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000139768 041__ $$aEnglish
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000139768 1001_ $$ade Boni, Laura$$b0
000139768 245__ $$aDNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling.
000139768 260__ $$a[S.l.]$$bBioMed Central$$c2018
000139768 264_1 $$2Crossref$$3online$$bSpringer Science and Business Media LLC$$c2018-01-29
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000139768 520__ $$aGenetic predisposition and epigenetic alterations are both considered to contribute to sporadic neurodegenerative diseases (NDDs) such as Parkinson's disease (PD). Since cell reprogramming and the generation of induced pluripotent stem cells (iPSCs) are themselves associated with major epigenetic remodeling, it remains unclear to what extent iPSC-derived neurons lend themselves to model epigenetic disease-associated changes. A key question to be addressed in this context is whether iPSC-derived neurons exhibit epigenetic signatures typically observed in neurons derived from non-reprogrammed human embryonic stem cells (hESCs).Here, we compare mature neurons derived from hESC and isogenic human iPSC generated from hESC-derived neural stem cells. Genome-wide 450 K-based DNA methylation and HT12v4 gene array expression analyses were complemented by a deep analysis of selected genes known to be involved in NDD. Our studies show that DNA methylation and gene expression patterns of isogenic hESC- and iPSC-derived neurons are markedly preserved on a genome-wide and single gene level.Overall, iPSC-derived neurons exhibit similar DNA methylation patterns compared to isogenic hESC-derived neurons. Further studies will be required to explore whether the epigenetic patterns observed in iPSC-derived neurons correspond to those detectable in native brain neurons.
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000139768 650_7 $$2NLM Chemicals$$aSNCA protein, human
000139768 650_7 $$2NLM Chemicals$$aalpha-Synuclein
000139768 650_2 $$2MeSH$$aCell Differentiation
000139768 650_2 $$2MeSH$$aCells, Cultured
000139768 650_2 $$2MeSH$$aDNA Methylation
000139768 650_2 $$2MeSH$$aEpigenesis, Genetic
000139768 650_2 $$2MeSH$$aGene Expression Profiling
000139768 650_2 $$2MeSH$$aHuman Embryonic Stem Cells: chemistry
000139768 650_2 $$2MeSH$$aHuman Embryonic Stem Cells: cytology
000139768 650_2 $$2MeSH$$aHumans
000139768 650_2 $$2MeSH$$aInduced Pluripotent Stem Cells: chemistry
000139768 650_2 $$2MeSH$$aInduced Pluripotent Stem Cells: cytology
000139768 650_2 $$2MeSH$$aNeurons: chemistry
000139768 650_2 $$2MeSH$$aOligonucleotide Array Sequence Analysis
000139768 650_2 $$2MeSH$$aSequence Analysis, DNA
000139768 650_2 $$2MeSH$$aalpha-Synuclein: genetics
000139768 7001_ $$aGasparoni, Gilles$$b1
000139768 7001_ $$aHaubenreich, Carolin$$b2
000139768 7001_ $$aTierling, Sascha$$b3
000139768 7001_ $$0P:(DE-2719)2810444$$aSchmitt, Ina$$b4$$udzne
000139768 7001_ $$0P:(DE-2719)9000249$$aPeitz, Michael$$b5$$udzne
000139768 7001_ $$aKoch, Philipp$$b6
000139768 7001_ $$0P:(DE-HGF)0$$aWalter, Jörn$$b7$$eCorresponding author
000139768 7001_ $$0P:(DE-2719)2000056$$aWüllner, Ullrich$$b8$$udzne
000139768 7001_ $$0P:(DE-HGF)0$$aBrüstle, Oliver$$b9
000139768 77318 $$2Crossref$$3journal-article$$a10.1186/s13148-018-0440-0$$b : Springer Science and Business Media LLC, 2018-01-29$$n1$$p13$$tClinical Epigenetics$$v10$$x1868-7075$$y2018
000139768 773__ $$0PERI:(DE-600)2553921-8$$a10.1186/s13148-018-0440-0$$gVol. 10, no. 1, p. 13$$n1$$p13$$q10:1<13$$tClinical epigenetics$$v10$$x1868-7075$$y2018
000139768 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5789607
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