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000139801 041__ $$aEnglish
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000139801 1001_ $$0P:(DE-2719)2812186$$aLerche, Stefanie$$b0$$eFirst author$$udzne
000139801 245__ $$aEffect of physical activity on cognitive flexibility, depression and RBD in healthy elderly.
000139801 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2018
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000139801 520__ $$aThe prevalence of Alzheimer's disease and Parkinson's disease increases with the raising number of elderly, which will be a challenging situation for the healthcare systems and society in the future. There is evidence that there are modifiable risk-factors e.g. physical activity for these diseases. Here, we study the interaction between sports inactivity with prodromal markers for neurodegeneration.We investigated 667 neurologically healthy individuals cross-sectional and a subgroup longitudinal over six years. Participants were stratified by their weekly sports activity. Prodromal markers (depression and REM sleep behaviour disorder (RBD)) as well as single and dual-tasking parameters and cognitive parameters were compared between the groups.At baseline, sports activity was associated with lower BDI scores, lower occurrence of depressive syndrome and RBD, compared to sports inactivity. Further, active participants were faster in cognitive tasks associated with working memory and attention (Trail Making test part-A; TMT-B, ΔTMT-B-A) and better in gait and cognition parameters (single tasks and dual tasks) but not with overall cognition as measured with the MMSE. The association between physical inactivity and depression as well as TMT was present after six years.We found that sports activity has a positive effect on cognitive flexibility, depressive symptoms and sleep which are all signs for a possible ongoing neurodegenerative process. Therefore, our results strengthen the potential role of sports activity as a positive disease modifier.
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000139801 650_7 $$2NLM Chemicals$$aBiomarkers
000139801 650_2 $$2MeSH$$aAged
000139801 650_2 $$2MeSH$$aAging: physiology
000139801 650_2 $$2MeSH$$aAging: psychology
000139801 650_2 $$2MeSH$$aBiomarkers
000139801 650_2 $$2MeSH$$aCognition: physiology
000139801 650_2 $$2MeSH$$aCross-Sectional Studies
000139801 650_2 $$2MeSH$$aDepression: epidemiology
000139801 650_2 $$2MeSH$$aDepression: psychology
000139801 650_2 $$2MeSH$$aExercise: physiology
000139801 650_2 $$2MeSH$$aFemale
000139801 650_2 $$2MeSH$$aHumans
000139801 650_2 $$2MeSH$$aLongitudinal Studies
000139801 650_2 $$2MeSH$$aMale
000139801 650_2 $$2MeSH$$aMemory, Short-Term
000139801 650_2 $$2MeSH$$aMiddle Aged
000139801 650_2 $$2MeSH$$aProspective Studies
000139801 650_2 $$2MeSH$$aPsychomotor Performance: physiology
000139801 650_2 $$2MeSH$$aREM Sleep Behavior Disorder: epidemiology
000139801 650_2 $$2MeSH$$aREM Sleep Behavior Disorder: psychology
000139801 650_2 $$2MeSH$$aRisk Factors
000139801 650_2 $$2MeSH$$aSports: physiology
000139801 650_2 $$2MeSH$$aSports: psychology
000139801 650_2 $$2MeSH$$aTrail Making Test
000139801 7001_ $$0P:(DE-2719)9000109$$aGutfreund, Alexandra$$b1$$udzne
000139801 7001_ $$0P:(DE-2719)2811916$$aBrockmann, Kathrin$$b2$$udzne
000139801 7001_ $$0P:(DE-HGF)0$$aHobert, Markus A$$b3
000139801 7001_ $$0P:(DE-2719)2812736$$aWurster, Isabel$$b4$$udzne
000139801 7001_ $$0P:(DE-2719)2811825$$aSünkel, Ulrike$$b5$$udzne
000139801 7001_ $$0P:(DE-HGF)0$$aEschweiler, Gerhard W$$b6
000139801 7001_ $$0P:(DE-HGF)0$$aMetzger, Florian G$$b7
000139801 7001_ $$0P:(DE-HGF)0$$aMaetzler, Walter$$b8
000139801 7001_ $$0P:(DE-HGF)0$$aBerg, Daniela$$b9
000139801 77318 $$2Crossref$$3journal-article$$a10.1016/j.clineuro.2018.01.008$$b : Elsevier BV, 2018-02-01$$p88-93$$tClinical Neurology and Neurosurgery$$v165$$x0303-8467$$y2018
000139801 773__ $$0PERI:(DE-600)2004613-3$$a10.1016/j.clineuro.2018.01.008$$gVol. 165, p. 88 - 93$$p88-93$$q165<88 - 93$$tClinical neurology and neurosurgery$$v165$$x0303-8467$$y2018
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