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000139887 041__ $$aEnglish
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000139887 1001_ $$0P:(DE-2719)2810620$$aStangl, Matthias$$b0$$eFirst author$$udzne
000139887 245__ $$aCompromised Grid-Cell-like Representations in Old Age as a Key Mechanism to Explain Age-Related Navigational Deficits.
000139887 260__ $$aLondon$$bCurrent Biology Ltd.$$c2018
000139887 264_1 $$2Crossref$$3print$$bElsevier BV$$c2018-04-01
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000139887 520__ $$aA progressive loss of navigational abilities in old age has been observed in numerous studies, but we have only limited understanding of the neural mechanisms underlying this decline [1]. A central component of the brain's navigation circuit are grid cells in entorhinal cortex [2], largely thought to support intrinsic self-motion-related computations, such as path integration (i.e., keeping track of one's position by integrating self-motion cues) [3-6]. Given that entorhinal cortex is particularly vulnerable to neurodegenerative processes during aging and Alzheimer's disease [7-14], deficits in grid cell function could be a key mechanism to explain age-related navigational decline. To test this hypothesis, we conducted two experiments in healthy young and older adults. First, in an fMRI experiment, we found significantly reduced grid-cell-like representations in entorhinal cortex of older adults. Second, in a behavioral path integration experiment, older adults showed deficits in computations of self-position during path integration based on body-based or visual self-motion cues. Most strikingly, we found that these path integration deficits in older adults could be explained by their individual magnitudes of grid-cell-like representations, as reduced grid-cell-like representations were associated with larger path integration errors. Together, these results show that grid-cell-like representations in entorhinal cortex are compromised in healthy aging. Furthermore, the association between grid-cell-like representations and path integration performance in old age supports the notion that grid cells underlie path integration processes. We therefore conclude that impaired grid cell function may play a key role in age-related decline of specific higher-order cognitive functions, such as spatial navigation.
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000139887 542__ $$2Crossref$$i2018-04-01$$uhttps://www.elsevier.com/tdm/userlicense/1.0/
000139887 542__ $$2Crossref$$i2018-02-20$$uhttp://creativecommons.org/licenses/by/4.0/
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000139887 650_2 $$2MeSH$$aAdult
000139887 650_2 $$2MeSH$$aAged
000139887 650_2 $$2MeSH$$aAging: pathology
000139887 650_2 $$2MeSH$$aCognition: physiology
000139887 650_2 $$2MeSH$$aEntorhinal Cortex: physiology
000139887 650_2 $$2MeSH$$aFemale
000139887 650_2 $$2MeSH$$aGrid Cells: physiology
000139887 650_2 $$2MeSH$$aHumans
000139887 650_2 $$2MeSH$$aMale
000139887 650_2 $$2MeSH$$aSpatial Memory: physiology
000139887 650_2 $$2MeSH$$aSpatial Navigation: physiology
000139887 7001_ $$0P:(DE-2719)2810753$$aAchtzehn, Johannes$$b1$$udzne
000139887 7001_ $$0P:(DE-2719)2811995$$aHuber, Karin$$b2$$udzne
000139887 7001_ $$0P:(DE-2719)2811566$$aDietrich, Caroline$$b3$$udzne
000139887 7001_ $$0P:(DE-HGF)0$$aTempelmann, Claus$$b4
000139887 7001_ $$0P:(DE-2719)2810583$$aWolbers, Thomas$$b5$$eLast author$$udzne
000139887 77318 $$2Crossref$$3journal-article$$a10.1016/j.cub.2018.02.038$$b : Elsevier BV, 2018-04-01$$n7$$p1108-1115.e6$$tCurrent Biology$$v28$$x0960-9822$$y2018
000139887 773__ $$0PERI:(DE-600)2019214-9$$a10.1016/j.cub.2018.02.038$$gVol. 28, no. 7, p. 1108 - 1115.e6$$n7$$p1108-1115.e6$$q28:7<1108 - 1115.e6$$tCurrent biology$$v28$$x0960-9822$$y2018
000139887 8567_ $$2Pubmed Central$$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887108
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