantable photoreceptor precursors from PSC-derived retinal organoids and discuss recent pre-clinical transplantation studies using organoid-derived photoreceptors in context to related in vivo work using primary photoreceptors as donor material. Additionally, we summarize remaining challenges for developing photoreceptor transplantation towards clinical application.
536 _ _ |a 342 - Disease Mechanisms and Model Systems (POF3-342)
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542 _ _ |i 2018-01-01
|2 Crossref
|u https://www.elsevier.com/tdm/userlicense/1.0/
542 _ _ |i 2017-10-06
|2 Crossref
|u http://creativecommons.org/licenses/by-nc-nd/4.0/
588 _ _ |a Dataset connected to CrossRef, PubMed,
650 _ 7 |a Culture Media, Serum-Free
|2 NLM Chemicals
650 _ 2 |a Translational Research, Biomedical
|2 MeSH
650 _ 2 |a Animals
|2 MeSH
650 _ 2 |a Cellular Reprogramming Techniques
|2 MeSH
650 _ 2 |a Culture Media, Serum-Free: pharmacology
|2 MeSH
650 _ 2 |a Embryonic Stem Cells: cytology
|2 MeSH
650 _ 2 |a Embryonic Stem Cells: drug effects
|2 MeSH
650 _ 2 |a Humans
|2 MeSH
650 _ 2 |a Induced Pluripotent Stem Cells: transplantation
|2 MeSH
650 _ 2 |a Mice
|2 MeSH
650 _ 2 |a Morphogenesis
|2 MeSH
650 _ 2 |a Organoids: transplantation
|2 MeSH
650 _ 2 |a Photoreceptor Cells, Vertebrate: transplantation
|2 MeSH
650 _ 2 |a Pluripotent Stem Cells: transplantation
|2 MeSH
650 _ 2 |a Retina: cytology
|2 MeSH
650 _ 2 |a Retinal Degeneration: therapy
|2 MeSH
650 _ 2 |a Species Specificity
|2 MeSH
650 _ 2 |a Tissue Culture Techniques
|2 MeSH
650 _ 2 |a Translational Medical Research
|2 MeSH
700 1 _ |a Carido, Magdalena
|0 P:(DE-2719)9000042
|b 1
|u dzne
700 1 _ |a Ader, Marius
|0 P:(DE-HGF)0
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|e Corresponding author
773 1 8 |a 10.1016/j.ydbio.2017.09.028
|b : Elsevier BV, 2018-01-01
|n 2
|p 132-143
|3 journal-article
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|t Developmental Biology
|v 433
|y 2018
|x 0012-1606
773 _ _ |a 10.1016/j.ydbio.2017.09.028
|g Vol. 433, no. 2, p. 132 - 143
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856 4 _ |y OpenAccess
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910 1 _ |a Deutsches Zentrum für Neurodegenerative Erkrankungen
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913 1 _ |a DE-HGF
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914 1 _ |y 2018
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