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@ARTICLE{Stangl:139887,
      author       = {Stangl, Matthias and Achtzehn, Johannes and Huber, Karin
                      and Dietrich, Caroline and Tempelmann, Claus and Wolbers,
                      Thomas},
      title        = {{C}ompromised {G}rid-{C}ell-like {R}epresentations in {O}ld
                      {A}ge as a {K}ey {M}echanism to {E}xplain {A}ge-{R}elated
                      {N}avigational {D}eficits.},
      journal      = {Current biology},
      volume       = {28},
      number       = {7},
      issn         = {0960-9822},
      address      = {London},
      publisher    = {Current Biology Ltd.},
      reportid     = {DZNE-2020-06209},
      pages        = {1108-1115.e6},
      year         = {2018},
      abstract     = {A progressive loss of navigational abilities in old age has
                      been observed in numerous studies, but we have only limited
                      understanding of the neural mechanisms underlying this
                      decline [1]. A central component of the brain's navigation
                      circuit are grid cells in entorhinal cortex [2], largely
                      thought to support intrinsic self-motion-related
                      computations, such as path integration (i.e., keeping track
                      of one's position by integrating self-motion cues) [3-6].
                      Given that entorhinal cortex is particularly vulnerable to
                      neurodegenerative processes during aging and Alzheimer's
                      disease [7-14], deficits in grid cell function could be a
                      key mechanism to explain age-related navigational decline.
                      To test this hypothesis, we conducted two experiments
                      in healthy young and older adults. First, in an fMRI
                      experiment, we found significantly reduced grid-cell-like
                      representations in entorhinal cortex of older adults.
                      Second, in a behavioral path integration experiment, older
                      adults showed deficits in computations of self-position
                      during path integration based on body-based or visual
                      self-motion cues. Most strikingly, we found that these path
                      integration deficits in older adults could be explained by
                      their individual magnitudes of
                      grid-cell-like representations, as reduced grid-cell-like
                      representations were associated with larger path integration
                      errors. Together, these results show that grid-cell-like
                      representations in entorhinal cortex are compromised in
                      healthy aging. Furthermore, the association between
                      grid-cell-like representations and path integration
                      performance in old age supports the notion that grid cells
                      underlie path integration processes. We therefore conclude
                      that impaired grid cell function may play a key role in
                      age-related decline of specific higher-order cognitive
                      functions, such as spatial navigation.},
      keywords     = {Adult / Aged / Aging: pathology / Cognition: physiology /
                      Entorhinal Cortex: physiology / Female / Grid Cells:
                      physiology / Humans / Male / Spatial Memory: physiology /
                      Spatial Navigation: physiology},
      cin          = {AG Wolbers},
      ddc          = {570},
      cid          = {I:(DE-2719)1310002},
      pnm          = {344 - Clinical and Health Care Research (POF3-344)},
      pid          = {G:(DE-HGF)POF3-344},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29551413},
      pmc          = {pmc:PMC5887108},
      doi          = {10.1016/j.cub.2018.02.038},
      url          = {https://pub.dzne.de/record/139887},
}