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000139813 0247_ $$2doi$$a10.1073/pnas.1712268115
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000139813 041__ $$aEnglish
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000139813 1001_ $$0P:(DE-2719)2811927$$aHämmerer, Dorothea$$b0$$eFirst author$$udzne
000139813 245__ $$aLocus coeruleus integrity in old age is selectively related to memories linked with salient negative events.
000139813 260__ $$aWashington, DC$$bNational Acad. of Sciences$$c2018
000139813 264_1 $$2Crossref$$3online$$bProceedings of the National Academy of Sciences$$c2018-02-12
000139813 264_1 $$2Crossref$$3print$$bProceedings of the National Academy of Sciences$$c2018-02-27
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000139813 520__ $$aThe locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity varies considerably across healthy older individuals, and is suggested to contribute to altered cognitive functions in aging. Here we test this hypothesis using an incidental memory task that is known to be susceptible to noradrenergic modulation. We used MRI neuromelanin (NM) imaging to assess LC structural integrity and pupillometry as a putative index of LC activation in both younger and older adults. We show that older adults with reduced structural LC integrity show poorer subsequent memory. This effect is more pronounced for emotionally negative events, in accord with a greater role for noradrenergic modulation in encoding salient or aversive events. In addition, we found that salient stimuli led to greater pupil diameters, consistent with increased LC activation during the encoding of such events. Our study presents novel evidence that a decrement in noradrenergic modulation impacts on specific components of cognition in healthy older adults. The findings provide a strong motivation for further investigation of the effects of altered LC integrity in pathological aging.
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000139813 650_2 $$2MeSH$$aAdult
000139813 650_2 $$2MeSH$$aAged
000139813 650_2 $$2MeSH$$aAged, 80 and over
000139813 650_2 $$2MeSH$$aAging: physiology
000139813 650_2 $$2MeSH$$aHumans
000139813 650_2 $$2MeSH$$aLocus Coeruleus: physiology
000139813 650_2 $$2MeSH$$aMagnetic Resonance Imaging
000139813 650_2 $$2MeSH$$aMemory
000139813 650_2 $$2MeSH$$aYoung Adult
000139813 7001_ $$0P:(DE-HGF)0$$aCallaghan, Martina F$$b1
000139813 7001_ $$0P:(DE-HGF)0$$aHopkins, Alexandra$$b2
000139813 7001_ $$0P:(DE-HGF)0$$aKosciessa, Julian$$b3
000139813 7001_ $$0P:(DE-2719)2810555$$aBetts, Matthew$$b4$$udzne
000139813 7001_ $$0P:(DE-2719)2810750$$aCardenas-Blanco, Arturo$$b5$$udzne
000139813 7001_ $$0P:(DE-HGF)0$$aKanowski, Martin$$b6
000139813 7001_ $$0P:(DE-HGF)0$$aWeiskopf, Nikolaus$$b7
000139813 7001_ $$0P:(DE-HGF)0$$aDayan, Peter$$b8
000139813 7001_ $$0P:(DE-HGF)0$$aDolan, Raymond J$$b9
000139813 7001_ $$0P:(DE-2719)2000005$$aDüzel, Emrah$$b10$$eLast author$$udzne
000139813 77318 $$2Crossref$$3journal-article$$a10.1073/pnas.1712268115$$b : Proceedings of the National Academy of Sciences, 2018-02-12$$n9$$p2228-2233$$tProceedings of the National Academy of Sciences$$v115$$x0027-8424$$y2018
000139813 773__ $$0PERI:(DE-600)1461794-8$$a10.1073/pnas.1712268115$$gVol. 115, no. 9, p. 2228 - 2233$$n9$$p2228-2233$$q115:9<2228 - 2233$$tProceedings of the National Academy of Sciences of the United States of America$$v115$$x0027-8424$$y2018
000139813 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5834676
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