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024 7 _ |a 10.3389/fnagi.2018.00045
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041 _ _ |a English
082 _ _ |a 610
100 1 _ |a Schönecker, Sonja
|b 0
245 _ _ |a Atrophy in the Thalamus But Not Cerebellum Is Specific for C9orf72 FTD and ALS Patients - An Atlas-Based Volumetric MRI Study.
260 _ _ |a Lausanne
|c 2018
|b Frontiers Research Foundation
264 _ 1 |3 online
|2 Crossref
|b Frontiers Media SA
|c 2018-03-15
336 7 _ |a article
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336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a Journal Article
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520 _ _ |a Background: The neuropathology of patients with frontotemporal dementia (FTD) or amyotrophic lateral sclerosis (ALS) due to a C9orf72 mutation is characterized by two distinct types of characteristic protein depositions containing either TDP-43 or so-called dipeptide repeat proteins that extend beyond frontal and temporal regions. Thalamus and cerebellum seem to be preferentially affected by the dipeptide repeat pathology unique to C9orf72 mutation carriers. Objective: This study aimed to determine if mutation carriers showed an enhanced degree of thalamic and cerebellar atrophy compared to sporadic patients or healthy controls. Methods: Atlas-based volumetry was performed in 13 affected C9orf72 FTD, ALS and FTD/ALS patients, 45 sporadic FTD and FTD/ALS patients and 19 healthy controls. Volumes and laterality indices showing significant differences between mutation carriers and sporadic patients were subjected to binary logistic regression to determine the best predictor of mutation carrier status. Results: Compared to sporadic patients, mutation carriers showed a significant volume reduction of the thalamus, which was most striking in the occipital, temporal and prefrontal subregion of the thalamus. Disease severity measured by mini mental status examination (MMSE) and FTD modified Clinical Dementia Rating Scale Sum of Boxes (FTD-CDR-SOB) significantly correlated with volume reduction in the aforementioned thalamic subregions. No significant atrophy of cerebellar regions could be detected. A logistic regression model using the volume of the prefrontal and the laterality index of the occipital subregion of the thalamus as predictor variables resulted in an area under the curve (AUC) of 0.88 while a model using overall thalamic volume still resulted in an AUC of 0.82. Conclusion: Our data show that thalamic atrophy in C9orf72 mutation carriers goes beyond the expected atrophy in the prefrontal and temporal subregion and is in good agreement with the cortical atrophy pattern described in C9orf72 mutation carriers, indicating a retrograde degeneration of functionally connected regions. Clinical relevance of the detected thalamic atrophy is illustrated by a correlation with disease severity. Furthermore, the findings suggest MRI volumetry of the thalamus to be of high predictive value in differentiating C9orf72 mutation carriers from patients with sporadic FTD.
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700 1 _ |a Schroeter, Matthias L
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700 1 _ |a Jahn, Holger
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700 1 _ |a Boeckh-Behrens, Tobias
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700 1 _ |a Roßmeier, Carola
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700 1 _ |a Albrecht, Franziska
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700 1 _ |a Schümberg, Katharina
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700 1 _ |a Bisenius, Sandrine
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999 C 5 |y 2008
|2 Crossref
|o Alelú-Paz 2008
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00401-011-0911-2
|2 Crossref
|o 10.1007/s00401-011-0911-2
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuron.2013.02.004
|2 Crossref
|o 10.1016/j.neuron.2013.02.004
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroimage.2007.07.007
|2 Crossref
|o 10.1016/j.neuroimage.2007.07.007
999 C 5 |9 -- missing cx lookup --
|a 10.1212/WNL.0b013e31829c5eee
|2 Crossref
|o 10.1212/WNL.0b013e31829c5eee
999 C 5 |9 -- missing cx lookup --
|a 10.1038/nn1075
|2 Crossref
|o 10.1038/nn1075
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.nicl.2016.02.008
|2 Crossref
|o 10.1016/j.nicl.2016.02.008
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/aws004
|2 Crossref
|o 10.1093/brain/aws004
999 C 5 |9 -- missing cx lookup --
|a 10.1136/jnnp.2009.204081
|2 Crossref
|o 10.1136/jnnp.2009.204081
999 C 5 |9 -- missing cx lookup --
|a 10.1080/146608200300079536
|2 Crossref
|o 10.1080/146608200300079536
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00429-015-1088-6
|2 Crossref
|o 10.1007/s00429-015-1088-6
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.tins.2013.04.010
|2 Crossref
|o 10.1016/j.tins.2013.04.010
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuron.2011.09.011
|2 Crossref
|o 10.1016/j.neuron.2011.09.011
999 C 5 |9 -- missing cx lookup --
|a 10.1176/appi.neuropsych.16090168
|2 Crossref
|o 10.1176/appi.neuropsych.16090168
999 C 5 |9 -- missing cx lookup --
|a 10.1176/ajp.152.5.704
|2 Crossref
|o 10.1176/ajp.152.5.704
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.nicl.2016.10.014
|2 Crossref
|o 10.1016/j.nicl.2016.10.014
999 C 5 |9 -- missing cx lookup --
|a 10.1002/hbm.21304
|2 Crossref
|o 10.1002/hbm.21304
999 C 5 |9 -- missing cx lookup --
|a 10.1371/journal.pone.0090814
|2 Crossref
|o 10.1371/journal.pone.0090814
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/123.4.816
|2 Crossref
|o 10.1093/brain/123.4.816
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00401-013-1192-8
|2 Crossref
|o 10.1007/s00401-013-1192-8
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.25815
|2 Crossref
|o 10.1002/mds.25815
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroimage.2009.10.066
|2 Crossref
|o 10.1016/j.neuroimage.2009.10.066
999 C 5 |9 -- missing cx lookup --
|a 10.1002/mds.26715
|2 Crossref
|o 10.1002/mds.26715
999 C 5 |9 -- missing cx lookup --
|a 10.1136/jnnp-2012-303507
|2 Crossref
|o 10.1136/jnnp-2012-303507
999 C 5 |9 -- missing cx lookup --
|a 10.1093/cercor/bhh105
|2 Crossref
|o 10.1093/cercor/bhh105
999 C 5 |9 -- missing cx lookup --
|a 10.3174/ajnr.A2514
|2 Crossref
|o 10.3174/ajnr.A2514
999 C 5 |9 -- missing cx lookup --
|a 10.1136/jnnp-2011-301883
|2 Crossref
|o 10.1136/jnnp-2011-301883
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awn234
|2 Crossref
|o 10.1093/brain/awn234
999 C 5 |9 -- missing cx lookup --
|a 10.1093/cercor/bhp135
|2 Crossref
|o 10.1093/cercor/bhp135
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awu248
|2 Crossref
|o 10.1093/brain/awu248
999 C 5 |9 -- missing cx lookup --
|a 10.1212/WNL.59.7.1077
|2 Crossref
|o 10.1212/WNL.59.7.1077
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awr361
|2 Crossref
|o 10.1093/brain/awr361
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00429-010-0265-x
|2 Crossref
|o 10.1007/s00429-010-0265-x
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00429-010-0262-0
|2 Crossref
|o 10.1007/s00429-010-0262-0
999 C 5 |9 -- missing cx lookup --
|a 10.1080/09720502.2010.10700699
|2 Crossref
|o 10.1080/09720502.2010.10700699
999 C 5 |9 -- missing cx lookup --
|a 10.3389/fnsys.2013.00037
|2 Crossref
|o 10.3389/fnsys.2013.00037
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00401-013-1189-3
|2 Crossref
|o 10.1007/s00401-013-1189-3
999 C 5 |9 -- missing cx lookup --
|a 10.1126/science.1232927
|2 Crossref
|o 10.1126/science.1232927
999 C 5 |9 -- missing cx lookup --
|a 10.1038/mp.2015.209
|2 Crossref
|o 10.1038/mp.2015.209
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.mri.2015.12.031
|2 Crossref
|o 10.1016/j.mri.2015.12.031
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00115-011-3261-3
|2 Crossref
|o 10.1007/s00115-011-3261-3
999 C 5 |9 -- missing cx lookup --
|a 10.1055/s-0033-1359316
|2 Crossref
|o 10.1055/s-0033-1359316
999 C 5 |9 -- missing cx lookup --
|a 10.1590/1980-57642015DN94000413
|2 Crossref
|o 10.1590/1980-57642015DN94000413
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/awr179
|2 Crossref
|o 10.1093/brain/awr179
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S1474-4422(14)70324-2
|2 Crossref
|o 10.1016/S1474-4422(14)70324-2
999 C 5 |9 -- missing cx lookup --
|a 10.1002/(SICI)1096-9861(19970317)379:3<313::AID-CNE1>3.0.CO;2-6
|2 Crossref
|o 10.1002/(SICI)1096-9861(19970317)379:3<313::AID-CNE1>3.0.CO;2-6
999 C 5 |9 -- missing cx lookup --
|a 10.1007/s00401-015-1450-z
|2 Crossref
|o 10.1007/s00401-015-1450-z
999 C 5 |9 -- missing cx lookup --
|a 10.1186/s12883-016-0647-7
|2 Crossref
|o 10.1186/s12883-016-0647-7
999 C 5 |9 -- missing cx lookup --
|a 10.1001/archneurol.2007.38
|2 Crossref
|o 10.1001/archneurol.2007.38
999 C 5 |9 -- missing cx lookup --
|a 10.1523/JNEUROSCI.5587-06.2007
|2 Crossref
|o 10.1523/JNEUROSCI.5587-06.2007
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.mri.2007.10.010
|2 Crossref
|o 10.1016/j.mri.2007.10.010
999 C 5 |9 -- missing cx lookup --
|a 10.1212/WNL.0b013e318268452e
|2 Crossref
|o 10.1212/WNL.0b013e318268452e
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neuroimage.2007.09.031
|2 Crossref
|o 10.1016/j.neuroimage.2007.09.031
999 C 5 |y 2009
|2 Crossref
|o Šimundić 2009
999 C 5 |9 -- missing cx lookup --
|a 10.3109/21678421.2015.1074700
|2 Crossref
|o 10.3109/21678421.2015.1074700
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.cortex.2009.11.008
|2 Crossref
|o 10.1016/j.cortex.2009.11.008
999 C 5 |9 -- missing cx lookup --
|a 10.1016/j.neubiorev.2011.05.003
|2 Crossref
|o 10.1016/j.neubiorev.2011.05.003
999 C 5 |9 -- missing cx lookup --
|a 10.1093/brain/aws001
|2 Crossref
|o 10.1093/brain/aws001
999 C 5 |9 -- missing cx lookup --
|a 10.1186/alzrt148
|2 Crossref
|o 10.1186/alzrt148
999 C 5 |9 -- missing cx lookup --
|a 10.1016/S0006-3223(00)00826-X
|2 Crossref
|o 10.1016/S0006-3223(00)00826-X


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Marc 21