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000139807 1001_ $$0P:(DE-2719)9000071$$aFehlinger, Andrea$$b0$$eFirst author$$udzne
000139807 245__ $$aPrion strains depend on different endocytic routes for productive infection.
000139807 260__ $$a[London]$$bMacmillan Publishers Limited, part of Springer Nature$$c2017
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000139807 520__ $$aPrions are unconventional agents composed of misfolded prion protein that cause fatal neurodegenerative diseases in mammals. Prion strains induce specific neuropathological changes in selected brain areas. The mechanism of strain-specific cell tropism is unknown. We hypothesised that prion strains rely on different endocytic routes to invade and replicate within their target cells. Using prion permissive cells, we determined how impairment of endocytosis affects productive infection by prion strains 22L and RML. We demonstrate that early and late stages of prion infection are differentially sensitive to perturbation of clathrin- and caveolin-mediated endocytosis. Manipulation of canonical endocytic pathways only slightly influenced prion uptake. However, blocking the same routes had drastic strain-specific consequences on the establishment of infection. Our data argue that prion strains use different endocytic pathways for infection and suggest that cell type-dependent differences in prion uptake could contribute to host cell tropism.
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000139807 650_7 $$2NLM Chemicals$$aCav1 protein, mouse
000139807 650_7 $$2NLM Chemicals$$aCaveolin 1
000139807 650_7 $$2NLM Chemicals$$aPrPSc Proteins
000139807 650_2 $$2MeSH$$aAnimals
000139807 650_2 $$2MeSH$$aBiological Transport
000139807 650_2 $$2MeSH$$aCaveolin 1: metabolism
000139807 650_2 $$2MeSH$$aCell Line
000139807 650_2 $$2MeSH$$aCell Membrane: metabolism
000139807 650_2 $$2MeSH$$aEndocytosis
000139807 650_2 $$2MeSH$$aMice
000139807 650_2 $$2MeSH$$aPrPSc Proteins: metabolism
000139807 650_2 $$2MeSH$$aPrPSc Proteins: pathogenicity
000139807 650_2 $$2MeSH$$aPrion Diseases: metabolism
000139807 7001_ $$0P:(DE-2719)2630412$$aWolf, Hanna$$b1$$udzne
000139807 7001_ $$0P:(DE-2719)2810581$$aHossinger, André$$b2$$udzne
000139807 7001_ $$0P:(DE-2719)2810519$$aDürnberger, Yvonne$$b3$$udzne
000139807 7001_ $$0P:(DE-2719)2811201$$aPleschka, Catharina$$b4$$udzne
000139807 7001_ $$0P:(DE-2719)2811067$$aRiemschoß, Katrin$$b5$$udzne
000139807 7001_ $$0P:(DE-2719)2810461$$aLiu, Shu$$b6$$udzne
000139807 7001_ $$aBester, Romina$$b7
000139807 7001_ $$0P:(DE-2719)2651099$$aPaulsen, Lydia$$b8$$udzne
000139807 7001_ $$aPriola, Suzette A$$b9
000139807 7001_ $$aGroschup, Martin H$$b10
000139807 7001_ $$aSchätzl, Hermann M$$b11
000139807 7001_ $$0P:(DE-2719)2481765$$aVorberg, Ina M$$b12$$eLast author$$udzne
000139807 77318 $$2Crossref$$3journal-article$$a10.1038/s41598-017-07260-2$$b : Springer Science and Business Media LLC, 2017-07-31$$n1$$p6923$$tScientific Reports$$v7$$x2045-2322$$y2017
000139807 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/s41598-017-07260-2$$gVol. 7, no. 1, p. 6923$$n1$$p6923$$q7:1<6923$$tScientific reports$$v7$$x2045-2322$$y2017
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