TY  - JOUR
AU  - Lerche, Stefanie
AU  - Gutfreund, Alexandra
AU  - Brockmann, Kathrin
AU  - Hobert, Markus A
AU  - Wurster, Isabel
AU  - Sünkel, Ulrike
AU  - Eschweiler, Gerhard W
AU  - Metzger, Florian G
AU  - Maetzler, Walter
AU  - Berg, Daniela
TI  - Effect of physical activity on cognitive flexibility, depression and RBD in healthy elderly.
JO  - Clinical neurology and neurosurgery
VL  - 165
SN  - 0303-8467
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - DZNE-2020-06123
SP  - 88-93
PY  - 2018
AB  - The prevalence of Alzheimer's disease and Parkinson's disease increases with the raising number of elderly, which will be a challenging situation for the healthcare systems and society in the future. There is evidence that there are modifiable risk-factors e.g. physical activity for these diseases. Here, we study the interaction between sports inactivity with prodromal markers for neurodegeneration.We investigated 667 neurologically healthy individuals cross-sectional and a subgroup longitudinal over six years. Participants were stratified by their weekly sports activity. Prodromal markers (depression and REM sleep behaviour disorder (RBD)) as well as single and dual-tasking parameters and cognitive parameters were compared between the groups.At baseline, sports activity was associated with lower BDI scores, lower occurrence of depressive syndrome and RBD, compared to sports inactivity. Further, active participants were faster in cognitive tasks associated with working memory and attention (Trail Making test part-A; TMT-B, ΔTMT-B-A) and better in gait and cognition parameters (single tasks and dual tasks) but not with overall cognition as measured with the MMSE. The association between physical inactivity and depression as well as TMT was present after six years.We found that sports activity has a positive effect on cognitive flexibility, depressive symptoms and sleep which are all signs for a possible ongoing neurodegenerative process. Therefore, our results strengthen the potential role of sports activity as a positive disease modifier.
KW  - Aged
KW  - Aging: physiology
KW  - Aging: psychology
KW  - Biomarkers
KW  - Cognition: physiology
KW  - Cross-Sectional Studies
KW  - Depression: epidemiology
KW  - Depression: psychology
KW  - Exercise: physiology
KW  - Female
KW  - Humans
KW  - Longitudinal Studies
KW  - Male
KW  - Memory, Short-Term
KW  - Middle Aged
KW  - Prospective Studies
KW  - Psychomotor Performance: physiology
KW  - REM Sleep Behavior Disorder: epidemiology
KW  - REM Sleep Behavior Disorder: psychology
KW  - Risk Factors
KW  - Sports: physiology
KW  - Sports: psychology
KW  - Trail Making Test
KW  - Biomarkers (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29331872
DO  - DOI:10.1016/j.clineuro.2018.01.008
UR  - https://pub.dzne.de/record/139801
ER  -