% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Lerche:139801,
      author       = {Lerche, Stefanie and Gutfreund, Alexandra and Brockmann,
                      Kathrin and Hobert, Markus A and Wurster, Isabel and
                      Sünkel, Ulrike and Eschweiler, Gerhard W and Metzger,
                      Florian G and Maetzler, Walter and Berg, Daniela},
      title        = {{E}ffect of physical activity on cognitive flexibility,
                      depression and {RBD} in healthy elderly.},
      journal      = {Clinical neurology and neurosurgery},
      volume       = {165},
      issn         = {0303-8467},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-06123},
      pages        = {88-93},
      year         = {2018},
      abstract     = {The prevalence of Alzheimer's disease and Parkinson's
                      disease increases with the raising number of elderly, which
                      will be a challenging situation for the healthcare systems
                      and society in the future. There is evidence that there are
                      modifiable risk-factors e.g. physical activity for these
                      diseases. Here, we study the interaction between sports
                      inactivity with prodromal markers for neurodegeneration.We
                      investigated 667 neurologically healthy individuals
                      cross-sectional and a subgroup longitudinal over six years.
                      Participants were stratified by their weekly sports
                      activity. Prodromal markers (depression and REM sleep
                      behaviour disorder (RBD)) as well as single and dual-tasking
                      parameters and cognitive parameters were compared between
                      the groups.At baseline, sports activity was associated with
                      lower BDI scores, lower occurrence of depressive syndrome
                      and RBD, compared to sports inactivity. Further, active
                      participants were faster in cognitive tasks associated with
                      working memory and attention (Trail Making test part-A;
                      TMT-B, ΔTMT-B-A) and better in gait and cognition
                      parameters (single tasks and dual tasks) but not with
                      overall cognition as measured with the MMSE. The association
                      between physical inactivity and depression as well as TMT
                      was present after six years.We found that sports activity
                      has a positive effect on cognitive flexibility, depressive
                      symptoms and sleep which are all signs for a possible
                      ongoing neurodegenerative process. Therefore, our results
                      strengthen the potential role of sports activity as a
                      positive disease modifier.},
      keywords     = {Aged / Aging: physiology / Aging: psychology / Biomarkers /
                      Cognition: physiology / Cross-Sectional Studies /
                      Depression: epidemiology / Depression: psychology /
                      Exercise: physiology / Female / Humans / Longitudinal
                      Studies / Male / Memory, Short-Term / Middle Aged /
                      Prospective Studies / Psychomotor Performance: physiology /
                      REM Sleep Behavior Disorder: epidemiology / REM Sleep
                      Behavior Disorder: psychology / Risk Factors / Sports:
                      physiology / Sports: psychology / Trail Making Test /
                      Biomarkers (NLM Chemicals)},
      cin          = {Tübingen common / Ext UKT-Trend / AG Gasser / Biobanking
                      Facility Tübingen / Core ICRU},
      ddc          = {610},
      cid          = {I:(DE-2719)6000018 / I:(DE-2719)5000056 /
                      I:(DE-2719)1210000 / I:(DE-2719)1240004 /
                      I:(DE-2719)1240005},
      pnm          = {345 - Population Studies and Genetics (POF3-345)},
      pid          = {G:(DE-HGF)POF3-345},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29331872},
      doi          = {10.1016/j.clineuro.2018.01.008},
      url          = {https://pub.dzne.de/record/139801},
}