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@ARTICLE{Berron:139871,
      author       = {Berron, David and Neumann, Katja and Maaß, Anne and
                      Schütze, Hartmut and Fliessbach, Klaus and Kiven, Verena
                      and Jessen, Frank and Sauvage, Magdalena and Kumaran,
                      Dharshan and Düzel, Emrah},
      title        = {{A}ge-related functional changes in domain-specific medial
                      temporal lobe pathways.},
      journal      = {Neurobiology of aging},
      volume       = {65},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {DZNE-2020-06193},
      pages        = {86-97},
      year         = {2018},
      abstract     = {There is now converging evidence from studies in animals
                      and humans that the medial temporal lobes (MTLs) harbor
                      anatomically distinct processing pathways for object and
                      scene information. Recent functional magnetic resonance
                      imaging studies in humans suggest that this domain-specific
                      organization may be associated with a functional preference
                      of the anterior-lateral part of the entorhinal cortex
                      (alErC) for objects and the posterior-medial entorhinal
                      cortex (pmErC) for scenes. As MTL subregions are
                      differentially affected by aging and neurodegenerative
                      diseases, the question was raised whether aging may affect
                      the 2 pathways differentially. To address this possibility,
                      we developed a paradigm that allows the investigation of
                      object memory and scene memory in a mnemonic discrimination
                      task. A group of young (n = 43) and healthy older subjects
                      (n = 44) underwent functional magnetic resonance imaging
                      recordings during this novel task, while they were asked to
                      discriminate exact repetitions of object and scene stimuli
                      from novel stimuli that were similar but modified versions
                      of the original stimuli ('lures'). We used structural
                      magnetic resonance images to manually segment anatomical
                      components of the MTL including alErC and pmErC and used
                      these segmented regions to analyze domain specificity of
                      functional activity. Across the entire sample, object
                      processing was associated with activation of the perirhinal
                      cortex (PrC) and alErC, whereas for scene processing,
                      activation was more predominant in the parahippocampal
                      cortex and pmErC. Functional activity related to mnemonic
                      discrimination of object and scene lures from exact
                      repetitions was found to overlap between processing pathways
                      and suggests that while the PrC-alErC pathway was more
                      involved in object discrimination, both pathways were
                      involved in the discrimination of similar scenes. Older
                      adults were behaviorally less accurate than young adults in
                      discriminating similar lures from exact repetitions, but
                      this reduction was equivalent in both domains. However, this
                      was accompanied by significantly reduced domain-specific
                      activity in PrC in older adults compared to what was
                      observed in the young. Furthermore, this reduced
                      domain-specific activity was associated to worse performance
                      in object mnemonic discrimination in older adults. Taken
                      together, we show the fine-grained functional organization
                      of the MTL into domain-specific pathways for objects and
                      scenes and their mnemonic discrimination and further provide
                      evidence that aging might affect these pathways in a
                      differential fashion. Future experiments will elucidate
                      whether the 2 pathways are differentially affected in early
                      stages of Alzheimer's disease in relation to amyloid or tau
                      pathology.},
      keywords     = {Adult / Aged / Entorhinal Cortex: diagnostic imaging /
                      Entorhinal Cortex: pathology / Entorhinal Cortex: physiology
                      / Female / Healthy Aging: pathology / Healthy Aging:
                      physiology / Hippocampus: diagnostic imaging / Hippocampus:
                      pathology / Hippocampus: physiology / Humans / Magnetic
                      Resonance Imaging / Male / Middle Aged / Neural Pathways:
                      diagnostic imaging / Neural Pathways: pathology / Neural
                      Pathways: physiology / Perirhinal Cortex: diagnostic imaging
                      / Perirhinal Cortex: pathology / Perirhinal Cortex:
                      physiology / Temporal Lobe: diagnostic imaging / Temporal
                      Lobe: pathology / Temporal Lobe: physiology / Young Adult},
      cin          = {AG Düzel / AG Speck / AG Jessen / Delcode},
      ddc          = {610},
      cid          = {I:(DE-2719)5000006 / I:(DE-2719)1340009 /
                      I:(DE-2719)1011102 / I:(DE-2719)5000034},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      experiment   = {EXP:(DE-2719)DELCODE-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29454154},
      doi          = {10.1016/j.neurobiolaging.2017.12.030},
      url          = {https://pub.dzne.de/record/139871},
}