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| Home > Publications Database > Compromised Grid-Cell-like Representations in Old Age as a Key Mechanism to Explain Age-Related Navigational Deficits. > print |
| 001 | 139887 | ||
| 005 | 20240321220713.0 | ||
| 024 | 7 | _ | |a 10.1016/j.cub.2018.02.038 |2 doi |
| 024 | 7 | _ | |a pmid:29551413 |2 pmid |
| 024 | 7 | _ | |a pmc:PMC5887108 |2 pmc |
| 024 | 7 | _ | |a 0960-9822 |2 ISSN |
| 024 | 7 | _ | |a 1879-0445 |2 ISSN |
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| 041 | _ | _ | |a English |
| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Stangl, Matthias |0 P:(DE-2719)2810620 |b 0 |e First author |u dzne |
| 245 | _ | _ | |a Compromised Grid-Cell-like Representations in Old Age as a Key Mechanism to Explain Age-Related Navigational Deficits. |
| 260 | _ | _ | |a London |c 2018 |b Current Biology Ltd. |
| 264 | _ | 1 | |3 print |2 Crossref |b Elsevier BV |c 2018-04-01 |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1594197278_24853 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a A progressive loss of navigational abilities in old age has been observed in numerous studies, but we have only limited understanding of the neural mechanisms underlying this decline [1]. A central component of the brain's navigation circuit are grid cells in entorhinal cortex [2], largely thought to support intrinsic self-motion-related computations, such as path integration (i.e., keeping track of one's position by integrating self-motion cues) [3-6]. Given that entorhinal cortex is particularly vulnerable to neurodegenerative processes during aging and Alzheimer's disease [7-14], deficits in grid cell function could be a key mechanism to explain age-related navigational decline. To test this hypothesis, we conducted two experiments in healthy young and older adults. First, in an fMRI experiment, we found significantly reduced grid-cell-like representations in entorhinal cortex of older adults. Second, in a behavioral path integration experiment, older adults showed deficits in computations of self-position during path integration based on body-based or visual self-motion cues. Most strikingly, we found that these path integration deficits in older adults could be explained by their individual magnitudes of grid-cell-like representations, as reduced grid-cell-like representations were associated with larger path integration errors. Together, these results show that grid-cell-like representations in entorhinal cortex are compromised in healthy aging. Furthermore, the association between grid-cell-like representations and path integration performance in old age supports the notion that grid cells underlie path integration processes. We therefore conclude that impaired grid cell function may play a key role in age-related decline of specific higher-order cognitive functions, such as spatial navigation. |
| 536 | _ | _ | |a 344 - Clinical and Health Care Research (POF3-344) |0 G:(DE-HGF)POF3-344 |c POF3-344 |f POF III |x 0 |
| 542 | _ | _ | |i 2018-04-01 |2 Crossref |u https://www.elsevier.com/tdm/userlicense/1.0/ |
| 542 | _ | _ | |i 2018-02-20 |2 Crossref |u http://creativecommons.org/licenses/by/4.0/ |
| 588 | _ | _ | |a Dataset connected to CrossRef, PubMed, |
| 650 | _ | 2 | |a Adult |2 MeSH |
| 650 | _ | 2 | |a Aged |2 MeSH |
| 650 | _ | 2 | |a Aging: pathology |2 MeSH |
| 650 | _ | 2 | |a Cognition: physiology |2 MeSH |
| 650 | _ | 2 | |a Entorhinal Cortex: physiology |2 MeSH |
| 650 | _ | 2 | |a Female |2 MeSH |
| 650 | _ | 2 | |a Grid Cells: physiology |2 MeSH |
| 650 | _ | 2 | |a Humans |2 MeSH |
| 650 | _ | 2 | |a Male |2 MeSH |
| 650 | _ | 2 | |a Spatial Memory: physiology |2 MeSH |
| 650 | _ | 2 | |a Spatial Navigation: physiology |2 MeSH |
| 700 | 1 | _ | |a Achtzehn, Johannes |0 P:(DE-2719)2810753 |b 1 |u dzne |
| 700 | 1 | _ | |a Huber, Karin |0 P:(DE-2719)2811995 |b 2 |u dzne |
| 700 | 1 | _ | |a Dietrich, Caroline |0 P:(DE-2719)2811566 |b 3 |u dzne |
| 700 | 1 | _ | |a Tempelmann, Claus |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Wolbers, Thomas |0 P:(DE-2719)2810583 |b 5 |e Last author |u dzne |
| 773 | 1 | 8 | |a 10.1016/j.cub.2018.02.038 |b : Elsevier BV, 2018-04-01 |n 7 |p 1108-1115.e6 |3 journal-article |2 Crossref |t Current Biology |v 28 |y 2018 |x 0960-9822 |
| 773 | _ | _ | |a 10.1016/j.cub.2018.02.038 |g Vol. 28, no. 7, p. 1108 - 1115.e6 |0 PERI:(DE-600)2019214-9 |n 7 |q 28:7<1108 - 1115.e6 |p 1108-1115.e6 |t Current biology |v 28 |y 2018 |x 0960-9822 |
| 856 | 7 | _ | |2 Pubmed Central |u http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5887108 |
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