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| 001 | 139754 | ||
| 005 | 20240321220658.0 | ||
| 024 | 7 | _ | |a 10.1016/j.cell.2017.11.048 |2 doi |
| 024 | 7 | _ | |a pmid:29290465 |2 pmid |
| 024 | 7 | _ | |a 0092-8674 |2 ISSN |
| 024 | 7 | _ | |a 1097-4172 |2 ISSN |
| 024 | 7 | _ | |a altmetric:31037804 |2 altmetric |
| 037 | _ | _ | |a DZNE-2020-06076 |
| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Ingold, Irina |b 0 |
| 245 | _ | _ | |a Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis. |
| 260 | _ | _ | |a New York, NY |c 2018 |b Elsevier |
| 264 | _ | 1 | |3 print |2 Crossref |b Elsevier BV |c 2018-01-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1710171774_27991 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Selenoproteins are rare proteins among all kingdoms of life containing the 21st amino acid, selenocysteine. Selenocysteine resembles cysteine, differing only by the substitution of selenium for sulfur. Yet the actual advantage of selenolate- versus thiolate-based catalysis has remained enigmatic, as most of the known selenoproteins also exist as cysteine-containing homologs. Here, we demonstrate that selenolate-based catalysis of the essential mammalian selenoprotein GPX4 is unexpectedly dispensable for normal embryogenesis. Yet the survival of a specific type of interneurons emerges to exclusively depend on selenocysteine-containing GPX4, thereby preventing fatal epileptic seizures. Mechanistically, selenocysteine utilization by GPX4 confers exquisite resistance to irreversible overoxidation as cells expressing a cysteine variant are highly sensitive toward peroxide-induced ferroptosis. Remarkably, concomitant deletion of all selenoproteins in Gpx4cys/cys cells revealed that selenoproteins are dispensable for cell viability provided partial GPX4 activity is retained. Conclusively, 200 years after its discovery, a specific and indispensable role for selenium is provided. |
| 536 | _ | _ | |a 342 - Disease Mechanisms and Model Systems (POF3-342) |0 G:(DE-HGF)POF3-342 |c POF3-342 |f POF III |x 0 |
| 542 | _ | _ | |i 2018-01-01 |2 Crossref |u https://www.elsevier.com/tdm/userlicense/1.0/ |
| 542 | _ | _ | |i 2019-01-25 |2 Crossref |u http://www.elsevier.com/open-access/userlicense/1.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 7 | |a Hydrogen Peroxide |0 BBX060AN9V |2 NLM Chemicals |
| 650 | _ | 7 | |a Phospholipid Hydroperoxide Glutathione Peroxidase |0 EC 1.11.1.12 |2 NLM Chemicals |
| 650 | _ | 7 | |a Glutathione Peroxidase |0 EC 1.11.1.9 |2 NLM Chemicals |
| 650 | _ | 7 | |a glutathione peroxidase 4, mouse |0 EC 1.11.1.9 |2 NLM Chemicals |
| 650 | _ | 7 | |a Selenium |0 H6241UJ22B |2 NLM Chemicals |
| 650 | _ | 2 | |a Animals |2 MeSH |
| 650 | _ | 2 | |a Apoptosis |2 MeSH |
| 650 | _ | 2 | |a Cell Survival |2 MeSH |
| 650 | _ | 2 | |a Cells, Cultured |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Glutathione Peroxidase: genetics |2 MeSH |
| 650 | _ | 2 | |a Glutathione Peroxidase: metabolism |2 MeSH |
| 650 | _ | 2 | |a HEK293 Cells |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Hydrogen Peroxide: toxicity |2 MeSH |
| 650 | _ | 2 | |a Interneurons: metabolism |2 MeSH |
| 650 | _ | 2 | |a Lipid Peroxidation |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Mice |2 MeSH |
| 650 | _ | 2 | |a Mice, Inbred C57BL |2 MeSH |
| 650 | _ | 2 | |a Phospholipid Hydroperoxide Glutathione Peroxidase |2 MeSH |
| 650 | _ | 2 | |a Seizures: etiology |2 MeSH |
| 650 | _ | 2 | |a Seizures: metabolism |2 MeSH |
| 650 | _ | 2 | |a Selenium: metabolism |2 MeSH |
| 700 | 1 | _ | |a Berndt, Carsten |b 1 |
| 700 | 1 | _ | |a Schmitt, Sabine |b 2 |
| 700 | 1 | _ | |a Doll, Sebastian |b 3 |
| 700 | 1 | _ | |a Poschmann, Gereon |b 4 |
| 700 | 1 | _ | |a Buday, Katalin |b 5 |
| 700 | 1 | _ | |a Roveri, Antonella |b 6 |
| 700 | 1 | _ | |a Peng, Xiaoxiao |b 7 |
| 700 | 1 | _ | |a Porto Freitas, Florencio |b 8 |
| 700 | 1 | _ | |a Seibt, Tobias |b 9 |
| 700 | 1 | _ | |a Mehr, Lisa |b 10 |
| 700 | 1 | _ | |a Aichler, Michaela |b 11 |
| 700 | 1 | _ | |a Walch, Axel |b 12 |
| 700 | 1 | _ | |a Lamp, Daniel |b 13 |
| 700 | 1 | _ | |a Jastroch, Martin |b 14 |
| 700 | 1 | _ | |a Miyamoto, Sayuri |b 15 |
| 700 | 1 | _ | |a Wurst, Wolfgang |0 P:(DE-2719)2000028 |b 16 |u dzne |
| 700 | 1 | _ | |a Ursini, Fulvio |b 17 |
| 700 | 1 | _ | |a Arnér, Elias S J |b 18 |
| 700 | 1 | _ | |a Fradejas-Villar, Noelia |b 19 |
| 700 | 1 | _ | |a Schweizer, Ulrich |b 20 |
| 700 | 1 | _ | |a Zischka, Hans |b 21 |
| 700 | 1 | _ | |a Friedmann Angeli, José Pedro |b 22 |
| 700 | 1 | _ | |a Conrad, Marcus |0 P:(DE-HGF)0 |b 23 |e Corresponding author |
| 773 | 1 | 8 | |a 10.1016/j.cell.2017.11.048 |b : Elsevier BV, 2018-01-01 |n 3 |p 409-422.e21 |3 journal-article |2 Crossref |t Cell |v 172 |y 2018 |x 0092-8674 |
| 773 | _ | _ | |a 10.1016/j.cell.2017.11.048 |g Vol. 172, no. 3, p. 409 - 422.e21 |0 PERI:(DE-600)2001951-8 |n 3 |q 172:3<409 - 422.e21 |p 409-422.e21 |t Cell |v 172 |y 2018 |x 0092-8674 |
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