TY  - JOUR
AU  - Benito, Eva
AU  - Kerimoglu, Cemil
AU  - Ramachandran, Binu
AU  - Pena Centeno, Tonatiuh
AU  - Jain, Gaurav
AU  - Stilling, Roman Manuel
AU  - Islam, Rezaul
AU  - Capece, Vincenzo
AU  - Zhou, Qihui
AU  - Edbauer, Dieter
AU  - Dean, Camin
AU  - Fischer, André
TI  - RNA-Dependent Intergenerational Inheritance of Enhanced Synaptic Plasticity after Environmental Enrichment.
JO  - Cell reports
VL  - 23
IS  - 2
SN  - 2211-1247
CY  - [New York, NY]
PB  - Elsevier
M1  - DZNE-2020-06222
SP  - 546-554
PY  - 2018
AB  - Physical exercise in combination with cognitive training is known to enhance synaptic plasticity, learning, and memory and lower the risk for various complex diseases including Alzheimer's disease. Here, we show that exposure of adult male mice to an environmental enrichment paradigm leads to enhancement of synaptic plasticity and cognition also in the next generation. We show that this effect is mediated through sperm RNA and especially miRs 212/132. In conclusion, our study reports intergenerational inheritance of an acquired cognitive benefit and points to specific miRs as candidates mechanistically involved in this type of transmission.
KW  - Animals
KW  - Behavior, Animal
KW  - Brain: metabolism
KW  - Cognition: physiology
KW  - Excitatory Postsynaptic Potentials
KW  - Hippocampus: physiology
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - MicroRNAs: chemistry
KW  - MicroRNAs: metabolism
KW  - Neuronal Plasticity: physiology
KW  - Physical Conditioning, Animal
KW  - RNA: chemistry
KW  - RNA: isolation & purification
KW  - RNA: metabolism
KW  - Sequence Analysis, RNA
KW  - Social Environment
KW  - Spermatozoa: metabolism
KW  - MIRN132 microRNA, rat (NLM Chemicals)
KW  - MIRN212 microRNA, rat (NLM Chemicals)
KW  - MicroRNAs (NLM Chemicals)
KW  - RNA (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:29642011
C2  - pmc:PMC5912949
DO  - DOI:10.1016/j.celrep.2018.03.059
UR  - https://pub.dzne.de/record/139900
ER  -