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@ARTICLE{Hmmerer:139813,
      author       = {Hämmerer, Dorothea and Callaghan, Martina F and Hopkins,
                      Alexandra and Kosciessa, Julian and Betts, Matthew and
                      Cardenas-Blanco, Arturo and Kanowski, Martin and Weiskopf,
                      Nikolaus and Dayan, Peter and Dolan, Raymond J and Düzel,
                      Emrah},
      title        = {{L}ocus coeruleus integrity in old age is selectively
                      related to memories linked with salient negative events.},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {115},
      number       = {9},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {DZNE-2020-06135},
      pages        = {2228-2233},
      year         = {2018},
      abstract     = {The locus coeruleus (LC) is the principal origin of
                      noradrenaline in the brain. LC integrity varies considerably
                      across healthy older individuals, and is suggested to
                      contribute to altered cognitive functions in aging. Here we
                      test this hypothesis using an incidental memory task that is
                      known to be susceptible to noradrenergic modulation. We used
                      MRI neuromelanin (NM) imaging to assess LC structural
                      integrity and pupillometry as a putative index of LC
                      activation in both younger and older adults. We show that
                      older adults with reduced structural LC integrity show
                      poorer subsequent memory. This effect is more pronounced for
                      emotionally negative events, in accord with a greater role
                      for noradrenergic modulation in encoding salient or aversive
                      events. In addition, we found that salient stimuli led to
                      greater pupil diameters, consistent with increased LC
                      activation during the encoding of such events. Our study
                      presents novel evidence that a decrement in noradrenergic
                      modulation impacts on specific components of cognition in
                      healthy older adults. The findings provide a strong
                      motivation for further investigation of the effects of
                      altered LC integrity in pathological aging.},
      keywords     = {Adult / Aged / Aged, 80 and over / Aging: physiology /
                      Humans / Locus Coeruleus: physiology / Magnetic Resonance
                      Imaging / Memory / Young Adult},
      cin          = {AG Speck / AG Düzel},
      ddc          = {500},
      cid          = {I:(DE-2719)1340009 / I:(DE-2719)5000006},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29440429},
      pmc          = {pmc:PMC5834676},
      doi          = {10.1073/pnas.1712268115},
      url          = {https://pub.dzne.de/record/139813},
}